Tumor-activatable biomineralized nanotherapeutics for integrative glucose starvation and sensitized metformin therapy

Endogenous H2S-Activated Orthogonal Second Near-Infrared Emissive Nanoprobe for In Situ Ratiometric Fluorescence Imaging of Metformin-Induced Liver Injury

(2021) Zhiming Deng et al.   ACS Nano

Boosting anti-PD-1 therapy with metformin-loaded macrophage-derived microparticles

(2021) Zhaohan Wei et al.   Nature Communications

NIR‐Actuated Remote Activation of Ferroptosis in Target Tumor Cells through a Photothermally Responsive Iron‐Chelated Biopolymer Nanoplatform

(2021) Chencheng Xue et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cell-programmed nutrient partitioning in the tumour microenvironment

(2021) Bradley I. Reinfeld et al.   NATURE

Glucose Starvation Blocks Translation at Multiple Levels

(2020) Chen-Song Zhang et al.   Cell Metabolism

Mitochondrial Complex I Inhibition by Metformin: Drug–Exercise Interactions

(2020) S. Martín-Rodríguez et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Developing New Cancer Nanomedicines by Repurposing Old Drugs

(2020) Bowen Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

GPD1 enhances the anti-cancer effects of metformin by synergistically increasing total cellular glycerol-3-phosphate

(2020) Jianjiang Xie et al.   CANCER RESEARCH

Selective PP2A Enhancement through Biased Heterotrimer Stabilization

(2020) Daniel Leonard et al.   CELL

Smart magnetofluorogenic photosensitizer nanoassemblies enabling redox‐driven disassembly for photodynamic therapy

(2020) Ruibing An et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hypoxia in tumor microenvironment regulates exosome biogenesis: Molecular mechanisms and translational opportunities

(2020) Ashish Kumar et al.   CANCER LETTERS

Assessment of cognitive and neural recovery in survivors of pediatric brain tumors in a pilot clinical trial using metformin

(2020) Ramy Ayoub et al.   NATURE MEDICINE

Type 2 Diabetes Mellitus Drugs for Alzheimer’s Disease: Current Evidence and Therapeutic Opportunities

(2020) Lei Meng et al.   TRENDS IN MOLECULAR MEDICINE

Coordinate β-adrenergic inhibition of mitochondrial activity and angiogenesis arrest tumor growth

(2020) Cristina Nuevo-Tapioles et al.   Nature Communications

Nanoenabled Intracellular Calcium Bursting for Safe and Efficient Reversal of Drug Resistance in Tumor Cells

(2020) Junjie Liu et al.   NANO LETTERS

Select Stabilization of a Tumor-Suppressive PP2A Heterotrimer

(2020) Vidhi M. Shah et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Modified carbon nitride nanozyme as bifunctional glucose oxidase-peroxidase for metal-free bioinspired cascade photocatalysis

(2019) Peng Zhang et al.   Nature Communications

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

(2019) Mohamed Elgendy et al.   CANCER CELL

Molecular Comprehension of Mcl-1: From Gene Structure to Cancer Therapy

(2019) Viacheslav V. Senichkin et al.   TRENDS IN CELL BIOLOGY

Nanozymes: From New Concepts, Mechanisms, and Standards to Applications

(2019) Minmin Liang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Nanoclustered Cascaded Enzymes for Targeted Tumor Starvation and Deoxygenation-Activated Chemotherapy without Systemic Toxicity

(2019) Yinchu Ma et al.   ACS Nano

Potential-Responsive Surfaces for Manipulation of Cell Adhesion, Release, and Differentiation

(2019) Libing Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

AZD4573 is a highly selective CDK9 inhibitor that suppresses Mcl-1 and induces apoptosis in hematological cancer cells.

(2019) Justin Cidado et al.   CLINICAL CANCER RESEARCH

Biodegradable Manganese-Doped Calcium Phosphate Nanotheranostics for Traceable Cascade Reaction-Enhanced Anti-Tumor Therapy

(2019) Lian-Hua Fu et al.   ACS Nano

Periodic Nucleation of Calcium Phosphate in a Stirred Biocatalytic Reaction

(2019) Bíborka Bohner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

GDF15 mediates the effects of metformin on body weight and energy balance

(2019) Anthony P. Coll et al.   NATURE

Glucose & oxygen exhausting liposomes for combined cancer starvation and hypoxia-activated therapy

(2018) Rui Zhang et al.   BIOMATERIALS

Glycogen synthase kinase 3 inhibition lowers PD-1 expression, promotes long-term survival and memory generation in antigen-specific CAR-T cells

(2018) Sadhak Sengupta et al.   CANCER LETTERS

Metformin-Induced Reduction of CD39 and CD73 Blocks Myeloid-Derived Suppressor Cell Activity in Patients with Ovarian Cancer

(2018) Lifeng Li et al.   CANCER RESEARCH

Catalytic chemistry of glucose oxidase in cancer diagnosis and treatment

(2018) Lian-Hua Fu et al.   CHEMICAL SOCIETY REVIEWS

A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo

(2018) Suping Li et al.   NATURE BIOTECHNOLOGY

Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo

(2018) Anila K. Madiraju et al.   NATURE MEDICINE

Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges

(2018) Dai Fukumura et al.   Nature Reviews Clinical Oncology

Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin

(2018) Dannielle DeWaal et al.   Nature Communications

A Non-apoptotic Function of MCL-1 in Promoting Pluripotency and Modulating Mitochondrial Dynamics in Stem Cells

(2018) Megan L. Rasmussen et al.   Stem Cell Reports

Calcium Bisphosphonate Nanoparticles with Chelator-Free Radiolabeling to Deplete Tumor-Associated Macrophages for Enhanced Cancer Radioisotope Therapy

(2018) Longlong Tian et al.   ACS Nano

Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells

(2018) Don Benjamin et al.   Cell Reports

Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug

(2017) Hao Wu et al.   NATURE MEDICINE

Glucose-Responsive Sequential Generation of Hydrogen Peroxide and Nitric Oxide for Synergistic Cancer Starving-Like/Gas Therapy

(2016) Wenpei Fan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Glycogen synthase kinase 3β (GSK3β) in tumorigenesis and cancer chemotherapy

(2008) Jia Luo   CANCER LETTERS