Genetic Evidence Supporting a Causal Role of Depression in Alzheimer’s Disease

Genetic control of the human brain proteome

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Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer’s disease pathogenesis

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Brain proteome-wide association study implicates novel proteins in depression pathogenesis

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Shared proteomic effects of cerebral atherosclerosis and Alzheimer’s disease on the human brain

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Shared genetic etiology underlying Alzheimer’s disease and major depressive disorder

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Depression—an underrecognized target for prevention of dementia in Alzheimer’s disease

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Tutorial: a guide to performing polygenic risk score analyses

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Sleep, major depressive disorder, and Alzheimer disease

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Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

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Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions

(2019) David M. Howard et al.   NATURE NEUROSCIENCE

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

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PRSice-2: Polygenic Risk Score software for biobank-scale data

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Religious Orders Study and Rush Memory and Aging Project

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The GWAS Risk Genes for Depression May Be Actively Involved in Alzheimer’s Disease

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Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases

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Causal associations between risk factors and common diseases inferred from GWAS summary data

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GWAS on family history of Alzheimer’s disease

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A multi-omic atlas of the human frontal cortex for aging and Alzheimer’s disease research

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Neurobiological substrates underlying the effect of genomic risk for depression on the conversion of amnestic mild cognitive impairment

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The Drug Repurposing Hub: a next-generation drug library and information resource

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Assessing the presence of shared genetic architecture between Alzheimer’s disease and major depressive disorder using genome-wide association data

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Next-generation genotype imputation service and methods

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Depressive symptoms increase the risk of progression to dementia in subjects with mild cognitive impairment: systematic review and meta-analysis

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LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

Arizona Study of Aging and Neurodegenerative Disorders and Brain and Body Donation Program

(2015) Thomas G. Beach et al.   NEUROPATHOLOGY

Proteogenomic characterization of human colon and rectal cancer

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Late-life depression and risk of vascular dementia and Alzheimer's disease: systematic review and meta-analysis of community-based cohort studies

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Overview and Findings from the Rush Memory and Aging Project

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A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data

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An integrated map of genetic variation from 1,092 human genomes

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Systematic Discovery of Rab GTPases with Synaptic Functions in Drosophila

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Upregulation of select rab GTPases in cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease

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A genome-wide scan for common variants affecting the rate of age-related cognitive decline

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GCTA: A Tool for Genome-wide Complex Trait Analysis

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Robust relationship inference in genome-wide association studies

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METAL: fast and efficient meta-analysis of genomewide association scans

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Depressive symptoms and risk of dementia: The Framingham Heart Study

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Prevalence of depression among older Americans: the Aging, Demographics and Memory Study

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