Article
Medicine, General & Internal
Gan Yang, Xingqi Cao, Xueqin Li, Jingyun Zhang, Chao Ma, Ning Zhang, Qingyun Lu, Eileen M. Crimmins, Thomas M. Gill, Xi Chen, Zuyun Liu
Summary: Childhood adversity is associated with accelerated aging, and unhealthy lifestyle partially mediates these associations.
Article
Infectious Diseases
Michael Drozd, Mar Pujades-Rodriguez, Patrick J. Lillie, Sam Straw, Ann W. Morgan, Mark T. Kearney, Klaus K. Witte, Richard M. Cubbon
Summary: Various factors including age, gender, smoking, socioeconomic deprivation, and a range of NCDs may increase the risk of infection-related death. Further research is needed to understand why these risk factors are more strongly linked to infection death.
LANCET INFECTIOUS DISEASES
(2021)
Article
Neurosciences
Jende L. Zijlmans, Sander Lamballais, Meike W. Vernooij, M. Arfan Ikram, Annemarie Luik
Summary: This study investigated the associations of sociodemographic, lifestyle, physical, and psychosocial determinants with cognitive reserve, and found that current smoking, diabetes mellitus, and depressive symptoms were associated with a lower cognitive reserve, while more alcohol use was associated with a higher cognitive reserve. Differences between men and women were observed in the factors associated with cognitive reserve.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Cardiac & Cardiovascular Systems
Jae-Seung Yun, Sang-Hyuk Jung, Manu Shivakumar, Brenda Xiao, Amit V. Khera, Hong-Hee Won, Dokyoon Kim
Summary: This study found that genetic risk for T2D is associated with increased risk of CVD. Engaging in a healthy lifestyle and maintaining metabolic health may reduce the risk of CVD, regardless of genetic risk for T2D.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Emmanuel Stamatakis, Katherine B. Owen, Leah Shepherd, Bradley Drayton, Mark Hamer, Adrian E. Bauman
Summary: Using poststratification to match the UKB sample to the target population revealed substantial changes in the protective associations between alcohol use and CVD mortality observed in the unweighted UKB data. Additionally, the difference between unweighted and poststratified estimates may underestimate health risks among individuals with the least healthy lifestyles.
Article
Public, Environmental & Occupational Health
Cristina Ortiz, Teresa Lopez-Cuadrado, Carmen Rodriguez-Blazquez, Roberto Pastor-Barriuso, Inaki Galan
Summary: The study aimed to identify sociodemographic characteristics of the population at risk for a greater clustering of unhealthy behaviors and evaluate the association of such clustering with self-rated health status and disability. The findings showed that the majority of participants had 2 or more risk factors, with men, middle-age individuals, and those with low socioeconomic status being more likely to have multiple risk factors.
PREVENTIVE MEDICINE
(2022)
Article
Endocrinology & Metabolism
Bu B. Yeap, Ross J. Marriott, Leen Antonio, Shalender Bhasin, Adrian S. Dobs, Girish Dwivedi, Leon Flicker, Alvin M. Matsumoto, Claes Ohlsson, Eric S. Orwoll, Suchitra Raj, Christopher M. Reid, Dirk Vanderschueren, Gary A. Wittert, Frederick C. W. Wu, Kevin Murray
Summary: This study found that age and BMI were negatively associated with serum testosterone levels, while SHBG was positively associated with age, indicating the impact of lifestyle and medical factors on male testosterone levels; combinations of different factors could lead to changes in serum testosterone, SHBG, and cFT levels.
CLINICAL ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Jin A. Choi, Su-Nam Lee, Sang-Hyuk Jung, Hong-Hee Won, Jae-Seung Yun
Summary: The study suggests that there is an association between glaucoma and cerebrovascular disease. Glaucoma is found to be an independent risk factor for incident CVD. Furthermore, adopting a healthy lifestyle significantly reduces the risk of developing CVD among individuals with glaucoma.
SCIENTIFIC REPORTS
(2023)
Article
Public, Environmental & Occupational Health
Victor M. Wauye, Frederick K. Ho, Donald M. Lyall
Summary: This study examined predictors of COVID-19 infection among participants in the UK Biobank, finding that factors such as gender, education, socioeconomic status, and psychological factors have significant impacts on the likelihood of infection.
JOURNAL OF PUBLIC HEALTH
(2023)
Article
Medicine, General & Internal
Humberto Yevenes-Briones, Francisco Felix Caballero, Jose Ramon Banegas, Fernando Rodriguez-Artalejo, Esther Lopez-Garcia
Summary: This study analyzed data from the UK Biobank cohort and found that healthy lifestyle behaviors are associated with decreased risk of hearing loss. Individuals with four to five healthy behaviors had a lower risk of hearing loss compared to those with no healthy behaviors. The population attributable risk for not adhering to any of the five low-risk lifestyle behaviors was estimated to be 15.6%.
MAYO CLINIC PROCEEDINGS
(2022)
Article
Multidisciplinary Sciences
Mohammad Mamouei, Yajie Zhu, Milad Nazarzadeh, Abdelaali Hassaine, Gholamreza Salimi-Khorshidi, Yutong Cai, Kazem Rahimi
Summary: Multicollinearity refers to the presence of collinearity between multiple variables and can result in erroneous statistical inference. Principal component analysis is a method used to address this problem, but it may pose challenges in terms of interpretability. Sparse principal component analysis is a promising approach to achieve both multicollinearity resolution and interpretability.
SCIENTIFIC REPORTS
(2022)
Article
Public, Environmental & Occupational Health
Miriam Mutambudzi, Claire Niedwiedz, Ewan Beaton Macdonald, Alastair Leyland, Frances Mair, Jana Anderson, Carlos Celis-Morales, John Cleland, John Forbes, Jason Gill, Claire Hastie, Frederick Ho, Bhautesh Jani, Daniel F. Mackay, Barbara Nicholl, Catherine O'Donnell, Naveed Sattar, Paul Welsh, Jill P. Pell, Srinivasa Vittal Katikireddi, Evangelia Demou
Summary: The study revealed that healthcare workers, social and education workers, and other essential workers were at a higher risk of severe COVID-19 compared to non-essential workers. Within different occupational groups, medical support staff, social care workers, and transport workers had the highest risk. Non-white essential workers had the highest risk of severe COVID-19.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2021)
Article
Respiratory System
Sara De Matteis, Debbie Jarvis, Lucy Darnton, Dario Consonni, Hans Kromhout, Sally Hutchings, Steven S. Sadhra, David Fishwick, Roel Vermeulen, Lesley Rushton, Paul Cullinan
Summary: This large population-based study found an association between occupational exposure to pesticides and risk of COPD. The risk was particularly pronounced among non-smokers and individuals without asthma.
Article
Medicine, General & Internal
Hamish M. E. Foster, Jason M. R. Gill, Frances S. Mair, Carlos A. Celis-Morales, Bhautesh D. Jani, Barbara I. Nicholl, Duncan Lee, Catherine A. O'Donnell
Summary: This study found that both functional and structural components of social connection are independently associated with mortality. It also suggests that the beneficial associations for some types of social connection might not be felt when other types of social connection are absent. Additionally, individuals who live alone with additional structural markers of isolation may represent a high-risk population.
Article
Clinical Neurology
Haoyu Zhao, Qianshu Ma, Min Xie, Yunqi Huang, Yunjia Liu, Huan Song, Hongsheng Gui, Mingli Li, Qiang Wang
Summary: This study aimed to investigate the association between self-rated health (SRH) and subsequent all-cause hospitalizations in patients with bipolar disorder (BD) or major depression (MDD). The results showed that patients with poor SRH had a higher risk of hospitalization, highlighting the importance of proactive SRH screening in this population.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychology, Clinical
Chiara Fabbri, Julian Mutz, Cathryn M. Lewis, Alessandro Serretti
Summary: This study was the first to comprehensively evaluate the predictors of wellbeing in relation to the history of MDD. The identified variables are important to identify individuals at risk and promote wellbeing.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Clinical Neurology
Julian Mutz
Summary: The evidence base for brain stimulation treatments in bipolar disorders is limited but expanding, offering potential as an adjunct or alternative to pharmacological and psychological treatments, with the ability to target all states of bipolar disorders, including cognitive dysfunction during euthymic periods.
Article
Economics
James Shearer, Nicola Metrebian, Tim Weaver, Kimberley Goldsmith, John Strang, Stephen Pilling, Luke Mitcheson, Ed Day, John Dunn, Anthony Glasper, Shabana Akhtar, Jalpa Bajaria, Vikki Charles, Roopal Desai, Farjana Haque, Nicholas Little, Hortencia McKechnie, Franziska Mosler, Julian Mutz, Dilkushi Poovendran, Sarah Byford
Summary: This study conducted a cost-effectiveness analysis of two 12-week contingency management schedules targeting heroin abstinence or attendance at weekly keyworker appointments for opioid agonist treatment. The results showed that neither method was cost-effective over the 24-week follow-up period. However, the method targeting attendance at treatment was cost-effective over the 12-week treatment period. Rating: 7 out of 10.
Article
Public, Environmental & Occupational Health
Hari S. Iyer, Jane B. Vaselkiv, Konrad H. Stopsack, Charlotte Roscoe, Nicole V. DeVille, Yiwen Zhang, Kathryn L. Penney, Steven P. Balk, Michelangelo Fiorentino, Jaime E. Hart, Peter James, Immaculata De Vivo, Lorelei A. Mucci, Francine Laden, Timothy R. Rebbeck
Summary: A study found that neighborhood environment and green space were associated with the development of prostate cancer. The study showed that higher greenness and socioeconomic status were associated with lower odds of postatrophic hyperplasia, while higher socioeconomic status was associated with lower odds of tumor corpora amylacea. These findings suggest that the neighborhood may influence the inflammatory features of prostate tumors.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2023)
Review
Health Care Sciences & Services
Jinlong Zhao, Yat Wa Justina Liu, Stefanos Tyrovolas, Julian Mutz
Summary: This study reviewed the existing definitions of psychological frailty and provided a comprehensive overview of the concept and associated measurements. Psychological frailty is a complex concept whose definition lacks consensus and may include both psychological and physical features. Future research can further refine the concept of psychological frailty.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
Article
Psychology, Clinical
Thole H. Hoppen, Marvin Jehn, Heinz Holling, Julian Mutz, Ahlke Kip, Nexhmedin Morina
Summary: This study provides a comprehensive summary of the effectiveness and acceptability of psychological interventions for adult posttraumatic stress disorder (PTSD). The results indicate that all interventions are effective, but trauma-focused cognitive behavior therapy (TF-CBT) has higher efficacy in the short-term, mid-term, and long-term compared to non-trauma-focused interventions. However, more patients dropped out from TF-CBT than non-trauma-focused interventions. Overall, the results are consistent with most previous quantitative reviews.
JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY
(2023)
Article
Environmental Sciences
Kelly Chen, Jochem O. Klompmaker, Charlotte J. Roscoe, Long H. Nguyen, David A. Drew, Peter James, Francine Laden, Daniela Fecht, Weiyi Wang, John Gulliver, Jonathan Wolf, Claire J. Steves, Tim D. Spector, Andy T. Chan, Jaime E. Hart
Summary: A study found that living in neighborhoods with more green spaces may be associated with a lower risk of COVID-19-like illness, but this association is not observed in all populations.
ENVIRONMENTAL EPIDEMIOLOGY
(2023)
Article
Environmental Sciences
Stephanie T. Grady, Jaime E. Hart, Francine Laden, Charlotte Roscoe, Daniel D. Nguyen, Elizabeth J. Nelson, Matthew Bozigar, Trang VoPham, JoAnn E. Manson, Jennifer Weuve, Sara D. Adar, John P. Forman, Kathryn Rexrode, Jonathan I. Levy, Junenette L. Peters
Summary: This study examined the association between aircraft noise and cardiovascular disease (CVD) risk among two US cohorts. The results showed no adverse associations between aircraft noise and CVD incidence, CVD mortality, or all-cause mortality.
ENVIRONMENTAL EPIDEMIOLOGY
(2023)
Meeting Abstract
Clinical Neurology
Hayley Thorpe, Pierre Fontanillas, Benjamin K. Pham, John J. Meredith, Mariela V. Jennings, Natasia S. Courchesne-Krak, Laura Vilar-Ribo, Sevim B. Bianchi, Julian Mutz, Sarah L. Elson, Jibran Y. Khokhar, Abdel Abdellaoui, Lea K. Davis, Abraham A. Palmer, Sandra Sanchez-Roige
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Meeting Abstract
Neurosciences
Julian Mutz, Cathryn Lewis
BIOLOGICAL PSYCHIATRY
(2023)
Meeting Abstract
Neurosciences
Julian Mutz, Lara Masloch, Clara Martin, Katharina Goeke, Silke Lux, Alexandra Philipsen, Rene Hurlemann, Maximilian Kiebs
BIOLOGICAL PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Amy Shakeshaft, Joanna Martin, Charlotte A. Dennison, Lucy Riglin, Cathryn M. Lewis, Michael C. O'Donovan, Anita Thapar
Summary: This study examined the contribution of parental non-transmitted genetic liability to youth emotional problems. The results showed that genetic liability for anxiety, depression, ADHD, and ASD were associated with youth emotional problems, with stronger associations in adolescence. However, there was limited evidence for non-transmitted genetic effects.
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
Julian Mutz, Cathryn M. Lewis
Summary: This study found that individuals with mental disorders such as anxiety disorder, depression, or bipolar disorder may have shorter telomeres, and the polygenic risk scores (PRSs) for depression are associated with telomere length.
BIOLOGICAL PSYCHIATRY: GLOBAL OPEN SCIENCE
(2023)