Review
Veterinary Sciences
Marta Nowakowska, Muammer uecal, Marios Charalambous, Sofie F. M. Bhatti, Timothy Denison, Sebastian Meller, Gregory A. Worrell, Heidrun Potschka, Holger A. Volk
Summary: Neurostimulation methods have shown promising results in controlling seizures and improving the quality of life for patients with drug-resistant epilepsy. This comprehensive review focuses on the available neurostimulation methods for managing seizures in dogs, with highlights on recent progress in non-invasive modalities.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Clinical Neurology
Marta Cano, Erik Lee, Christopher Polanco, Tracy Barbour, Kristen K. Ellard, Blake Andreou, Sofia Uribe, Michael E. Henry, Stephen Seiner, Narcis Cardoner, Carles Soriano-Mas, Joan A. Camprodon
Summary: In this study, the authors compared the brain volumetric changes in patients with treatment-resistant depression (TRD) after receiving electroconvulsive therapy (ECT) or repetitive transcranial magnetic stimulation (rTMS). The results showed that patients who received ECT exhibited greater volumetric increase in certain brain regions compared to those who received rTMS. However, the changes in brain volume were not associated with clinical improvement.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Lauren Katzell, Emily M. Beydler, Richard Holbert, Laura Rodriguez-Roman, Brent R. Carr
Summary: This article discusses the concomitant use of electroconvulsive therapy (ECT) and vagus nerve stimulation (VNS) in the treatment of super refractory status epilepticus (SRSE). The author presents a case in which ECT was unable to terminate SE and discusses treatment strategies and device limitations.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Clinical Neurology
Charles F. Yates, Kate Riney, Stephen Malone, Ubaid Shah, Liam G. Coulthard, Robert Campbell, Geoff Wallace, Martin Wood
Summary: A study evaluated the outcomes and complications of VNS therapy in a large pediatric cohort in Queensland over a 20-year period, finding that a majority of patients benefited significantly from VNS therapy over extended treatment periods. Most patients retained VNS therapy long-term, with cessation mainly related to minimal benefit, and patient demographics did not influence outcomes.
ACTA NEUROCHIRURGICA
(2022)
Article
Biology
Beniamino Tripodi, Manuel Glauco Carbone, Irene Matarese, Lorenzo Lattanzi, Pierpaolo Medda
Summary: This study describes the case of a 64-year-old woman with recurrent major depressive disorder who showed significant improvement after multiple sessions of electroconvulsive therapy (ECT). These results highlight the importance of early diagnosis and effective treatment for this syndrome to avoid the use of antipsychotic drugs and prevent potentially fatal complications.
Review
Clinical Neurology
Jiangwei Ding, Lei Wang, Wenchao Li, Yangyang Wang, Shucai Jiang, Lifei Xiao, Changliang Zhu, Xiaoyan Hao, Jiali Zhao, Xuerui Kong, Ziqin Wang, Guangyuan Lu, Feng Wang, Tao Sun
Summary: Dravet syndrome is a refractory developmental and epileptic encephalopathy, which can be treated with neuromodulation techniques. Vagus nerve stimulation may be an effective treatment, but carries risks of infection and device failure. The role of deep brain stimulation in DS requires further study.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Meng-Xin Wang, Aihaiti Wumiti, Yao-Wen Zhang, Xue-Sheng Gao, Zi Huang, Meng-Fei Zhang, Zhi-Yong Peng, Yoshitaka Oku, Zhi-Ming Tang
Summary: The aim of this study was to investigate the effect of transcutaneous cervical vagus nerve stimulation (tcVNS) on motor cortex excitability in healthy adults. The results showed that after real stimulation, the amplitude of motor-evoked potential (MEP) significantly increased, while MEP latency and rest motor threshold (rMT) significantly decreased. This suggests that tcVNS can improve motor cortex excitability.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Neurosciences
William T. Regenold, Zhi-De Deng, Sarah H. Lisanby
Summary: The prefrontal cortex is crucial in human unique experiences and mental health disorders. Noninvasive neuromodulation can directly target the PFC, reduce adverse effects, and reveal disease mechanisms by modifying PFC activity.
NEUROPSYCHOPHARMACOLOGY
(2022)
Review
Engineering, Biomedical
D. Ziesel, M. Nowakowska, S. Scheruebel, K. Kornmueller, U. Schaefer, R. Schindl, C. Baumgartner, M. Uecal, T. Rienmueller
Summary: Traumatic brain injury (TBI) is a major cause of cognitive and neurological deficits, as well as psychological disorders. Recent research has focused on electrical stimulation methods as a potential treatment for TBI sequelae, but the underlying mechanisms and optimal timing of these methods are still not fully understood. Animal studies have provided valuable insights into the long- and short-term effects of these stimulation methods and their potential therapeutic benefits.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2023)
Article
Clinical Neurology
Carl Johan Ekman, Katarzyna Popiolek, Robert Boden, Axel Nordenskjold, Johan Lundberg
Summary: This study investigated the effectiveness and tolerability of intermittent Theta-burst stimulation (iTBS) in a clinical setting. The results showed that iTBS was safe and well-tolerated, and the response rate was similar to that reported in clinical trials. Older age and milder illness predicted a better treatment response.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Xing Chen, Tongtong Zhang, Xiaoyan Shan, Qun Yang, Peiyun Zhang, Haijiao Zhu, Fei Jiang, Chao Liu, Yanzhong Li, Weijun Li, Jian Xu, Hongmei Shen
Summary: This study aimed to compare the difference in mood outcomes and cognitive function between high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) and electroconvulsive therapy (ECT) in MDD patients, as well as examine the improvement of HF-rTMS on cognitive impairment caused by ECT. The results showed that HF-rTMS improved psychological anxiety and ameliorated the cognitive impairment evoked by ECT, with the same antidepressant efficacy as ECT.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Medicine, General & Internal
Stefan Evers
Summary: Neurostimulation methods have been studied for over 20 years in the treatment of migraines, with both invasive and non-invasive methods being utilized. Among the non-invasive methods, vagal nerve stimulation, electric peripheral nerve stimulation, transcranial magnetic stimulation, and transcranial direct current stimulation are the most commonly studied and used. However, the efficacy of most procedures is poor due to a lack of consistent positive results from blinded, controlled trials with an adequate number of patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Zakir Mridha, Jan Willem de Gee, Yanchen Shi, Rayan Alkashgari, Justin Williams, Aaron Suminski, Matthew P. Ward, Wenhao Zhang, Matthew James McGinley
Summary: The study demonstrates that pupil dilation is a reliable and noninvasive biosensor for titratable VNS-evoked cortical neuromodulation by acetylcholine in mice.
NATURE COMMUNICATIONS
(2021)
Review
Cell Biology
Giovanni Cirillo, Flor Negrete-Diaz, Daniela Yucuma, Assunta Virtuoso, Sohaib Ali Korai, Ciro De Luca, Eugenijus Kaniusas, Michele Papa, Fivos Panetsos
Summary: This paper provides a comprehensive overview of the pathogenesis and therapeutic approaches for inflammatory bowel diseases. The interaction between the enteric and central nervous systems and the role of the vagus nerve in autoimmune diseases are highlighted. Neuroprosthetic stimulation of the vagus nerve, particularly transcutaneous stimulation of the auricular branch, has been suggested as a potential therapeutic approach for controlling intestinal inflammation.
Article
Neurosciences
Johanna L. Chang, Ashley N. Coggins, Maira Saul, Alexandra Paget-Blanc, Malgorzata Straka, Jason Wright, Timir Datta-Chaudhuri, Stavros Zanos, Bruce T. Volpe
Summary: The study suggests that taVNS during robotic training can lead to positive motor improvements in patients with chronic stroke, particularly in reducing wrist and hand spasticity. By triggering specific visual cues, taVNS helps improve coordinated activation of agonist-antagonist upper arm muscle groups, reducing spasticity and increasing motor control.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Julian Mutz, Allan H. Young, Cathryn M. Lewis
Summary: Individuals with bipolar disorder show significant differences in cardiovascular function and body composition compared to healthy controls, with females exhibiting greater bodily changes. These differences in age-related changes do not uniformly narrow or widen with age, and also vary between males and females.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Julian Mutz, Thole H. Hoppen, Chiara Fabbri, Cathryn M. Lewis
Summary: Anxiety disorders have negative effects on health. This study found differences in physiological measures between middle-aged and older adults with a history of anxiety disorders and healthy controls. These differences decreased with age and were influenced by chronicity and comorbidity with depression.
BRITISH JOURNAL OF PSYCHIATRY
(2022)
Article
Psychology, Clinical
Chiara Fabbri, Julian Mutz, Cathryn M. Lewis, Alessandro Serretti
Summary: This study was the first to comprehensively evaluate the predictors of wellbeing in relation to the history of MDD. The identified variables are important to identify individuals at risk and promote wellbeing.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Environmental Sciences
Claudia Schmutz, Alexandra Burgler, Narain Ashta, Jana Soenksen, Yasmin Bou Karim, Chen Shen, Rachel B. Smith, Rosemary H. Jenkins, Michael O. Mireku, Julian Mutz, Mikael J. A. Maes, Rosi Hirst, Irene Chang, Charlotte Fleming, Aamirah Mussa, Daphna Kesary, Darren Addison, Myron Maslanyj, Mireille B. Toledano, Martin Roosli, Marloes Eeftens
Summary: This study aimed to characterize the personal exposure of adolescents to RF-EMF and investigate the association between exposure and rules implemented at school and home to restrict wireless communication use. The findings suggest that school policies and parental restrictions are not associated with lower RF-EMF exposure in adolescents.
ENVIRONMENTAL RESEARCH
(2022)
Meeting Abstract
Clinical Neurology
Julian Mutz, Cathryn Lewis
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Clinical Neurology
Chiara Fabbri, Julian Mutz, Cathryn M. Lewis, Alessandro Serretti
Summary: This study stratified individuals with lifetime major depressive disorder (MDD) based on their clinical characteristics and found that poor wellbeing in these patients is associated with subthreshold manic/irritable mood fluctuations and personality traits of irritability and neuroticism. The study results may reflect the characteristics of participants in the UK Biobank.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Economics
James Shearer, Nicola Metrebian, Tim Weaver, Kimberley Goldsmith, John Strang, Stephen Pilling, Luke Mitcheson, Ed Day, John Dunn, Anthony Glasper, Shabana Akhtar, Jalpa Bajaria, Vikki Charles, Roopal Desai, Farjana Haque, Nicholas Little, Hortencia McKechnie, Franziska Mosler, Julian Mutz, Dilkushi Poovendran, Sarah Byford
Summary: This study conducted a cost-effectiveness analysis of two 12-week contingency management schedules targeting heroin abstinence or attendance at weekly keyworker appointments for opioid agonist treatment. The results showed that neither method was cost-effective over the 24-week follow-up period. However, the method targeting attendance at treatment was cost-effective over the 12-week treatment period. Rating: 7 out of 10.
Review
Health Care Sciences & Services
Jinlong Zhao, Yat Wa Justina Liu, Stefanos Tyrovolas, Julian Mutz
Summary: This study reviewed the existing definitions of psychological frailty and provided a comprehensive overview of the concept and associated measurements. Psychological frailty is a complex concept whose definition lacks consensus and may include both psychological and physical features. Future research can further refine the concept of psychological frailty.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
Article
Psychology, Clinical
Thole H. Hoppen, Marvin Jehn, Heinz Holling, Julian Mutz, Ahlke Kip, Nexhmedin Morina
Summary: This study provides a comprehensive summary of the effectiveness and acceptability of psychological interventions for adult posttraumatic stress disorder (PTSD). The results indicate that all interventions are effective, but trauma-focused cognitive behavior therapy (TF-CBT) has higher efficacy in the short-term, mid-term, and long-term compared to non-trauma-focused interventions. However, more patients dropped out from TF-CBT than non-trauma-focused interventions. Overall, the results are consistent with most previous quantitative reviews.
JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY
(2023)
Meeting Abstract
Clinical Neurology
Hayley Thorpe, Pierre Fontanillas, Benjamin K. Pham, John J. Meredith, Mariela V. Jennings, Natasia S. Courchesne-Krak, Laura Vilar-Ribo, Sevim B. Bianchi, Julian Mutz, Sarah L. Elson, Jibran Y. Khokhar, Abdel Abdellaoui, Lea K. Davis, Abraham A. Palmer, Sandra Sanchez-Roige
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Meeting Abstract
Neurosciences
Julian Mutz, Cathryn Lewis
BIOLOGICAL PSYCHIATRY
(2023)
Meeting Abstract
Neurosciences
Julian Mutz, Lara Masloch, Clara Martin, Katharina Goeke, Silke Lux, Alexandra Philipsen, Rene Hurlemann, Maximilian Kiebs
BIOLOGICAL PSYCHIATRY
(2023)
Article
Neurosciences
Julian Mutz, Cathryn M. Lewis
Summary: This study found that individuals with mental disorders such as anxiety disorder, depression, or bipolar disorder may have shorter telomeres, and the polygenic risk scores (PRSs) for depression are associated with telomere length.
BIOLOGICAL PSYCHIATRY: GLOBAL OPEN SCIENCE
(2023)
Meeting Abstract
Psychiatry
J. Mutz, T. Hoppen, C. Fabbri, C. Lewis
EUROPEAN PSYCHIATRY
(2022)
