Morphological landscapes from high content imaging reveal cytokine priming strategies that enhance mesenchymal stromal cell immunosuppression

Dose and duration of interferon γ pre-licensing interact with donor characteristics to influence the expression and function of indoleamine-2,3-dioxygenase in mesenchymal stromal cells

(2020) Devlin T. Boyt et al.   Journal of the Royal Society Interface

Hydrogel Culture Surface Stiffness Modulates Mesenchymal Stromal Cell Secretome and Alters Senescence

(2020) Molly E. Ogle et al.   TISSUE ENGINEERING PART A

Therapeutic Potential of Extracellular Vesicles for the Treatment of Nerve Disorders

(2019) Luisa R. Galieva et al.   Frontiers in Neuroscience

Priming approaches to improve the efficacy of mesenchymal stromal cell-based therapies

(2019) Nádia de Cássia Noronha et al.   Stem Cell Research & Therapy

Manufacturing mesenchymal stromal cells for clinical applications: A survey of Good Manufacturing Practices at U.S. academic centers

(2019) Donald G. Phinney et al.   CYTOTHERAPY

Multiplicity of Mesenchymal Stromal Cells: Finding the Right Route to Therapy

(2019) Alison Wilson et al.   Frontiers in Immunology

Characterization of inflammatory factor-induced changes in mesenchymal stem cell exosomes and sequencing analysis of exosomal microRNAs

(2019) Chen Huang et al.   World Journal of Stem Cells

Mesenchymal Stromal Cells: Clinical Challenges and Therapeutic Opportunities

(2018) Jacques Galipeau et al.   Cell Stem Cell

Inducible indoleamine 2,3-dioxygenase 1 and programmed death ligand 1 expression as the potency marker for mesenchymal stromal cells

(2018) Qingdong Guan et al.   CYTOTHERAPY

Modifiers of mesenchymal stem cell quantity and quality

(2018) Athena L. Russell et al.   TRANSFUSION

Functionally-Relevant Morphological Profiling: A Tool to Assess Cellular Heterogeneity

(2018) Ross A. Marklein et al.   TRENDS IN BIOTECHNOLOGY

Potency Analysis of Mesenchymal Stromal Cells Using a Combinatorial Assay Matrix Approach

(2018) Raghavan Chinnadurai et al.   Cell Reports

MSC functionalization for enhanced therapeutic applications

(2018) Dimitrios Kouroupis et al.   TISSUE ENGINEERING PART B-REVIEWS

Functional Profiling of Chondrogenically Induced Multipotent Stromal Cell Aggregates Reveals Transcriptomic and Emergent Morphological Phenotypes Predictive of Differentiation Capacity

(2018) Johnny Lam et al.   Stem Cells Translational Medicine

Morphological profiling using machine learning reveals emergent subpopulations of interferon-γ–stimulated mesenchymal stromal cells that predict immunosuppression

(2018) ROSS A. MARKLEIN et al.   CYTOTHERAPY

Mesenchymal Stromal Cell Secretome: Influencing Therapeutic Potential by Cellular Pre-conditioning

(2018) Joana R. Ferreira et al.   Frontiers in Immunology

Morphological features of IFN-γ–stimulated mesenchymal stromal cells predict overall immunosuppressive capacity

(2017) Matthew W. Klinker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prostaglandin E2 Indicates Therapeutic Efficacy of Mesenchymal Stem Cells in Experimental Traumatic Brain Injury

(2017) Daniel J. Kota et al.   STEM CELLS

Effect of the Microenvironment on Mesenchymal Stem Cell Paracrine Signaling: Opportunities to Engineer the Therapeutic Effect

(2017) Gina D. Kusuma et al.   STEM CELLS AND DEVELOPMENT

A relativity concept in mesenchymal stromal cell manufacturing

(2016) Ivan Martin et al.   CYTOTHERAPY

International Society for Cellular Therapy perspective on immune functional assays for mesenchymal stromal cells as potency release criterion for advanced phase clinical trials

(2016) Jacques Galipeau et al.   CYTOTHERAPY

Cell number and chondrogenesis in human mesenchymal stem cell aggregates is affected by the sulfation level of heparin used as a cell coating

(2016) Jennifer Lei et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Quality cell therapy manufacturing by design

(2016) Yonatan Y Lipsitz et al.   NATURE BIOTECHNOLOGY

High Content Imaging of Early Morphological Signatures Predicts Long Term Mineralization Capacity of Human Mesenchymal Stem Cells upon Osteogenic Induction

(2016) Ross A. Marklein et al.   STEM CELLS

Identification of Predictive Gene Markers for Multipotent Stromal Cell Proliferation

(2016) Ian H. Bellayr et al.   STEM CELLS AND DEVELOPMENT

Mesenchymal stem cells and immunomodulation: current status and future prospects

(2016) F Gao et al.   Cell Death & Disease

Differential and transferable modulatory effects of mesenchymal stromal cell-derived extracellular vesicles on T, B and NK cell functions

(2016) Mariano Di Trapani et al.   Scientific Reports

CXCR3+ Regulatory T Cells Control TH1 Responses in Crescentic GN

(2015) H.-J. Paust et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The translation of cell-based therapies: clinical landscape and manufacturing challenges

(2015) Thomas RJ Heathman et al.   Regenerative Medicine

Chromatin Changes at thePPAR-γ2Promoter During Bone Marrow-Derived Multipotent Stromal Cell Culture Correlate With Loss of Gene Activation Potential

(2015) Patrick J. Lynch et al.   STEM CELLS

Licensing by Inflammatory Cytokines Abolishes Heterogeneity of Immunosuppressive Function of Mesenchymal Stem Cell Population

(2015) Enikő Szabó et al.   STEM CELLS AND DEVELOPMENT

Spatially Organized Differentiation of Mesenchymal Stem Cells within Biphasic Microparticle-Incorporated High Cell Density Osteochondral Tissues

(2015) Loran D. Solorio et al.   Advanced Healthcare Materials

Biomaterial arrays with defined adhesion ligand densities and matrix stiffness identify distinct phenotypes for tumorigenic and non-tumorigenic human mesenchymal cell types

(2014) Tyler D. Hansen et al.   Biomaterials Science

Hypoxia preconditioned human adipose derived mesenchymal stem cells enhance angiogenic potential via secretion of increased VEGF and bFGF

(2013) Linqi Liu et al.   CELL BIOLOGY INTERNATIONAL

Automated microscopy as a quantitative method to measure differences in adipogenic differentiation in preparations of human mesenchymal stromal cells

(2013) Jessica L. Lo Surdo et al.   CYTOTHERAPY

Pre-conditioning mesenchymal stromal cell spheroids for immunomodulatory paracrine factor secretion

(2013) Joshua A. Zimmermann et al.   CYTOTHERAPY

Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels

(2013) Sudhir Khetan et al.   NATURE MATERIALS

PGE2Contributes toIn vitroMSC-Mediated Inhibition of Non-Specific and Antigen-Specific T Cell Proliferation in MS Patients

(2013) M. Zafranskaya et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Global proteomic signature of undifferentiated human bone marrow stromal cells: Evidence for donor-to-donor proteome heterogeneity

(2013) Samuel T. Mindaye et al.   Stem Cell Research

Mesenchymal stem cells from umbilical cord matrix, adipose tissue and bone marrow exhibit different capability to suppress peripheral blood B, natural killer and T cells

(2013) Andreia Ribeiro et al.   Stem Cell Research & Therapy

Activated T-cells and pro-inflammatory cytokines differentially regulate prostaglandin E2 secretion by mesenchymal stem cells

(2012) Beáta Hegyi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mesenchymal stem cells: a double-edged sword in regulating immune responses

(2012) W Li et al.   CELL DEATH AND DIFFERENTIATION

Pre-treatment with IL-1β enhances the efficacy of MSC transplantation in DSS-induced colitis

(2012) Hongye Fan et al.   Cellular & Molecular Immunology

Functional heterogeneity of mesenchymal stem cells: Implications for cell therapy

(2012) Donald G. Phinney   JOURNAL OF CELLULAR BIOCHEMISTRY

Inhibition of activated pericentromeric SINE/Alu repeat transcription in senescent human adult stem cells reinstates self-renewal

(2011) Jianrong Wang et al.   CELL CYCLE

Cryopreserved mesenchymal stromal cells display impaired immunosuppressive properties as a result of heat-shock response and impaired interferon-γ licensing

(2011) Moïra François et al.   CYTOTHERAPY

Human MSC Suppression Correlates With Cytokine Induction of Indoleamine 2,3-Dioxygenase and Bystander M2 Macrophage Differentiation

(2011) Moïra François et al.   MOLECULAR THERAPY

Developing assays to address identity, potency, purity and safety: cell characterization in cell therapy process development

(2011) Jessica Carmen et al.   Regenerative Medicine

Mesenchymal stromal cells use PGE2 to modulate activation and proliferation of lymphocyte subsets: Combined comparison of adipose tissue, Wharton’s Jelly and bone marrow sources

(2010) Mehdi Najar et al.   CELLULAR IMMUNOLOGY

Distinct Roles for CCR4 and CXCR3 in the Recruitment and Positioning of Regulatory T Cells in the Inflamed Human Liver

(2010) Y. H. Oo et al.   JOURNAL OF IMMUNOLOGY

Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate

(2010) Nathaniel Huebsch et al.   NATURE MATERIALS

Pro-Inflammatory Cytokines, IFNγ and TNFα, Influence Immune Properties of Human Bone Marrow and Wharton Jelly Mesenchymal Stem Cells Differentially

(2010) S. Jyothi Prasanna et al.   PLoS One

Genetic Interaction of PGE2 and Wnt Signaling Regulates Developmental Specification of Stem Cells and Regeneration

(2009) Wolfram Goessling et al.   CELL

Mesenchymal Stem Cell-Mediated Immunosuppression Occurs via Concerted Action of Chemokines and Nitric Oxide

(2008) Guangwen Ren et al.   Cell Stem Cell