Intratumoral DNA-based delivery of checkpoint-inhibiting antibodies and interleukin 12 triggers T cell infiltration and anti-tumor response
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Intratumoral DNA-based delivery of checkpoint-inhibiting antibodies and interleukin 12 triggers T cell infiltration and anti-tumor response
Authors
Keywords
-
Journal
CANCER GENE THERAPY
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-11-09
DOI
10.1038/s41417-021-00403-8
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- EOMES and IL-10 regulate antitumor activity of T regulatory type 1 CD4+ T cells in chronic lymphocytic leukemia
- (2021) Philipp M. Roessner et al. LEUKEMIA
- A novel mouse model for checkpoint inhibitor-induced adverse events
- (2021) Kieran Adam et al. PLoS One
- Improved Potency And Safety Of DNA-encoded Antibody Therapeutics Through Plasmid Backbone And Expression Cassette Engineering
- (2021) Giles Vermeire et al. HUMAN GENE THERAPY
- Intratumoral delivery of tavokinogene telseplasmid yields systemic immune responses in metastatic melanoma patients
- (2020) A. Algazi et al. ANNALS OF ONCOLOGY
- DNA-Based Delivery of Checkpoint Inhibitors in Muscle and Tumor Enables Long-Term Responses with Distinct Exposure
- (2020) Liesl Jacobs et al. MOLECULAR THERAPY
- Phase II Trial of IL-12 Plasmid Transfection and PD-1 Blockade in Immunologically Quiescent Melanoma
- (2020) Alain P. Algazi et al. CLINICAL CANCER RESEARCH
- Oncolytic vaccinia virus delivering tethered IL-12 enhances antitumor effects with improved safety
- (2020) Yan Ge et al. Journal for ImmunoTherapy of Cancer
- Intratumoural immunotherapies for unresectable and metastatic melanoma: current status and future perspectives
- (2020) Mark R. Middleton et al. BRITISH JOURNAL OF CANCER
- DNA-based delivery of anti-DR5 Nanobodies improves exposure and anti-tumor efficacy over protein-based administration
- (2020) Giles Vermeire et al. CANCER GENE THERAPY
- Combination of Ipilimumab and Nivolumab in Cancers: From Clinical Practice to Ongoing Clinical Trials
- (2020) Omid Kooshkaki et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Intratumoral interleukin-12 mRNA therapy promotes TH1 transformation of the tumor microenvironment
- (2020) Susannah L Hewitt et al. CLINICAL CANCER RESEARCH
- Retargeted and multi-cytokine armed herpes virus is a potent cancer endovaccine for local and systemic anti-tumor treatment in combination with anti-PD1
- (2020) Maria De Lucia et al. Molecular Therapy-Oncolytics
- Anchoring of intratumorally administered cytokines to collagen safely potentiates systemic cancer immunotherapy
- (2019) Noor Momin et al. Science Translational Medicine
- Bridging the Clinical Gap for DNA-Based Antibody Therapy Through Translational Studies in Sheep
- (2019) Kevin Hollevoet et al. HUMAN GENE THERAPY
- Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma
- (2019) James Larkin et al. NEW ENGLAND JOURNAL OF MEDICINE
- Intratumoral Delivery of Plasmid IL12 Via Electroporation Leads to Regression of Injected and Noninjected Tumors in Merkel Cell Carcinoma
- (2019) Shailender Bhatia et al. CLINICAL CANCER RESEARCH
- Combination anti–CTLA-4 plus anti–PD-1 checkpoint blockade utilizes cellular mechanisms partially distinct from monotherapies
- (2019) Spencer C. Wei et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Improving therapeutic efficacy of IL-12 intratumoral gene electrotransfer through novel plasmid design and modified parameters
- (2018) C. Burkart et al. GENE THERAPY
- Cancer immunotherapy using checkpoint blockade
- (2018) Antoni Ribas et al. SCIENCE
- Prolonged in vivo expression and anti-tumor response of DNA-based anti-HER2 antibodies
- (2018) Kevin Hollevoet et al. Oncotarget
- Electrotransfer of Different Control Plasmids Elicits Different Antitumor Effectiveness in B16.F10 Melanoma
- (2018) Masa Bosnjak et al. Cancers
- Eomes controls the development of Th17-derived (non-classic) Th1 cells during chronic inflammation
- (2018) Alessio Mazzoni et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Characterization of abscopal effects of intratumoral electroporation-mediated IL-12 gene therapy
- (2018) Anandaroop Mukhopadhyay et al. GENE THERAPY
- Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12
- (2018) Christopher S. Garris et al. IMMUNITY
- IL-12 Gene Electrotransfer Triggers a Change in Immune Response within Mouse Tumors
- (2018) Guilan Shi et al. Cancers
- State of play and clinical prospects of antibody gene transfer
- (2017) Kevin Hollevoet et al. Journal of Translational Medicine
- Matrix-binding checkpoint immunotherapies enhance antitumor efficacy and reduce adverse events
- (2017) Jun Ishihara et al. Science Translational Medicine
- Assessing Immune-Related Adverse Events of Efficacious Combination Immunotherapies in Preclinical Models of Cancer
- (2016) Jing Liu et al. CANCER RESEARCH
- Preclinical Development of Ipilimumab and Nivolumab Combination Immunotherapy: Mouse Tumor Models, In Vitro Functional Studies, and Cynomolgus Macaque Toxicology
- (2016) Mark J. Selby et al. PLoS One
- Virotherapy with a Semliki Forest Virus–Based Vector Encoding IL12 Synergizes with PD-1/PD-L1 Blockade
- (2015) José I. Quetglas et al. Cancer Immunology Research
- Tumoral Expression of IL-33 Inhibits Tumor Growth and Modifies the Tumor Microenvironment through CD8+T and NK Cells
- (2014) Xin Gao et al. JOURNAL OF IMMUNOLOGY
- Anti-CTLA-4 Antibodies of IgG2a Isotype Enhance Antitumor Activity through Reduction of Intratumoral Regulatory T Cells
- (2013) M. J. Selby et al. Cancer Immunology Research
- Intratumoral electroporation of IL-12 cDNA eradicates established melanomas by Trp2180–188-specific CD8+ CTLs in a perforin/granzyme-mediated and IFN-γ-dependent manner: application of Trp2180–188 peptides
- (2012) Jeong-Im Sin et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
- (2010) M. A. Curran et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now