Further exploration of the structure-activity relationship of dual soluble epoxide hydrolase/fatty acid amide hydrolase inhibitors

Inhibition of the Soluble Epoxide Hydrolase as an Analgesic Strategy: A Review of Preclinical Evidence

(2021) Yuxin Wang et al.   Journal of Pain Research

Multi-Target Approaches in Metabolic Syndrome

(2021) Felix F. Lillich et al.   Frontiers in Pharmacology

Design, microwave‐assisted synthesis, biological evaluation and molecular modeling studies of 4‐phenylthiazoles as potent fatty acid amide hydrolase inhibitors

(2020) Stephanie R. Wilt et al.   Chemical Biology & Drug Design

Heteroarylureas with Fused Bicyclic Diamine Cores as Inhibitors of Fatty Acid Amide Hydrolase

(2020) John M. Keith et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Development of multitarget inhibitors for the treatment of pain: Design, synthesis, biological evaluation and molecular modeling studies

(2020) Stephanie Wilt et al.   BIOORGANIC CHEMISTRY

Role of epoxy-fatty acids and epoxide hydrolases in the pathology of neuro-inflammation

(2019) Sean D. Kodani et al.   BIOCHIMIE

Trends in clinical success rates and therapeutic focus

(2019) Helen Dowden et al.   NATURE REVIEWS DRUG DISCOVERY

Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase

(2018) Sean D. Kodani et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Current Status of Drug Discovery and Development as Originated in US Academia: The Influence of Industrial and Academic Collaboration on Drug Discovery and Development

(2018) Tohru Takebe et al.   CTS-Clinical and Translational Science

Comparative Evaluation of Covalent Docking Tools

(2018) Andrea Scarpino et al.   Journal of Chemical Information and Modeling

Assessing protein–ligand interaction scoring functions with the CASF-2013 benchmark

(2018) Yan Li et al.   Nature Protocols

ProTox-II: a webserver for the prediction of toxicity of chemicals

(2018) Priyanka Banerjee et al.   NUCLEIC ACIDS RESEARCH

Novel piperidine-derived amide sEH inhibitors as mediators of lipid metabolism with improved stability

(2018) Stevan Pecic et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Hybrid receptor structure/ligand-based docking and activity prediction in ICM: development and evaluation in D3R Grand Challenge 3

(2018) Polo C.-H. Lam et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Polypharmacology by Design: A Medicinal Chemist’s Perspective on Multitargeting Compounds

(2018) Ewgenij Proschak et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ligand-biased ensemble receptor docking (LigBEnD): a hybrid ligand/receptor structure-based approach

(2017) Polo C.-H. Lam et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Soluble epoxide hydrolase as a therapeutic target for pain, inflammatory and neurodegenerative diseases

(2017) Karen M. Wagner et al.   PHARMACOLOGY & THERAPEUTICS

Anti-inflammatory ω-3 endocannabinoid epoxides

(2017) Daniel R. McDougle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammatory responses and inflammation-associated diseases in organs

(2017) Linlin Chen et al.   Oncotarget

BDDCS, the Rule of 5 and drugability

(2016) Leslie Z. Benet et al.   ADVANCED DRUG DELIVERY REVIEWS

Triptolide Attenuates Inflammatory Response in Membranous Glomerulo-Nephritis Rat via Downregulation of NF-κB Signaling Pathway

(2016) Ying Zhou et al.   KIDNEY & BLOOD PRESSURE RESEARCH

The Molecular Basis for Dual Fatty Acid Amide Hydrolase (FAAH)/Cyclooxygenase (COX) Inhibition

(2015) Giulia Palermo et al.   ChemMedChem

A multimodal disease modifying approach to treat neuropathic pain – inhibition of soluble epoxide hydrolase (sEH)

(2015) Sivaram Pillarisetti et al.   DRUG DISCOVERY TODAY

NSAIDs: Learning new tricks from old drugs

(2015) Federico Díaz-González et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Comparing sixteen scoring functions for predicting biological activities of ligands for protein targets

(2015) Weijun Xu et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Peripheral FAAH and soluble epoxide hydrolase inhibitors are synergistically antinociceptive

(2015) Oscar Sasso et al.   PHARMACOLOGICAL RESEARCH

Tuning hERG Out: Antitarget QSAR Models for Drug Development

(2014) Rodolpho Braga et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Soluble epoxide hydrolase: Gene structure, expression and deletion

(2013) Todd R. Harris et al.   GENE

Impact of Soluble Epoxide Hydrolase and Epoxyeicosanoids on Human Health

(2012) Christophe Morisseau et al.   Annual Review of Pharmacology and Toxicology

Synthesis and structure–activity relationship of piperidine-derived non-urea soluble epoxide hydrolase inhibitors

(2012) Stevan Pecic et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Endocannabinoid System and Pain

(2012) Josee Guindon et al.   CNS & Neurological Disorders-Drug Targets

An efficient randomised, placebo-controlled clinical trial with the irreversible fatty acid amide hydrolase-1 inhibitor PF-04457845, which modulates endocannabinoids but fails to induce effective analgesia in patients with pain due to osteoarthritis of the knee

(2012) John P. Huggins et al.   PAIN

The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH)

(2011) Katerina Otrubova et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis and evaluation of non-urea inhibitors of soluble epoxide hydrolase

(2011) Stevan Pecic et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Crystal Structure of Fatty Acid Amide Hydrolase Bound to the Carbamate Inhibitor URB597: Discovery of a Deacylating Water Molecule and Insight into Enzyme Inactivation

(2010) Mauro Mileni et al.   JOURNAL OF MOLECULAR BIOLOGY

Interactions between the immune and nervous systems in pain

(2010) Ke Ren et al.   NATURE MEDICINE

Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism

(2010) Jason R Clapper et al.   NATURE NEUROSCIENCE

Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain

(2009) Kay Ahn et al.   CHEMISTRY & BIOLOGY

Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders

(2009) Kay Ahn et al.   Expert Opinion on Drug Discovery

A Cytochrome P450-Derived Epoxygenated Metabolite of Anandamide Is a Potent Cannabinoid Receptor 2-Selective Agonist

(2009) N. T. Snider et al.   MOLECULAR PHARMACOLOGY

Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases

(2009) John D. Imig et al.   NATURE REVIEWS DRUG DISCOVERY

Epoxyeicosanoid signaling in CNS function and disease

(2009) Jeffrey J. Iliff et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Synthesis and Evaluation of Benzothiazole-Based Analogues as Novel, Potent, and Selective Fatty Acid Amide Hydrolase Inhibitors

(2008) Xueqing Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

In Silico Prediction of the Chemical Block of Human Ether-a-Go-Go-Related Gene (hERG) K+ Current

(2008) Atsushi Inanobe et al.   Journal of Physiological Sciences