Synthesis and characterization of chiral 6-azaspiro[2.5]octanes as potent and selective antagonists of the M4 muscarinic acetylcholine receptor

Discovery of VU6028418: A Highly Selective and Orally Bioavailable M4 Muscarinic Acetylcholine Receptor Antagonist

(2021) Matthew Spock et al.   ACS Medicinal Chemistry Letters

Discovery of BMS-986144, a Third-Generation, Pan-Genotype NS3/4A Protease Inhibitor for the Treatment of Hepatitis C Virus Infection

(2020) Li-Qiang Sun et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Selective M4 Muscarinic Acetylcholine Receptor Agonists with Novel Carbamate Isosteres

(2019) Qingyi Yang et al.   ACS Medicinal Chemistry Letters

Roles of the M4 acetylcholine receptor in the basal ganglia and the treatment of movement disorders

(2019) Mark S. Moehle et al.   MOVEMENT DISORDERS

Crystal structure of the M5muscarinic acetylcholine receptor

(2019) Ziva Vuckovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists

(2018) Hongtao Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of 4-Azaindole Inhibitors of TGFβRI as Immuno-oncology Agents

(2018) Yong Zhang et al.   ACS Medicinal Chemistry Letters

Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions

(2016) Paula Ruiz-Castillo et al.   CHEMICAL REVIEWS

Characterization of PCS1055, a novel muscarinic M4 receptor antagonist

(2016) Carrie H. Croy et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors

(2016) Mark Zak et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antipsychotic-like Effects of M 4 Positive Allosteric Modulators Are Mediated by CB 2 Receptor-Dependent Inhibition of Dopamine Release

(2016) Daniel J. Foster et al.   NEURON

Discovery of Spirofused Piperazine and Diazepane Amides as Selective Histamine-3 Antagonists with in Vivo Efficacy in a Mouse Model of Cognition

(2014) Dean G. Brown et al.   JOURNAL OF MEDICINAL CHEMISTRY

Muscarinic acetylcholine receptors: novel opportunities for drug development

(2014) Andrew C. Kruse et al.   NATURE REVIEWS DRUG DISCOVERY

Evaluation of a 3-amino-8-azabicyclo[3.2.1]octane replacement in the CCR5 antagonist maraviroc

(2010) Rémy C. Lemoine et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Muscarinic acetylcholine receptors as CNS drug targets

(2007) Christopher J. Langmead et al.   PHARMACOLOGY & THERAPEUTICS