Roles of the M4 acetylcholine receptor in the basal ganglia and the treatment of movement disorders

Pedunculopontine Nucleus Cholinergic Deficiency in Cervical Dystonia

(2018) Karin Mente et al.   MOVEMENT DISORDERS

M1-positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition

(2018) Sean P. Moran et al.   NEUROPSYCHOPHARMACOLOGY

Heterozygous Gnal Mice Are a Novel Animal Model with Which to Study Dystonia Pathophysiology

(2017) Assunta Pelosi et al.   JOURNAL OF NEUROSCIENCE

Parkinsonism without dopamine neuron degeneration in aged l -dopa-responsive dystonia knockin mice

(2017) Samuel J. Rose et al.   MOVEMENT DISORDERS

Cholinergic Projections to the Substantia Nigra Pars Reticulata Inhibit Dopamine Modulation of Basal Ganglia through the M 4 Muscarinic Receptor

(2017) Mark S. Moehle et al.   NEURON

Allosteric Modulation of GPCRs: New Insights and Potential Utility for Treatment of Schizophrenia and Other CNS Disorders

(2017) Daniel J. Foster et al.   NEURON

Cell-Type-Specific Control of Brainstem Locomotor Circuits by Basal Ganglia

(2016) Thomas K. Roseberry et al.   CELL

Involvement of Striatal Cholinergic Interneurons and M1 and M4 Muscarinic Receptors in Motor Symptoms of Parkinson's Disease

(2016) S. Ztaou et al.   JOURNAL OF NEUROSCIENCE

Cholinergic Mesopontine Signals Govern Locomotion and Reward through Dissociable Midbrain Pathways

(2016) Cheng Xiao et al.   NEURON

Antipsychotic-like Effects of M 4 Positive Allosteric Modulators Are Mediated by CB 2 Receptor-Dependent Inhibition of Dopamine Release

(2016) Daniel J. Foster et al.   NEURON

Role for the M1 Muscarinic Acetylcholine Receptor in Top-Down Cognitive Processing Using a Touchscreen Visual Discrimination Task in Mice

(2015) R. W. Gould et al.   ACS Chemical Neuroscience

Diagnosis and Treatment of Dystonia

(2015) H.A. Jinnah et al.   NEUROLOGIC CLINICS

M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced Dyskinesia

(2015) Weixing Shen et al.   NEURON

Potentiation of M1 Muscarinic Receptor Reverses Plasticity Deficits and Negative and Cognitive Symptoms in a Schizophrenia Mouse Model

(2015) A Ghoshal et al.   NEUROPSYCHOPHARMACOLOGY

Allosteric activation of M4muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 mice

(2015) Tristano Pancani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Forebrain deletion of the dystonia protein torsinA causes dystonic-like movements and loss of striatal cholinergic neurons

(2015) Samuel S Pappas et al.   eLife

Behavioral and Electrophysiological Characterization of Dyt1 Heterozygous Knockout Mice

(2015) Fumiaki Yokoi et al.   PLoS One

Dopamine Receptor and Gα(olf) Expression in DYT1 Dystonia Mouse Models during Postnatal Development

(2015) Lin Zhang et al.   PLoS One

M4 mAChR-Mediated Modulation of Glutamatergic Transmission at Corticostriatal Synapses

(2014) Tristano Pancani et al.   ACS Chemical Neuroscience

Selective Activation of M4 Muscarinic Acetylcholine Receptors Reverses MK-801-Induced Behavioral Impairments and Enhances Associative Learning in Rodents

(2014) Michael Bubser et al.   ACS Chemical Neuroscience

Pharmacological Treatment of Parkinson Disease

(2014) Barbara S. Connolly et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A Major External Source of Cholinergic Innervation of the Striatum and Nucleus Accumbens Originates in the Brainstem

(2014) D. Dautan et al.   JOURNAL OF NEUROSCIENCE

M5 Receptor Activation Produces Opposing Physiological Outcomes in Dopamine Neurons Depending on the Receptor's Location

(2014) D. J. Foster et al.   JOURNAL OF NEUROSCIENCE

Anticholinergic drugs rescue synaptic plasticity in DYT1 dystonia: Role of M1muscarinic receptors

(2014) Marta Maltese et al.   MOVEMENT DISORDERS

Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders

(2014) P. Jeffrey Conn et al.   NATURE REVIEWS DRUG DISCOVERY

Muscarinic acetylcholine receptors: novel opportunities for drug development

(2014) Andrew C. Kruse et al.   NATURE REVIEWS DRUG DISCOVERY

Antipsychotic Drug-Like Effects of the Selective M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator VU0152100

(2014) Nellie E Byun et al.   NEUROPSYCHOPHARMACOLOGY

Pedunculopontine Nucleus Stimulation: Where are We Now and What Needs to be Done to Move the Field Forward?

(2014) Hokuto Morita et al.   Frontiers in Neurology

Genetics in Dystonia: An Update

(2013) Tania Fuchs et al.   Current Neurology and Neuroscience Reports

Role of Gα(olf) in familial and sporadic adult-onset primary dystonia

(2013) Satya R. Vemula et al.   HUMAN MOLECULAR GENETICS

Medical treatment of dystonia

(2013) Joseph Jankovic   MOVEMENT DISORDERS

Gait speed in Parkinson disease correlates with cholinergic degeneration

(2013) N. I. Bohnen et al.   NEUROLOGY

New genetic insights highlight ‘old’ ideas on motor dysfunction in dystonia

(2013) Rose E. Goodchild et al.   TRENDS IN NEUROSCIENCES

Mutations in GNAL cause primary torsion dystonia

(2012) Tania Fuchs et al.   NATURE GENETICS

Effects of acetylcholine in the striatum: Recent insights and therapeutic implications

(2012) E. E. Benarroch   NEUROLOGY

Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior

(2012) Marina R. Picciotto et al.   NEURON

An allosteric enhancer of M4 muscarinic acetylcholine receptor function inhibits behavioral and neurochemical effects of cocaine

(2012) Ditte Dencker et al.   PSYCHOPHARMACOLOGY

The M1/M4 preferring agonist xanomeline reverses amphetamine-, MK801- and scopolamine-induced abnormalities of latent inhibition: putative efficacy against positive, negative and cognitive symptoms in schizophrenia

(2011) Segev Barak et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Involvement of a Subpopulation of Neuronal M4 Muscarinic Acetylcholine Receptors in the Antipsychotic-like Effects of the M1/M4 Preferring Muscarinic Receptor Agonist Xanomeline

(2011) D. Dencker et al.   JOURNAL OF NEUROSCIENCE

Muscarinic and Nicotinic Acetylcholine Receptor Agonists and Allosteric Modulators for the Treatment of Schizophrenia

(2011) Carrie K Jones et al.   NEUROPSYCHOPHARMACOLOGY

Increased cocaine self-administration in M4 muscarinic acetylcholine receptor knockout mice

(2011) Lene S. Schmidt et al.   PSYCHOPHARMACOLOGY

Centrality of Striatal Cholinergic Transmission in Basal Ganglia Function

(2011) Paola Bonsi et al.   Frontiers in Neuroanatomy

Acetylcholine-dopamine balance hypothesis in the striatum: An update

(2010) Toshihiko Aosaki et al.   Geriatrics & Gerontology International

Cholinergic mesencephalic neurons are involved in gait and postural disorders in Parkinson disease

(2010) Carine Karachi et al.   JOURNAL OF CLINICAL INVESTIGATION

A Subpopulation of Neuronal M4 Muscarinic Acetylcholine Receptors Plays a Critical Role in Modulating Dopamine-Dependent Behaviors

(2010) J. Jeon et al.   JOURNAL OF NEUROSCIENCE

History of falls in Parkinson disease is associated with reduced cholinergic activity

(2009) N. I. Bohnen et al.   NEUROLOGY

Molecular Mechanisms of Action and In Vivo Validation of an M4 Muscarinic Acetylcholine Receptor Allosteric Modulator with Potential Antipsychotic Properties

(2009) Katie Leach et al.   NEUROPSYCHOPHARMACOLOGY

Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders

(2009) P. Jeffrey Conn et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

(2008) P. Jeffrey Conn et al.   NATURE REVIEWS DRUG DISCOVERY