Synthesis of a new series of pyrazolo[1,5-a]pyrimidines as CDK2 inhibitors and anti-leukemia

A New CDK2 Inhibitor with 3-Hydrazonoindolin-2-One Scaffold Endowed with Anti-Breast Cancer Activity: Design, Synthesis, Biological Evaluation, and In Silico Insights

(2021) Mohammad M. Al-Sanea et al.   MOLECULES

Eco-friendly sequential one-pot synthesis, molecular docking, and anticancer evaluation of arylidene-hydrazinyl-thiazole derivatives as CDK2 inhibitors

(2021) Abeer M. El-Naggar et al.   BIOORGANIC CHEMISTRY

Synthesis of antimicrobial azoloazines and molecular docking for inhibiting COVID ‐19

(2021) Zeinab A. Muhammad et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The Roles of Cyclin-Dependent Kinases in Cell-Cycle Progression and Therapeutic Strategies in Human Breast Cancer

(2020) Lei Ding et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synthesis of thiazolyl-N-phenylmorpholine derivatives and their biological activities

(2020) Amerah M. Al-Soliemy et al.   Medicinal Chemistry

Synthesis, structure elucidation, DNA binding and molecular docking studies of novel copper(II) complexes of two 1,3,4‐thiadiazolethiosemicarbazone derivatives

(2020) Khadiga M. Takroni et al.   APPLIED ORGANOMETALLIC CHEMISTRY

Synthesis and DNA binding of novel bioactive thiazole derivatives pendent to N-phenylmorpholine moiety

(2020) Thoraya A. Farghaly et al.   BIOORGANIC CHEMISTRY

Discovery of novel indolyl-1,2,4-triazole hybrids as potent vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitors with potential anti-renal cancer activity

(2020) Sami A. Al-Hussain et al.   BIOORGANIC CHEMISTRY

Nano-sized formazan analogues: Synthesis, structure elucidation, antimicrobial activity and docking study for COVID-19

(2020) Huda K. Mahmoud et al.   BIOORGANIC CHEMISTRY

Novel 2-indolinone thiazole hybrids as sunitinib analogues: Design, synthesis, and potent VEGFR-2 inhibition with potential anti-renal cancer activity

(2020) Huda K. Mahmoud et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Fluorinated hydrazonoyl chlorides as precursors for synthesis of antimicrobial azoles

(2020) Sami A. Al‐Hussain et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Efficient Synthesis and Antimicrobial Evaluation of New Azolopyrimidines‐Bearing Pyrazole Moiety

(2019) Abdou O. Abdelhamid et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

A new reactive Ketenaminal: Synthesis, coupling reaction, tautomeric study, docking and antimicrobial evaluation of the products

(2019) Huda K. Mahmoud et al.   Medicinal Chemistry

Study of the mechanism by which dinaciclib induces apoptosis and cell cycle arrest of lymphoma Raji cells through a CDK1 -involved pathway

(2019) Huayan Zhao et al.   Cancer Medicine

Targeting CDK2 in cancer: challenges and opportunities for therapy

(2019) Solomon Tadesse et al.   DRUG DISCOVERY TODAY

Cytotoxicity , docking study of new fluorinated fused pyrimidine scaffold: Thermal and microwave irradiation synthesis

(2019) Alaa M. Abo Alnaja et al.   Medicinal Chemistry

Ubiquitin-dependent degradation of CDK2 drives the therapeutic differentiation of AML by targeting PRDX2

(2018) Meidan Ying et al.   BLOOD

Microwave-assisted and thermal synthesis of nanosized thiazolyl-phenothiazine derivatives and their biological activities

(2018) Manal M. Alsharekh et al.   RESEARCH ON CHEMICAL INTERMEDIATES

Novel Nano-sized bis -indoline Derivatives as Antitumor Agents

(2018) Ismail I. Althagafi et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Synthesis of 4,6-disubstituted pyrazolo[3,4-d]pyrimidine analogues: Cyclin-dependent kinase 2 (CDK2) inhibition, molecular docking and anticancer evaluation

(2018) Srinivasulu Cherukupalli et al.   JOURNAL OF MOLECULAR STRUCTURE

Cyclin-dependent protein serine/threonine kinase inhibitors as anticancer drugs

(2018) Robert Roskoski   PHARMACOLOGICAL RESEARCH

1,3,4-oxadiazole/chalcone hybrids: Design, synthesis, and inhibition of leukemia cell growth and EGFR, Src, IL-6 and STAT3 activities

(2018) Marwa Ali A. Fathi et al.   BIOORGANIC CHEMISTRY

Structure-based discovery of cyclin-dependent protein kinase inhibitors

(2017) Mathew P. Martin et al.   Essays in Biochemistry

An insight on synthetic and medicinal aspects of pyrazolo[1,5- a ]pyrimidine scaffold

(2017) Srinivasulu Cherukupalli et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Emerging cell cycle inhibitors for acute myeloid leukemia

(2017) Abdallah Abou Zahr et al.   EXPERT OPINION ON EMERGING DRUGS

Synthesis and Antimicrobial Activity of Novel Azolopyrimidines and Pyrido-Triazolo-Pyrimidinones Incorporating Pyrazole Moiety

(2017) Ikhlass M. Abbas et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Cyclin-Dependent Kinase (CDK) Inhibitors: Structure–Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines

(2017) Christopher R. Coxon et al.   JOURNAL OF MEDICINAL CHEMISTRY

Microwave-Assisted Synthesis of some Novel Azoles and Azolopyrimidines as Antimicrobial Agents

(2017) Sobhi Gomha et al.   MOLECULES

Inhibitors of cyclin-dependent kinases as cancer therapeutics

(2017) Steven R. Whittaker et al.   PHARMACOLOGY & THERAPEUTICS

Cancer statistics, 2016

(2016) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

A BOILED-Egg To Predict Gastrointestinal Absorption and Brain Penetration of Small Molecules

(2016) Antoine Daina et al.   ChemMedChem

Insights on Structural Characteristics and Ligand Binding Mechanisms of CDK2

(2015) Yan Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The history and future of targeting cyclin-dependent kinases in cancer therapy

(2015) Uzma Asghar et al.   NATURE REVIEWS DRUG DISCOVERY

Exploration of Type II Binding Mode: A Privileged Approach for Kinase Inhibitor Focused Drug Discovery?

(2014) Zheng Zhao et al.   ACS Chemical Biology

Cyclin-Dependent Kinase-2 as a Target for Cancer Therapy: Progress in the Development of CDK2 Inhibitors as Anti-Cancer Agents

(2014) Tahir Chohan et al.   CURRENT MEDICINAL CHEMISTRY

Cyclin-Dependent Kinase Inhibitor Dinaciclib Interacts with the Acetyl-Lysine Recognition Site of Bromodomains

(2013) Mathew P. Martin et al.   ACS Chemical Biology

Synthesis of pyrazolo[1,5-a]pyrimidine linked aminobenzothiazole conjugates as potential anticancer agents

(2013) Ahmed Kamal et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

An in silico exploration of the interaction mechanism of pyrazolo[1,5-a]pyrimidine type CDK2 inhibitors

(2013) Yan Li et al.   Molecular BioSystems

Regioselectivity in the multicomponent reaction of 5-aminopyrazoles, cyclic 1,3-diketones and dimethylformamide dimethylacetal under controlled microwave heating

(2012) Kamal Usef Sadek et al.   Beilstein Journal of Organic Chemistry

4-Thiazolidinones in Heterocyclic Synthesis: Synthesis of Novel Enaminones, Azolopyrimidines and 2-Arylimino-5-arylidene-4-thiazolidinones

(2012) Haider Behbehani et al.   MOLECULES

A Novel Pyrazolo[1,5-a]pyrimidine Is a Potent Inhibitor of Cyclin-Dependent Protein Kinases 1, 2, and 9, Which Demonstrates Antitumor Effects in Human Tumor Xenografts Following Oral Administration

(2010) Dean A. Heathcote et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dinaciclib (SCH 727965), a Novel and Potent Cyclin-Dependent Kinase Inhibitor

(2010) David Parry et al.   MOLECULAR CANCER THERAPEUTICS

Synthesis, anti-HCV, antioxidant, and peroxynitrite inhibitory activity of fused benzosuberone derivatives

(2009) Thoraya A. Farghaly et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

p21 Inhibits Cdk1 in the Absence of Cdk2 to Maintain the G1/S Phase DNA Damage Checkpoint

(2007) Ande Satyanarayana et al.   MOLECULAR BIOLOGY OF THE CELL