Therapeutic mTOR blockade in systemic autoimmunity: Implications for antiviral immunity and extension of lifespan

SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition

(2021) Peter J. Mullen et al.   Nature Communications

Transcriptional landscape of SARS-CoV-2 infection dismantles pathogenic pathways activated by the virus, proposes unique sex-specific differences and predicts tailored therapeutic strategies

(2020) Paolo Fagone et al.   AUTOIMMUNITY REVIEWS

Increased mTOR activation in idiopathic multicentric Castleman disease

(2020) Daniel J. Arenas et al.   BLOOD

The mechanistic target of rapamycin (mTOR): Novel Considerations as an Antiviral Treatment and Possibilities for COVID-19

(2020) Kenneth Maiese   CURRENT NEUROVASCULAR RESEARCH

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

Cell entry mechanisms of SARS-CoV-2

(2020) Jian Shang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic dysregulation of ACE2 and interferon-regulated genes might suggest increased COVID-19 susceptibility and severity in lupus patients

(2020) Amr H. Sawalha et al.   CLINICAL IMMUNOLOGY

Therapeutic blockade of inflammation in severe COVID-19 infection with intravenous N-acetylcysteine

(2020) Homam Ibrahim et al.   CLINICAL IMMUNOLOGY

Regulatory T Cell Stability and Migration Are Dependent on mTOR

(2020) Romain Vallion et al.   JOURNAL OF IMMUNOLOGY

An inflammatory cytokine signature predicts COVID-19 severity and survival

(2020) Diane Marie Del Valle et al.   NATURE MEDICINE

Regulation of Dendritic Cell Immune Function and Metabolism by Cellular Nutrient Sensor Mammalian Target of Rapamycin (mTOR)

(2019) Julia P. Snyder et al.   Frontiers in Immunology

Identifying and targeting pathogenic PI3K/AKT/mTOR signaling in IL-6 blockade–refractory idiopathic multicentric Castleman disease

(2019) David C. Fajgenbaum et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting the mechanistic target of rapamycin complex 1 restricts pro‐inflammatory T cell differentiation and ameliorates Takayasu's arteritis

(2019) Jifeng Zhang et al.   Arthritis & Rheumatology

Low-Dose Sirolimus Immunoregulation Therapy in Patients with Active Rheumatoid Arthritis: A 24-Week Follow-Up of the Randomized, Open-Label, Parallel-Controlled Trial

(2019) Hong-Yan Wen et al.   Journal of Immunology Research

Sirolimus in patients with clinically active systemic lupus erythematosus resistant to, or intolerant of, conventional medications: a single-arm, open-label, phase 1/2 trial

(2018) Zhi-Wei Lai et al.   LANCET

Effects of rapamycin on growth hormone receptor knockout mice

(2018) Yimin Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TORC1 inhibition enhances immune function and reduces infections in the elderly

(2018) Joan B. Mannick et al.   Science Translational Medicine

Phosphorylation of ULK1 affects autophagosome fusion and links chaperone-mediated autophagy to macroautophagy

(2018) Chenyao Wang et al.   Nature Communications

ETV7 is an essential component of a rapamycin-insensitive mTOR complex in cancer

(2018) Franklin C. Harwood et al.   Science Advances

Metabolic heterogeneity underlies reciprocal fates of TH17 cell stemness and plasticity

(2018) Peer W. F. Karmaus et al.   NATURE

Tregs restrain dendritic cell autophagy to ameliorate autoimmunity

(2017) Themis Alissafi et al.   JOURNAL OF CLINICAL INVESTIGATION

mTOR regulates metabolic adaptation of APCs in the lung and controls the outcome of allergic inflammation

(2017) Charles Sinclair et al.   SCIENCE

Activation of the Mechanistic Target of Rapamycin in SLE: Explosion of Evidence in the Last Five Years

(2016) Zachary Oaks et al.   Current Rheumatology Reports

mTORC1 and mTORC2 selectively regulate CD8+ T cell differentiation

(2015) Kristen N. Pollizzi et al.   JOURNAL OF CLINICAL INVESTIGATION

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Intersection of mTOR and STAT signaling in immunity

(2015) Diana Saleiro et al.   TRENDS IN IMMUNOLOGY

Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2

(2015) Yan Luo et al.   Oncotarget

Antiviral Potential of ERK/MAPK and PI3K/AKT/mTOR Signaling Modulation for Middle East Respiratory Syndrome Coronavirus Infection as Identified by Temporal Kinome Analysis

(2014) Jason Kindrachuk et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome

(2014) Suchithra Menon et al.   CELL

Toll-Like Receptor Signaling Pathways

(2014) Takumi Kawasaki et al.   Frontiers in Immunology

mTORC2 controls actin polymerization required for consolidation of long-term memory

(2013) Wei Huang et al.   NATURE NEUROSCIENCE

N-acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients: A randomized, double-blind, placebo-controlled trial

(2012) Zhi-Wei Lai et al.   ARTHRITIS AND RHEUMATISM

Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

(2012) Liron Bar-Peled et al.   CELL

mTOR, metabolism, and the regulation of T-cell differentiation and function

(2012) Adam T. Waickman et al.   IMMUNOLOGICAL REVIEWS

Metabolic switching and fuel choice during T-cell differentiation and memory development

(2012) Gerritje J. W. Windt et al.   IMMUNOLOGICAL REVIEWS

Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control

(2011) Robbie Loewith et al.   GENETICS

Evolution of the TOR Pathway

(2011) Teunis J. P. van Dam et al.   JOURNAL OF MOLECULAR EVOLUTION

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

(2010) Richard A. Miller et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Toll-like receptors in control of immunological autophagy

(2009) M A Delgado et al.   CELL DEATH AND DIFFERENTIATION

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

(2009) Greg M. Delgoffe et al.   IMMUNITY

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes

(2009) R. G. Jenner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

(2008) A. Y. Choo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA