Novel benzothiazole-based dual VEGFR-2/EGFR inhibitors targeting breast and liver cancers: Synthesis, cytotoxic activity, QSAR and molecular docking studies

Synthesis, Antitumor and Antibacterial Studies of New Shortened Analogues of (KLAKLAK)2-NH2 and Their Conjugates Containing Unnatural Amino Acids

(2021) Sirine Jaber et al.   MOLECULES

Discovery of 4-alkoxy-2-aryl-6,7-dimethoxyquinolines as a new class of topoisomerase I inhibitors endowed with potent in vitro anticancer activity

(2021) Mostafa M. Elbadawi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel benzothiazole hybrids targeting EGFR: Design, synthesis, biological evaluation and molecular docking studies

(2021) Eman A. Abd El-Meguid et al.   JOURNAL OF MOLECULAR STRUCTURE

Design, synthesis, and molecular docking of novel 2‐arylbenzothiazole multiangiokinase inhibitors targeting breast cancer

(2020) Heba T. Abdel‐Mohsen et al.   ARCHIV DER PHARMAZIE

Amino acids in cancer

(2020) Elizabeth L. Lieu et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Dual EGFR/VEGF pathway inhibition: a promising strategy for patients with EGFR-mutant NSCLC

(2020) Xiuning Le et al.   Journal of Thoracic Oncology

Novel oxindole/benzofuran hybrids as potential dual CDK2/GSK-3β inhibitors targeting breast cancer: design, synthesis, biological evaluation, and in silico studies

(2020) Wagdy M. Eldehna et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Novel benzimidazole derivatives as anti-cervical cancer agents of potential multi-targeting kinase inhibitory activity

(2020) Eman A. Abd El-Meguid et al.   Arabian Journal of Chemistry

Design, synthesis and in silico insights of new 7,8-disubstituted-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione derivatives with potent anticancer and multi-kinase inhibitory activities

(2020) Abdalla R. Mohamed et al.   BIOORGANIC CHEMISTRY

Efficient and easy synthesis of new Benzo[h]chromene and Benzo[h]quinoline derivatives as a new class of cytotoxic agents

(2019) Mogedda E. Haiba et al.   JOURNAL OF MOLECULAR STRUCTURE

Synthesis of New 1,3,4-Oxadiazole-benzimidazole Derivatives as Potential Antioxidants and Breast Cancer Inhibitors with Apoptosis Inducing Activity

(2019) E. A. Abd El-Meguid et al.   RUSSIAN JOURNAL OF GENERAL CHEMISTRY

Synthesis and Cytotoxic Activity of New 1,3,4-Thiadiazole Thioglycosides and 1,2,3-Triazolyl-1,3,4-Thiadiazole N-glycosides

(2019) Alminderej et al.   MOLECULES

Design, Synthesis and Biological Evaluation of Diosgenin-Amino Acid Derivatives with Dual Functions of Neuroprotection and Angiogenesis

(2019) Desheng Cai et al.   MOLECULES

Benzothiazole derivatives as anticancer agents

(2019) Ali Irfan et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Amino acid conjugated antimicrobial drugs: Synthesis, lipophilicity- activity relationship, antibacterial and urease inhibition activity

(2018) Atta Ullah et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, anticancer activity and molecular modeling studies of 1,2,4-triazole derivatives as EGFR inhibitors

(2018) Hany A.M. El-Sherief et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Discovery of new quinazoline derivatives as irreversible dual EGFR/HER2 inhibitors and their anticancer activities – Part 1

(2018) Debasis Das et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Increasing the binding affinity of VEGFR-2 inhibitors by extending their hydrophobic interaction with the active site: Design, synthesis and biological evaluation of 1-substituted-4-(4-methoxybenzyl)phthalazine derivatives

(2016) Wagdy M. Eldehna et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Classification of small molecule protein kinase inhibitors based upon the structures of their drug-enzyme complexes

(2016) Robert Roskoski   PHARMACOLOGICAL RESEARCH

VEGF-A/VEGFR2 signaling network in endothelial cells relevant to angiogenesis

(2016) Chandran S. Abhinand et al.   Journal of Cell Communication and Signaling

Multi-Kinase Inhibitors

(2015) Laura Garuti et al.   CURRENT MEDICINAL CHEMISTRY

Liver cancer: Approaching a personalized care

(2015) Jordi Bruix et al.   JOURNAL OF HEPATOLOGY

Expression and prognostic significance of VEGFR-2 in breast cancer

(2015) Ji-Dong Yan et al.   PATHOLOGY RESEARCH AND PRACTICE

Synthesis of some novel 4-benzothiazol-2-yl-benzoyl-1H-pyrazoles, and evaluation as antiangiogenic agents

(2015) Eman Ali Abd El-Meguid et al.   RESEARCH ON CHEMICAL INTERMEDIATES

FDA-approved small-molecule kinase inhibitors

(2015) Peng Wu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Combination of Amino Acid/Dipeptide with Nitric Oxide Donating Oleanolic Acid Derivatives as PepT1 Targeting Antitumor Prodrugs

(2014) Lei Fang et al.   JOURNAL OF MEDICINAL CHEMISTRY

New series of benzothiazole and pyrimido[2,1-b]benzothiazole derivatives: synthesis, antitumor activity, EGFR tyrosine kinase inhibitory activity and molecular modeling studies

(2014) Moustafa T. Gabr et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis, Anti-Breast Cancer Activity, and Molecular Modeling of Some Benzothiazole and Benzoxazole Derivatives

(2013) Mohamed A. Abdelgawad et al.   ARCHIV DER PHARMAZIE

Descriptor Selection Methods in Quantitative Structure–Activity Relationship Studies: A Review Study

(2013) Mohsen Shahlaei   CHEMICAL REVIEWS

Synthesis and SAR Studies of Urea and Thiourea Derivatives of Gly/Pro Conjugated to Piperazine Analogue as Potential AGE Inhibitors

(2013) Doddahindaiah Vardhan et al.   PROTEIN AND PEPTIDE LETTERS

Antimycobacterial Activity of Some Synthesized Fluorinated Benzothiazolo Imidazole Compounds

(2012) B. S. Sathe et al.   E-Journal of Chemistry

Medicinal significance of benzothiazole scaffold: an insight view

(2012) Prabodh Chander Sharma et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Molecular conformations, interactions, and properties associated with drug efficiency and clinical performance among VEGFR TK inhibitors

(2012) M. McTigue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthesis of uriedo and thiouriedo derivatives of peptide conjugated heterocycles – A new class of promising antimicrobials

(2011) R. Suhas et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Gastroprotective Effect and Cytotoxicity of Labdeneamides with Amino Acids

(2010) Guillermo Schmeda-Hirschmann et al.   PLANTA MEDICA

An efficient copper(II)-catalyzed synthesis of benzothiazoles through intramolecular coupling-cyclization of N-(2-chlorophenyl)benzothioamides

(2010) E.A. Jaseer et al.   TETRAHEDRON LETTERS

Combined Inhibition of Vascular Endothelial Growth Factor and Epidermal Growth Factor Signaling in Non–Small-Cell Lung Cancer Therapy

(2009) Suchita Pakkala et al.   Clinical Lung Cancer

In vitro solubility, stability and permeability of novel quercetin–amino acid conjugates

(2008) Mi Kyoung Kim et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Recent Advances in the Development of Multi-Kinase Inhibitors

(2008) Martin Krug et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY