The Mpro structure-based modifications of ebselen derivatives for improved antiviral activity against SARS-CoV-2 virus

Discovery of novel inhibitors against main protease (Mpro) of SARS-CoV-2 via virtual screening and biochemical evaluation

(2021) Sheng Guo et al.   BIOORGANIC CHEMISTRY

Cocrystallization of Amantadine Hydrochloride with Resveratrol: The First Drug–Nutraceutical Cocrystal Displaying Synergistic Antiviral Activity

(2021) Ling-Yang Wang et al.   CRYSTAL GROWTH & DESIGN

A novel crystalline molecular salt of sulfamethoxazole and amantadine hybridizing antiviral-antibacterial dual drugs with optimal in vitro/vivo pharmaceutical properties

(2021) Ling-Yang Wang et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Ebsulfur and Ebselen as highly potent scaffolds for the development of potential SARS-CoV-2 antivirals

(2021) Le-Yun Sun et al.   BIOORGANIC CHEMISTRY

3-Alkenyl-2-oxindoles: Synthesis, antiproliferative and antiviral properties against SARS-CoV-2

(2021) Adel S. Girgis et al.   BIOORGANIC CHEMISTRY

Novel inhibitors of the main protease enzyme of SARS-CoV-2 identified via molecular dynamics simulation-guided in vitro assay

(2021) Jennifer Loschwitz et al.   BIOORGANIC CHEMISTRY

Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives

(2021) Kangsa Amporndanai et al.   Nature Communications

α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment

(2020) Linlin Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

A new coronavirus associated with human respiratory disease in China

(2020) Fan Wu et al.   NATURE

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

(2020) Zhenming Jin et al.   NATURE

Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

(2020) Linlin Zhang et al.   SCIENCE

Potential therapeutic use of ebselen for COVID-19 and other respiratory viral infections

(2020) Helmut Sies et al.   FREE RADICAL BIOLOGY AND MEDICINE

A phase 2a randomised, double-blind, placebo-controlled, parallel-group, add-on clinical trial of ebselen (SPI-1005) as a novel treatment for mania or hypomania

(2020) Ann L Sharpley et al.   PSYCHOPHARMACOLOGY

Molecular characterization of ebselen binding activity to SARS-CoV-2 main protease

(2020) Cintia A. Menéndez et al.   Science Advances

Ebselen, a new candidate therapeutic against SARS-CoV-2

(2020) C.V. Haritha et al.   International Journal of Surgery

Development and Therapeutic Potential of Selenazo Compounds

(2019) Ana Carolina Ruberte et al.   JOURNAL OF MEDICINAL CHEMISTRY

Covalent inhibitors design and discovery

(2017) Stephane De Cesco et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Thermal and Photoinduced Copper-Promoted C–Se Bond Formation: Synthesis of 2-Alkyl-1,2-benzisoselenazol-3(2H)-ones and Evaluation against Mycobacterium tuberculosis

(2017) Sandeep Thanna et al.   JOURNAL OF ORGANIC CHEMISTRY

An Overview of Severe Acute Respiratory Syndrome–Coronavirus (SARS-CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy

(2016) Thanigaimalai Pillaiyar et al.   JOURNAL OF MEDICINAL CHEMISTRY

From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design

(2014) Rolf Hilgenfeld   FEBS Journal

A safe lithium mimetic for bipolar disorder

(2013) Nisha Singh et al.   Nature Communications

Synthesis and biological activity of novel organoselenium derivatives targeting multiple kinases and capable of inhibiting cancer progression to metastases

(2011) Krikor Bijian et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Modeling the Mechanism of the Glutathione Peroxidase Mimic Ebselen

(2011) Sonia Antony et al.   INORGANIC CHEMISTRY

Antiatherosclerotic and Renoprotective Effects of Ebselen in the Diabetic Apolipoprotein E/GPx1-Double Knockout Mouse

(2010) P. Chew et al.   DIABETES

Site-Specific Antiatherogenic Effect of the Antioxidant Ebselen in the Diabetic Apolipoprotein E–Deficient Mouse

(2009) Phyllis Chew et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY