Decreased Affinity of Recombinant Human Tumor Necrosis Factor-related Apoptosis-inducing Ligand (rhTRAIL) D269H/E195R to Osteoprotegerin (OPG) Overcomes TRAIL Resistance Mediated by the Bone Microenvironment

Crystal Structure of Human RANKL Complexed with Its Decoy Receptor Osteoprotegerin

(2012) X. Luan et al.   JOURNAL OF IMMUNOLOGY

Targeting Tumour-Initiating Cells with TRAIL Based Combination Therapy Ensures Complete and Lasting Eradication of Multiple Myeloma Tumours In Vivo

(2012) Srdjan Vitovski et al.   PLoS One

RANKL Employs Distinct Binding Modes to Engage RANK and the Osteoprotegerin Decoy Receptor

(2012) Christopher A. Nelson et al.   STRUCTURE

Perspective: A model disease

(2011) William Matsui   NATURE

Multiple Myeloma

(2011) Antonio Palumbo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rapid and efficient cancer cell killing mediated by high-affinity death receptor homotrimerizing TRAIL variants

(2011) C R Reis et al.   Cell Death & Disease

Proapoptotic DR4 and DR5 signaling in cancer cells: toward clinical translation

(2010) Annie Yang et al.   CURRENT OPINION IN CELL BIOLOGY

Anticancer efficacy of Apo2L/TRAIL is retained in the presence of high and biologically active concentrations of osteoprotegerin in vivo

(2010) Irene Zinonos et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Unraveling the Binding Mechanism of Trivalent Tumor Necrosis Factor Ligands and Their Receptors

(2010) Carlos R. Reis et al.   MOLECULAR & CELLULAR PROTEOMICS

New insights into apoptosis signaling by Apo2L/TRAIL

(2010) F Gonzalvez et al.   ONCOGENE

Generation of new TRAIL mutants DR5-A and DR5-B with improved selectivity to death receptor 5

(2009) Marine E. Gasparian et al.   APOPTOSIS

Enhancement of Antitumor Properties of rhTRAIL by Affinity Increase toward Its Death Receptors†

(2009) Carlos R. Reis et al.   BIOCHEMISTRY

DR4-selective Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Variants Obtained by Structure-based Design

(2008) Vicente Tur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiple Myeloma Cancer Stem Cells

(2008) Carol Ann Huff et al.   JOURNAL OF CLINICAL ONCOLOGY

Cancer Stem Cells in Hematopoietic Malignancies

(2007) Richard J. Jones et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION