Enhanced extrinsic apoptosis of therapy-induced senescent cancer cells using a death receptor 5 (DR5) selective agonist

Tumor Cell Escape from Therapy-Induced Senescence as a Model of Disease Recurrence after Dormancy

(2019) Tareq Saleh et al.   CANCER RESEARCH

Histone Deacetylase Inhibitors Sensitize TRAIL-Induced Apoptosis in Colon Cancer Cells

(2019) Baojie Zhang et al.   Cancers

Regulation of Survival Networks in Senescent Cells: From Mechanisms to Interventions

(2019) Abel Soto-Gamez et al.   JOURNAL OF MOLECULAR BIOLOGY

Developing TRAIL/TRAIL death receptor-based cancer therapies

(2018) Xun Yuan et al.   CANCER AND METASTASIS REVIEWS

Induction and Validation of Cellular Senescence in Primary Human Cells

(2018) Alejandra Hernandez-Segura et al.   Jove-Journal of Visualized Experiments

The Clinical Potential of Senolytic Drugs

(2017) James L. Kirkland et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Decoy TRAIL receptor CD264: a cell surface marker of cellular aging for human bone marrow-derived mesenchymal stem cells

(2017) Sean D. Madsen et al.   Stem Cell Research & Therapy

High-Throughput Functional Genetic and Compound Screens Identify Targets for Senescence Induction in Cancer

(2017) Liqin Wang et al.   Cell Reports

Morphological and Functional Characteristic of Senescent Cancer Cells

(2016) Ewa Sikora et al.   CURRENT DRUG TARGETS

Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

(2016) Reut Yosef et al.   Nature Communications

Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse

(2016) Marco Demaria et al.   Cancer Discovery

Identification of novel therapeutic targets in the secretome of ionizing radiation-induced senescent tumor cells

(2015) HYUN JUNG HWANG et al.   ONCOLOGY REPORTS

Polyploidy Formation in Doxorubicin-Treated Cancer Cells Can Favor Escape from Senescence

(2015) Grazyna Mosieniak et al.   NEOPLASIA

DR4 specific TRAIL variants are more efficacious than wild-type TRAIL in pancreatic cancer

(2014) Rui Yu et al.   CANCER BIOLOGY & THERAPY

Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape

(2013) P. P. Shah et al.   GENES & DEVELOPMENT

Decreased Affinity of Recombinant Human Tumor Necrosis Factor-related Apoptosis-inducing Ligand (rhTRAIL) D269H/E195R to Osteoprotegerin (OPG) Overcomes TRAIL Resistance Mediated by the Bone Microenvironment

(2013) Matthieu C. J. Bosman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resistance to TRAIL in non-transformed cells is due to multiple redundant pathways

(2013) M van Dijk et al.   Cell Death & Disease

Histone Modifications in Senescence-Associated Resistance to Apoptosis by Oxidative Stress

(2013) Yan Y. Sanders et al.   Redox Biology

Granule exocytosis mediates immune surveillance of senescent cells

(2012) A Sagiv et al.   ONCOGENE

Phase I Dose-Escalation Study of Recombinant Human Apo2L/TRAIL, a Dual Proapoptotic Receptor Agonist, in Patients With Advanced Cancer

(2010) Roy S. Herbst et al.   JOURNAL OF CLINICAL ONCOLOGY

Therapy-Induced Senescence in Cancer

(2010) Jonathan A. Ewald et al.   JNCI-Journal of the National Cancer Institute

WNT16B Is a New Marker of Cellular Senescence That Regulates p53 Activity and the Phosphoinositide 3-Kinase/AKT Pathway

(2009) R. Binet et al.   CANCER RESEARCH

High Levels of Id1 Expression Define B1 Type Adult Neural Stem Cells

(2009) Hyung-song Nam et al.   Cell Stem Cell

TRAIL induces apoptosis in triple-negative breast cancer cells with a mesenchymal phenotype

(2008) Monzur Rahman et al.   BREAST CANCER RESEARCH AND TREATMENT

MCF-7 breast carcinoma cells do not express caspase-3

(2008) Reiner U. Jänicke   BREAST CANCER RESEARCH AND TREATMENT

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY