Targeted intervention of eIF4A1 inhibits EMT and metastasis of pancreatic cancer cells via c-MYC/miR-9 signaling

Cancer Statistics, 2021

(2021) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

MYC as a Target for Cancer Treatment

(2021) Michael J Duffy et al.   CANCER TREATMENT REVIEWS

Taking the Myc out of cancer: toward therapeutic strategies to directly inhibit c-Myc

(2021) Sarah K. Madden et al.   Molecular Cancer

EIF4A3: a gatekeeper of autophagy

(2021) Despoina Sakellariou et al.   Autophagy

Early detection of pancreatic cancer

(2020) Stephen P Pereira et al.   Lancet Gastroenterology & Hepatology

Comprehensive analysis of KRAS variants in patients (pts) with pancreatic cancer (PDAC): Clinical/molecular correlations and real-world outcomes across standard therapies.

(2020) Andrew Eugene Hendifar et al.   JOURNAL OF CLINICAL ONCOLOGY

Drugging “undruggable” genes for cancer treatment: Are we making progress?

(2020) Michael J. Duffy et al.   INTERNATIONAL JOURNAL OF CANCER

A First-in-Human Phase I Study to Evaluate the ERK1/2 Inhibitor GDC-0994 in Patients with Advanced Solid Tumors

(2019) Andrea Varga et al.   CLINICAL CANCER RESEARCH

Musashi2 contributes to the maintenance of CD44v6+ liver cancer stem cells via notch1 signaling pathway

(2019) Xiju Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Targeting Protein Translation by Rocaglamide and Didesmethylrocaglamide to Treat MPNST and Other Sarcomas

(2019) Long-Sheng Chang et al.   MOLECULAR CANCER THERAPEUTICS

Rocaglamide enhances NK cell-mediated killing of non-small cell lung cancer cells by inhibiting autophagy

(2018) Chao Yao et al.   Autophagy

Phase I/II trial of pimasertib plus gemcitabine in patients with metastatic pancreatic cancer

(2018) Eric Van Cutsem et al.   INTERNATIONAL JOURNAL OF CANCER

Highly stable and efficient all-inorganic lead-free perovskite solar cells with native-oxide passivation

(2018) Min Chen et al.   Nature Communications

Targeting prohibitins with chemical ligands inhibits KRAS-mediated lung tumours

(2017) H Yurugi et al.   ONCOGENE

Yeast eIF4A enhances recruitment of mRNAs regardless of their structural complexity

(2017) Paul Yourik et al.   eLife

Rocaglates convert DEAD-box protein eIF4A into a sequence-selective translational repressor

(2016) Shintaro Iwasaki et al.   NATURE

Inhibition of the CRAF/prohibitin interaction reverses CRAF-dependent resistance to vemurafenib

(2016) N A Doudican et al.   ONCOGENE

Translational dysregulation in cancer: eIF4A isoforms and sequence determinants of eIF4A dependence

(2015) F. Raza et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

MicroRNAs as regulators and mediators of c-MYC function

(2015) Rene Jackstadt et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Targeting the eIF4F Translation Initiation Complex: A Critical Nexus for Cancer Development

(2015) J. Pelletier et al.   CANCER RESEARCH

Organoid Models of Human and Mouse Ductal Pancreatic Cancer

(2015) Sylvia F. Boj et al.   CELL

Targeting Translation Initiation Bypasses Signaling Crosstalk Mechanisms That Maintain High MYC Levels in Colorectal Cancer

(2015) A. Wiegering et al.   Cancer Discovery

Targeting MYC Translation in Colorectal Cancer

(2015) A. Castell et al.   Cancer Discovery

A Phase Ib Dose-Escalation Study of the Oral Pan-PI3K Inhibitor Buparlisib (BKM120) in Combination with the Oral MEK1/2 Inhibitor Trametinib (GSK1120212) in Patients with Selected Advanced Solid Tumors

(2014) P. L. Bedard et al.   CLINICAL CANCER RESEARCH

Therapeutic Effects of an Anti-Myc Drug on Mouse Pancreatic Cancer

(2014) Dimitris Stellas et al.   JNCI-Journal of the National Cancer Institute

Targeting the prohibitin scaffold-CRAF kinase interaction in RAS-ERK-driven pancreatic ductal adenocarcinoma

(2014) Zhou Luan et al.   Molecular Cancer

Rocaglamide overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells by attenuating the inhibition of caspase-8 through cellular FLICE-like-inhibitory protein downregulation

(2014) ZHOU LUAN et al.   Molecular Medicine Reports

eIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer therapies

(2014) Lise Boussemart et al.   NATURE

Roles for KRAS in Pancreatic Tumor Development and Progression

(2013) Marina Pasca di Magliano et al.   GASTROENTEROLOGY

Direct reprogramming by oncogenic Ras and Myc

(2013) I. Ischenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EMT and Dissemination Precede Pancreatic Tumor Formation

(2012) Andrew D. Rhim et al.   CELL

Endogenous Myc maintains the tumor microenvironment

(2011) N. M. Sodir et al.   GENES & DEVELOPMENT

Myc-modulated miR-9 makes more metastases

(2010) Yeesim Khew-Goodall et al.   NATURE CELL BIOLOGY

miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis

(2010) Li Ma et al.   NATURE CELL BIOLOGY

Canonical Initiation Factor Requirements of the Myc Family of Internal Ribosome Entry Segments

(2009) K. A. Spriggs et al.   MOLECULAR AND CELLULAR BIOLOGY

c-Myc and eIF4F Are Components of a Feedforward Loop that Links Transcription and Translation

(2008) C.-J. Lin et al.   CANCER RESEARCH