Engineering of an EpCAM-targeting cyclic peptide to improve the EpCAM-mediated cellular internalization and tumor accumulation of a peptide-fused antibody

Engineering of Humanized Antibodies Against Human Interleukin 5 Receptor Alpha Subunit That Cause Potent Antibody-Dependent Cell-Mediated Cytotoxicity

(2021) Jung-Eun Kim et al.   Frontiers in Immunology

Affinity Maturation of a T-Cell Receptor-Like Antibody Specific for a Cytomegalovirus pp65-Derived Peptide Presented by HLA-A*02:01

(2021) Se-Young Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intracellular KRAS-specific antibody enhances the anti-tumor efficacy of gemcitabine in pancreatic cancer by inducing endosomal escape

(2021) Ji Eun Lee et al.   CANCER LETTERS

Direct targeting of oncogenic RAS mutants with a tumor-specific cytosol-penetrating antibody inhibits RAS mutant–driven tumor growth

(2020) Seung-Min Shin et al.   Science Advances

Targeting Strategies for Tissue-Specific Drug Delivery

(2020) Zongmin Zhao et al.   CELL

A neuropilin-1 antagonist exerts anti-tumor immunity by inhibiting the suppressive function of intratumoral regulatory T cells

(2019) Keunok Jung et al.   Cancer Immunology Research

Dual-targeting of EGFR and Neuropilin-1 attenuates resistance to EGFR-targeted antibody therapy in KRAS-mutant non-small cell lung cancer

(2019) Ye-Jin Kim et al.   CANCER LETTERS

Engineering of a tumor cell–specific, cytosol-penetrating antibody with high endosomal escape efficacy

(2018) Ji-sun Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

High Affinity Promotes Internalization of Engineered Antibodies Targeting FGFR1

(2018) Łukasz Opaliński et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Peptide-based targeted therapeutics: Focus on cancer treatment

(2018) Fatemeh Araste et al.   JOURNAL OF CONTROLLED RELEASE

Engineering of a GLP-1 analogue peptide/anti-PCSK9 antibody fusion for type 2 diabetes treatment

(2018) Matthieu Chodorge et al.   Scientific Reports

Immunoglobulin Fc-Fused Peptide without C-Terminal Arg or Lys Residue Augments Neuropilin-1-Dependent Tumor Vascular Permeability

(2017) Du-San Baek et al.   MOLECULAR PHARMACEUTICS

Biophysical properties of the clinical-stage antibody landscape

(2017) Tushar Jain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibody targeting intracellular oncogenic Ras mutants exerts anti-tumour effects after systemic administration

(2017) Seung-Min Shin et al.   Nature Communications

Endosomal acidic pH-induced conformational changes of a cytosol-penetrating antibody mediate endosomal escape

(2016) Ji-Sun Kim et al.   JOURNAL OF CONTROLLED RELEASE

A novel screening method to assess developability of antibody-like molecules

(2015) Neeraj Kohli et al.   mAbs

A general strategy for generating intact, full-length IgG antibodies that penetrate into the cytosol of living cells

(2014) Dong-Ki Choi et al.   mAbs

Epithelial cell adhesion molecule-targeted drug delivery for cancer therapy

(2013) Manuel Simon et al.   Expert Opinion on Drug Delivery

Monoclonal antibody therapeutics with up to five specificities: Functional enhancement through fusion of target-specific peptides

(2013) David LaFleur et al.   mAbs

Pyroglutamate andO-Linked Glycan Determine Functional Production of Anti-IL17A and Anti-IL22 Peptide-Antibody Bispecific Genetic Fusions

(2012) Xiaotian Zhong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Influence of Affinity and Antigen Internalization on the Uptake and Penetration of Anti-HER2 Antibodies in Solid Tumors

(2011) S. I. Rudnick et al.   CANCER RESEARCH

A Novel Fusion Toxin Derived from an EpCAM-Specific Designed Ankyrin Repeat Protein Has Potent Antitumor Activity

(2010) P. Martin-Killias et al.   CLINICAL CANCER RESEARCH

The functional capacity of the natural amino acids for molecular recognition

(2010) Sara Birtalan et al.   Molecular BioSystems

EpCAM-targeted delivery of nanocomplexed siRNA to tumor cells with designed ankyrin repeat proteins

(2009) J. Winkler et al.   MOLECULAR CANCER THERAPEUTICS