Advances in developing metabolically engineered microbial platforms to produce fourth-generation biofuels and high-value biochemicals

Bioprospecting of microbial strains for biofuel production: metabolic engineering, applications, and challenges

(2021) Mobolaji Felicia Adegboye et al.   Biotechnology for Biofuels

Photosynthetic production of biodiesel in Synechocystis sp. PCC6803 transformed with insect or plant fatty acid methyltransferase

(2021) Mi-Jin Kang et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Metabolic engineering of Yarrowia lipolytica for improving squalene production

(2021) Wen-Yan Tang et al.   BIORESOURCE TECHNOLOGY

Butanol production from Saccharina japonica hydrolysate by engineered Clostridium tyrobutyricum: the effects of pretreatment method and heat shock protein overexpression

(2021) Hongxin Fu et al.   BIORESOURCE TECHNOLOGY

Developing fourth-generation biofuels secreting microbial cell factories for enhanced productivity and efficient product recovery; a review

(2021) Sana Malik et al.   FUEL

Rationally optimized generation of integrated Escherichia coli with stable and high yield lycopene biosynthesis from heterologous mevalonate (MVA) and lycopene expression pathways

(2021) Muhammad Hammad Hussain et al.   Synthetic and Systems Biotechnology

Multinuclear Yeast Magnusiomyces (Dipodascus, Endomyces) magnusii is a Promising Isobutanol Producer

(2020) Olena O. Kurylenko et al.   Biotechnology Journal

Engineering Pseudomonas putida KT2440 for the production of isobutanol

(2020) Robert Nitschel et al.   ENGINEERING IN LIFE SCIENCES

Metabolic rewiring of synthetic pyruvate dehydrogenase bypasses for acetone production in cyanobacteria

(2020) Hyun Jeong Lee et al.   PLANT BIOTECHNOLOGY JOURNAL

Mitochondrial Compartmentalization Confers Specificity to the 2-Ketoacid Recursive Pathway: Increasing Isopentanol Production in Saccharomyces cerevisiae

(2020) Sarah K. Hammer et al.   ACS Synthetic Biology

Metabolic Engineering of Clostridium cellulovorans to Improve Butanol Production by Consolidated Bioprocessing

(2020) Zhiqiang Wen et al.   ACS Synthetic Biology

Genetic engineering of non-native hosts for 1-butanol production and its challenges: a review

(2020) Said Nawab et al.   Microbial Cell Factories

Quantitative and Qualitative Analyses of Triacylglycerol Production in the Wild-type Cyanobacterium Synechocystis sp. PCC 6803 and the Strain Expressing AtfA from Acinetobacter baylyi ADP1

(2020) Motoki Tanaka et al.   PLANT AND CELL PHYSIOLOGY

Sustainable production of FAEE biodiesel using the oleaginous yeast Yarrowia lipolytica

(2020) Aiqun Yu et al.   MicrobiologyOpen

Metabolic engineering of Escherichia coli for 2,3-butanediol production from cellulosic biomass by using glucose-inducible gene expression system

(2020) Chandran Sathesh-Prabu et al.   BIORESOURCE TECHNOLOGY

Engineering Saccharomyces cerevisiae for production of the valuable monoterpene d-limonene during Chinese Baijiu fermentation

(2020) Zhihui Hu et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Engineering chimeric diterpene synthases and isoprenoid biosynthetic pathways enables high-level production of miltiradiene in yeast

(2020) Tianyuan Hu et al.   METABOLIC ENGINEERING

Overexpression of SFA1 in engineered Saccharomyces cerevisiae to increase xylose utilization and ethanol production from different lignocellulose hydrolysates

(2020) Lang Zhu et al.   BIORESOURCE TECHNOLOGY

Enhancement of fatty acid biosynthesis by exogenous acetyl-CoA carboxylase and pantothenate kinase in Escherichia coli

(2020) Shusaku Satoh et al.   BIOTECHNOLOGY LETTERS

Metabolic engineering strategies toward production of biofuels

(2020) Kyeong Rok Choi et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Synthetic metabolic pathway for the production of 1-alkenes from lignin-derived molecules

(2019) Jin Luo et al.   Microbial Cell Factories

Revisiting metabolic engineering strategies for microbial synthesis of oleochemicals

(2019) Qiang Yan et al.   METABOLIC ENGINEERING

Enhancement of acid re-assimilation and biosolvent production in Clostridium saccharoperbutylacetonicum through metabolic engineering for efficient biofuel production from lignocellulosic biomass

(2019) Pixiang Wang et al.   BIORESOURCE TECHNOLOGY

Improving isobutanol production with the yeast Saccharomyces cerevisiae by successively blocking competing metabolic pathways as well as ethanol and glycerol formation

(2019) Johannes Wess et al.   Biotechnology for Biofuels

Systematic Optimization of Limonene Production in Engineered Escherichia coli

(2019) Jihua Wu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Engineering Yarrowia lipolytica towards food waste bioremediation: Production of fatty acid ethyl esters from vegetable cooking oil

(2019) Tee-Kheang Ng et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Engineering of an oleaginous bacterium for the production of fatty acids and fuels

(2019) Hye Mi Kim et al.   Nature Chemical Biology

Subcellular engineering of lipase dependent pathways directed towards lipid related organelles for highly effectively compartmentalized biosynthesis of triacylglycerol derived products in Yarrowia lipolytica

(2019) Kaixin Yang et al.   METABOLIC ENGINEERING

Enhancement of acetyl-CoA flux for photosynthetic chemical production by pyruvate dehydrogenase complex overexpression in Synechococcus elongatus PCC 7942

(2019) Yasutaka Hirokawa et al.   METABOLIC ENGINEERING

Engineered Rhodobacter capsulatus as a Phototrophic Platform Organism for the Synthesis of Plant Sesquiterpenoids

(2019) Katrin Troost et al.   Frontiers in Microbiology

Metabolic engineering of the marine bacteria Neptunomonas concharum for the production of acetoin and meso-2,3-butanediol from acetate

(2019) Wei Li et al.   BIOCHEMICAL ENGINEERING JOURNAL

Xylose assimilation enhances the production of isobutanol in engineered Saccharomyces cerevisiae

(2019) Stephan Lane et al.   BIOTECHNOLOGY AND BIOENGINEERING

Recent trends in metabolic engineering of microbial chemical factories

(2019) Yi Liu et al.   CURRENT OPINION IN BIOTECHNOLOGY

Enzymatic reactions and pathway engineering for the production of renewable hydrocarbons

(2019) Juthamas Jaroensuk et al.   JOURNAL OF BIOTECHNOLOGY

Methanol-free biosynthesis of fatty acid methyl ester (FAME) in Synechocystis sp. PCC 6803

(2019) Ian Sofian Yunus et al.   METABOLIC ENGINEERING

Tailoring the Saccharomyces cerevisiae endoplasmic reticulum for functional assembly of terpene synthesis pathway

(2019) Jae-Eung Kim et al.   METABOLIC ENGINEERING

A comprehensive state-of-technology review for upgrading bio-oil to renewable or blended hydrocarbon fuels

(2019) Samuel Hansen et al.   RENEWABLE & SUSTAINABLE ENERGY REVIEWS

Electron receptor addition enhances butanol synthesis in ABE fermentation by Clostridium acetobutylicum

(2018) Jian Ding et al.   BIORESOURCE TECHNOLOGY

Production of (2R, 3R)-2,3-butanediol using engineered Pichia pastoris: strain construction, characterization and fermentation

(2018) Zhiliang Yang et al.   Biotechnology for Biofuels

Metabolic engineering of Pichia pastoris for production of isobutanol and isobutyl acetate

(2018) Wiparat Siripong et al.   Biotechnology for Biofuels

Optimization of odd chain fatty acid production by Yarrowia lipolytica

(2018) Young-Kyoung Park et al.   Biotechnology for Biofuels

Phototrophic production of heterologous diterpenoids and a hydroxy-functionalized derivative from Chlamydomonas reinhardtii

(2018) Kyle J. Lauersen et al.   METABOLIC ENGINEERING

Diversion of the long-chain acyl-ACP pool in Synechocystis to fatty alcohols through CRISPRi repression of the essential phosphate acyltransferase PlsX

(2018) Danuta Kaczmarzyk et al.   METABOLIC ENGINEERING

Redirection of lipid flux toward phospholipids in yeast increases fatty acid turnover and secretion

(2018) Raphael Ferreira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In-situ isopentenol production from Bacillus subtilis through genetic and culture condition modulation

(2018) Suresh Chandra Phulara et al.   PROCESS BIOCHEMISTRY

Heterologous Synthesis and Recovery of Advanced Biofuels from Bacterial Cell Factories

(2018) Sana Malik et al.   PROTEIN AND PEPTIDE LETTERS

Recent trends in biobutanol production

(2018) Deepika Kushwaha et al.   REVIEWS IN CHEMICAL ENGINEERING

Engineering 1-Alkene Biosynthesis and Secretion by Dynamic Regulation in Yeast

(2018) Yongjin J. Zhou et al.   ACS Synthetic Biology

Overproduction of Fatty Acid Ethyl Esters by the Oleaginous Yeast Yarrowia lipolytica through Metabolic Engineering and Process Optimization

(2018) Qi Gao et al.   ACS Synthetic Biology

Alka(e)ne synthesis in Cupriavidus necator boosted by the expression of endogenous and heterologous ferredoxin-ferredoxin reductase systems

(2018) Lucie Crépin et al.   BIOTECHNOLOGY AND BIOENGINEERING

Metabolic engineering of Escherichia coli for production of mixed isoprenoid alcohols and their derivatives

(2018) Bakht Zada et al.   Biotechnology for Biofuels

Synthetic metabolic pathways for photobiological conversion of CO2 into hydrocarbon fuel

(2018) Ian Sofian Yunus et al.   METABOLIC ENGINEERING

Modulation of culture medium confers high-specificity production of isopentenol in Bacillus subtilis

(2018) Suresh Chandra Phulara et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Delta-9 fatty acid desaturase overexpression enhanced lipid production and oleic acid content in Rhodosporidium toruloides for preferable yeast lipid production

(2018) Yung-Yu Tsai et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Expression of the heterologous Dunaliella tertiolecta fatty acyl-ACP thioesterase leads to increased lipid production in Chlamydomonas reinhardtii

(2017) Kenneth Wei Min Tan et al.   JOURNAL OF BIOTECHNOLOGY

Enabling the synthesis of medium chain alkanes and 1-alkenes in yeast

(2017) Zhiwei Zhu et al.   METABOLIC ENGINEERING

Metabolic engineering of the pentose phosphate pathway for enhanced limonene production in the cyanobacterium Synechocysti s sp. PCC 6803

(2017) Po-Cheng Lin et al.   Scientific Reports

Alkane biosynthesis by Aspergillus carbonarius ITEM 5010 through heterologous expression of Synechococcus elongatus acyl-ACP/CoA reductase and aldehyde deformylating oxygenase genes

(2017) Malavika Sinha et al.   AMB Express

Whole-cell biocatalytic and de novo production of alkanes from free fatty acids inSaccharomyces cerevisiae

(2016) Jee Loon Foo et al.   BIOTECHNOLOGY AND BIOENGINEERING

Microbial synthesis of propane by engineering valine pathway and aldehyde-deformylating oxygenase

(2016) Lei Zhang et al.   Biotechnology for Biofuels

Metabolic engineering of Zymomonas mobilis for 2,3-butanediol production from lignocellulosic biomass sugars

(2016) Shihui Yang et al.   Biotechnology for Biofuels

Photosynthetic conversion of CO2 to farnesyl diphosphate-derived phytochemicals (amorpha-4,11-diene and squalene) by engineered cyanobacteria

(2016) Sun Young Choi et al.   Biotechnology for Biofuels

Metabolic engineering of oleaginous yeast Yarrowia lipolytica for limonene overproduction

(2016) Xuan Cao et al.   Biotechnology for Biofuels

Engineering the methylerythritol phosphate pathway in cyanobacteria for photosynthetic isoprene production from CO2

(2016) Xiang Gao et al.   Energy & Environmental Science

Strategies of isoprenoids production in engineered bacteria

(2016) Y. Li et al.   JOURNAL OF APPLIED MICROBIOLOGY

Metabolic engineering of Klebsiella pneumoniae based on in silico analysis and its pilot-scale application for 1,3-propanediol and 2,3-butanediol co-production

(2016) Jong Myoung Park et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Heterologous biosynthesis and manipulation of alkanes in Escherichia coli

(2016) Ying-Xiu Cao et al.   METABOLIC ENGINEERING

Fuelling the future: microbial engineering for the production of sustainable biofuels

(2016) James C. Liao et al.   NATURE REVIEWS MICROBIOLOGY

Long-chain alkane production by the yeastSaccharomyces cerevisiae

(2015) Nicolaas A Buijs et al.   BIOTECHNOLOGY AND BIOENGINEERING

Chaotropicity: a key factor in product tolerance of biofuel-producing microorganisms

(2015) Jonathan A Cray et al.   CURRENT OPINION IN BIOTECHNOLOGY

Engineering lipid overproduction in the oleaginous yeast Yarrowia lipolytica

(2015) Kangjian Qiao et al.   METABOLIC ENGINEERING

Fatty acid synthesis in Escherichia coli and its applications towards the production of fatty acid based biofuels

(2014) Helge Janßen et al.   Biotechnology for Biofuels

Toward aldehyde and alkane production by removing aldehyde reductase activity in Escherichia coli

(2014) Gabriel M. Rodriguez et al.   METABOLIC ENGINEERING

Enhanced butanol production in Clostridium acetobutylicum ATCC 824 by double overexpression of 6-phosphofructokinase and pyruvate kinase genes

(2013) Jey-R S. Ventura et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Central metabolic responses to the overproduction of fatty acids inEscherichia colibased on13C-metabolic flux analysis

(2013) Lian He et al.   BIOTECHNOLOGY AND BIOENGINEERING

Borrowing genes from Chlamydomonas reinhardtii for free fatty acid production in engineered cyanobacteria

(2013) Anne M. Ruffing   JOURNAL OF APPLIED PHYCOLOGY

Synthesis of 2,3-butanediol by Synechocystis sp. PCC6803 via heterologous expression of a catabolic pathway from lactic acid- and enterobacteria

(2013) Philipp E. Savakis et al.   METABOLIC ENGINEERING

Metabolic engineering of fatty acyl-ACP reductase-dependent pathway to improve fatty alcohol production in Escherichia coli

(2013) Ran Liu et al.   METABOLIC ENGINEERING

Metabolic engineering of Saccharomyces cerevisiae for production of fatty acid-derived biofuels and chemicals

(2013) Weerawat Runguphan et al.   METABOLIC ENGINEERING

Increased isobutanol production in Saccharomyces cerevisiae by eliminating competing pathways and resolving cofactor imbalance

(2013) Fumio Matsuda et al.   Microbial Cell Factories

Compartmentalization of metabolic pathways in yeast mitochondria improves the production of branched-chain alcohols

(2013) José L Avalos et al.   NATURE BIOTECHNOLOGY

Cyanobacterial conversion of carbon dioxide to 2,3-butanediol

(2013) John W. K. Oliver et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthesis of customized petroleum-replica fuel molecules by targeted modification of free fatty acid pools in Escherichia coli

(2013) T. P. Howard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetic Pathway for Production of Five-Carbon Alcohols from Isopentenyl Diphosphate

(2012) Howard H. Chou et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Engineering the push and pull of lipid biosynthesis in oleaginous yeast Yarrowia lipolytica for biofuel production

(2012) Mitchell Tai et al.   METABOLIC ENGINEERING

Isobutyraldehyde production from Escherichia coli by removing aldehyde reductase activity

(2012) Gabriel M Rodriguez et al.   Microbial Cell Factories

High-flux isobutanol production using engineered Escherichia coli: a bioreactor study with in situ product removal

(2011) Antonino Baez et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Metabolic engineering of monoterpene synthesis in yeast

(2011) Marc J. C. Fischer et al.   BIOTECHNOLOGY AND BIOENGINEERING

Microbial Biosynthesis of Alkanes

(2010) A. Schirmer et al.   SCIENCE

Problems with the microbial production of butanol

(2009) Yan-Ning Zheng et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Overexpression of the gene encoding HMG-CoA reductase in Saccharomyces cerevisiae for production of prenyl alcohols

(2008) Chikara Ohto et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY