LAMP3 inhibits autophagy and contributes to cell death by lysosomal membrane permeabilization

Lysosome-associated membrane protein 3 misexpression in salivary glands induces a Sjögren’s syndrome-like phenotype in mice

(2021) Hiroyuki Nakamura et al.   ANNALS OF THE RHEUMATIC DISEASES

The gene for the lysosomal protein LAMP3 is a direct target of the transcription factor ATF4

(2020) Thomas D. Burton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Restoration of lysosomal function after damage is accompanied by recycling of lysosomal membrane proteins

(2020) Ida Eriksson et al.   Cell Death & Disease

Role of Viral Infections in the Pathogenesis of Sjögren’s Syndrome: Different Characteristics of Epstein-Barr Virus and HTLV-1

(2020) Hideki Nakamura et al.   Journal of Clinical Medicine

Autophagy as a modulator of cell death machinery

(2020) Masayuki Noguchi et al.   Cell Death & Disease

Endoplasmic reticulum stress and protein degradation in chronic liver disease

(2020) Si-Wei Xia et al.   PHARMACOLOGICAL RESEARCH

LAMP3 induces apoptosis and autoantigen release in Sjögren’s syndrome patients

(2020) Tsutomu Tanaka et al.   Scientific Reports

Autophagy as a Therapeutic Target to Enhance Aged Muscle Regeneration

(2019) David Lee et al.   Cells

Autophagy and immunological aberrations in systemic lupus erythematosus

(2019) Yuan-yuan Qi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Discrepancy of Serological and Molecular Patterns of Circulating Epstein-Barr Virus Reactivation in Primary Sjögren's Syndrome

(2019) Armen Sanosyan et al.   Frontiers in Immunology

Endothelial cell pyroptosis plays an important role in Kawasaki disease via HMGB1/RAGE/cathespin B signaling pathway and NLRP3 inflammasome activation

(2019) Chang Jia et al.   Cell Death & Disease

Remission of Nephrotic Syndrome After Therapy for Chronic Hepatitis C Virus Infection in a Patient With Systemic Lupus Erythematosus

(2018) Hiroyuki Nakamura et al.   ANNALS OF INTERNAL MEDICINE

Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype

(2018) Georgia Minakaki et al.   Autophagy

Lysosomal membrane permeabilization as a cell death mechanism in cancer cells

(2018) Ana Serrano-Puebla et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Targeted Magnetic Intra-Lysosomal Hyperthermia produces lysosomal reactive oxygen species and causes Caspase-1 dependent cell death

(2018) Pascal Clerc et al.   JOURNAL OF CONTROLLED RELEASE

Follistatin-like protein 5 inhibits hepatocellular carcinoma progression by inducing caspase-dependent apoptosis and regulating Bcl-2 family proteins

(2018) Chunlei Li et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The Therapeutic and Pathogenic Role of Autophagy in Autoimmune Diseases

(2018) Heng Yin et al.   Frontiers in Immunology

Autophagic Mechanism in Anti-Cancer Immunity: Its Pros and Cons for Cancer Therapy

(2017) Ying-Ying Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Crosstalk of autophagy and apoptosis: Involvement of the dual role of autophagy under ER stress

(2017) Shuling Song et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Anti-ENA antibody profiles in patients with hepatitis C virus infection

(2017) Christine M. Litwin et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

Nonradioactive quantification of autophagic protein degradation with L-azidohomoalanine labeling

(2017) Jigang Wang et al.   Nature Protocols

Autophagic flux control in neurodegeneration: Progress and precision targeting—Where do we stand?

(2017) Dumisile Lumkwana et al.   PROGRESS IN NEUROBIOLOGY

Autophagy blockade and lysosomal membrane permeabilization contribute to lead-induced nephrotoxicity in primary rat proximal tubular cells

(2017) Xiang-Bin Song et al.   Cell Death & Disease

Primary Sjögren’s Syndrome Adversely Affects the Female Sexual Function Assessed by the Female Sexual Function Index: A Case-Control Study

(2017) Çağlar Yıldız   Archives of Rheumatology

Elevation of autophagy markers in Sjögren syndrome dry eye

(2017) Yong-Soo Byun et al.   Scientific Reports

Protective mechanisms of CA074-me (other than cathepsin-B inhibition) against programmed necrosis induced by global cerebral ischemia/reperfusion injury in rats

(2016) Yang Xu et al.   BRAIN RESEARCH BULLETIN

What is the evidence for Sjögrenʼs syndrome being triggered by viral infection? Subplot

(2016) Hideki Nakamura et al.   CURRENT OPINION IN RHEUMATOLOGY

LAMP-3 (Lysosome-Associated Membrane Protein 3) Promotes the Intracellular Proliferation of Salmonella typhimurium

(2016) Eun-Ju Lee et al.   MOLECULES AND CELLS

Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells

(2016) Jennifer Martinez et al.   NATURE

Autophagic flux is highly active in early mitosis and differentially regulated throughout the cell cycle

(2016) Zhiyuan Li et al.   Oncotarget

2016 American College of Rheumatology/European League Against Rheumatism Classification Criteria for Primary Sjögren's Syndrome: A Consensus and Data-Driven Methodology Involving Three International Patient Cohorts

(2016) Caroline H. Shiboski et al.   Arthritis & Rheumatology

Sensitive detection of lysosomal membrane permeabilization by lysosomal galectin puncta assay

(2015) Sonja Aits et al.   Autophagy

Loss of lysosome-associated membrane protein 3 (LAMP3) enhances cellular vulnerability against proteasomal inhibition

(2015) Jorge Antolio Dominguez-Bautista et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Characterization of type I interferon pathway during hepatic differentiation of human pluripotent stem cells and hepatitis C virus infection

(2015) Joseph Ignatius Irudayam et al.   Stem Cell Research

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

(2014) Daniel J. Klionsky et al.   Autophagy

V-ATPase and osmotic imbalances activate endolysosomal LC3 lipidation

(2014) Oliver Florey et al.   Autophagy

Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome

(2014) Mi-Hyang Cho et al.   Autophagy

LAMP3 is involved in tamoxifen resistance in breast cancer cells through the modulation of autophagy

(2014) Anika Nagelkerke et al.   ENDOCRINE-RELATED CANCER

Hepatitis C virus infection and the risk of Sjögren or sicca syndrome: a meta-analysis

(2014) Yan Wang et al.   MICROBIOLOGY AND IMMUNOLOGY

Lysosomal membrane permeabilization in cell death: Concepts and challenges

(2014) Urška Repnik et al.   MITOCHONDRION

DNA Microarray Analysis of Labial Salivary Glands in IgG4-Related Disease: Comparison With Sjögren's Syndrome

(2014) Hiroto Tsuboi et al.   Arthritis & Rheumatology

Association of Bone Morphogenetic Protein 6 With Exocrine Gland Dysfunction in Patients With Sjögren's Syndrome and in Mice

(2013) Hongen Yin et al.   ARTHRITIS AND RHEUMATISM

Mitochondrial Reactive Oxygen Species Induces NLRP3-Dependent Lysosomal Damage and Inflammasome Activation

(2013) M. E. Heid et al.   JOURNAL OF IMMUNOLOGY

Advances in understanding the pathogenesis of primary Sjögren's syndrome

(2013) Gaëtane Nocturne et al.   Nature Reviews Rheumatology

The PERK/ATF4/LAMP3-arm of the unfolded protein response affects radioresistance by interfering with the DNA damage response

(2013) Anika Nagelkerke et al.   RADIOTHERAPY AND ONCOLOGY

Impairment of lysosomal integrity by B10, a glycosylated derivative of betulinic acid, leads to lysosomal cell death and converts autophagy into a detrimental process

(2012) P Gonzalez et al.   CELL DEATH AND DIFFERENTIATION

Cathepsin D Primes Caspase-8 Activation by Multiple Intra-chain Proteolysis

(2012) Sébastien Conus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Detection of HTLV-1 in the Labial Salivary Glands of Patients with Sjogren's Syndrome: A Distinct Clinical Subgroup?

(2012) S.-J. LEE et al.   JOURNAL OF RHEUMATOLOGY

Chitinases in the salivary glands and circulation of patients with Sjögren's syndrome: Macrophage harbingers of disease severity

(2011) Teresa Greenwell-Wild et al.   ARTHRITIS AND RHEUMATISM

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

(2011) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Stat3 controls lysosomal-mediated cell death in vivo

(2011) Peter A. Kreuzaler et al.   NATURE CELL BIOLOGY

HSP70 and lysosomal storage disorders: novel therapeutic opportunities

(2010) Nikolaj H.T. Petersen et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Rapid generation of maturationally synchronized human dendritic cells: contribution to the clinical efficacy of extracorporeal photochemotherapy

(2010) C. Berger et al.   BLOOD

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Lysosomal membrane permeabilization and cathepsin release is a Bax/Bak-dependent, amplifying event of apoptosis in fibroblasts and monocytes

(2010) C Oberle et al.   CELL DEATH AND DIFFERENTIATION

Hsp70 stabilizes lysosomes and reverts Niemann–Pick disease-associated lysosomal pathology

(2010) Thomas Kirkegaard et al.   NATURE

Apoptosis in animal models of virus-induced disease

(2009) Penny Clarke et al.   NATURE REVIEWS MICROBIOLOGY

Hypoxic activation of the unfolded protein response (UPR) induces expression of the metastasis-associated gene LAMP3

(2009) Hilda Mujcic et al.   RADIOTHERAPY AND ONCOLOGY

Transduction of rat pancreatic islets with pseudotyped adeno-associated virus vectors

(2009) Anthony T Craig et al.   Virology Journal

Cathepsin D: A cellular roadmap

(2008) Nousheen Zaidi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cathepsins: Key modulators of cell death and inflammatory responses

(2008) Sébastien Conus et al.   BIOCHEMICAL PHARMACOLOGY

Sensitization to the Lysosomal Cell Death Pathway by Oncogene-Induced Down-regulation of Lysosome-Associated Membrane Proteins 1 and 2

(2008) N. Fehrenbacher et al.   CANCER RESEARCH

Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells

(2008) Tereza Vogiatzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysosomal membrane permeabilization in cell death

(2008) P Boya et al.   ONCOGENE