Notum suppresses the osteogenic differentiation of periodontal ligament stem cells through the Wnt/Beta catenin signaling pathway

Osteoblast-derived NOTUM reduces cortical bone mass in mice and the NOTUM locus is associated with bone mineral density in humans

(2019) Sofia Movérare-Skrtic et al.   FASEB JOURNAL

New Insights about the Wnt/β-Catenin Signaling Pathway in Primary Bone Tumors and Their Microenvironment: A Promising Target to Develop Therapeutic Strategies?

(2019) Danieau et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium

(2019) Nalle Pentinmikko et al.   NATURE

Histone Methylation Mechanisms Modulate the Inflammatory Response of Periodontal Ligament Progenitors

(2019) Marybeth Francis et al.   STEM CELLS AND DEVELOPMENT

Muscone Promotes The Adipogenic Differentiation Of Human Gingival Mesenchymal Stem Cells By Inhibiting The Wnt/β-Catenin Signaling Pathway

(2019) Wen-Xiu Yuan et al.   Drug Design Development and Therapy

YAP balances the osteogenic and adipogenic differentiation of hPDLSCs in vitro partly through the Wnt/β-catenin signaling pathway

(2019) Linglu Jia et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

An experimental murine model to study periodontitis

(2018) Julie Marchesan et al.   Nature Protocols

4H-Thieno[3,2-c]chromene based inhibitors of Notum Pectinacetylesterase

(2016) Qiang Han et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Romosozumab Treatment in Postmenopausal Women with Osteoporosis

(2016) Felicia Cosman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dentin Dysplasia in Notum Knockout Mice

(2016) P. Vogel et al.   VETERINARY PATHOLOGY

Developmental Drift and the Role of Wnt Signaling in Aging

(2016) Jan Gruber et al.   Cancers

Notum Is Required for Neural and Head Induction via Wnt Deacylation, Oxidation, and Inactivation

(2015) Xinjun Zhang et al.   DEVELOPMENTAL CELL

Periodontitis promotes the proliferation and suppresses the differentiation potential of human periodontal ligament stem cells

(2015) WEI ZHENG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The WNT system: background and its role in bone

(2015) U. H. Lerner et al.   JOURNAL OF INTERNAL MEDICINE

Periodontitis as a risk factor for systemic disease: Are microparticles the missing link?

(2015) Zahi Badran et al.   MEDICAL HYPOTHESES

Notum deacylates Wnt proteins to suppress signalling activity

(2015) Satoshi Kakugawa et al.   NATURE

Disarming Wnt

(2015) Roel Nusse   NATURE

Periodontal Ligament Stem Cells: Current Status, Concerns, and Future Prospects

(2015) Wenjun Zhu et al.   Stem Cells International

WNT signaling in bone homeostasis and disease: from human mutations to treatments

(2013) Roland Baron et al.   NATURE MEDICINE

Update on Bone Anabolics in Osteoporosis Treatment: Rationale, Current Status, and Perspectives

(2012) Roland Baron et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

High levels of β-catenin signaling reduce osteogenic differentiation of stem cells in inflammatory microenvironments through inhibition of the noncanonical Wnt pathway

(2011) Na Liu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Isolation and characterization of human periodontal ligament (PDL) stem cells (PDLSCs) from the inflamed PDL tissue: in vitro and in vivo evaluations

(2011) Jung-Chul Park et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Differentiation of Neural-Crest-Derived Intermediate Pluripotent Progenitors into Committed Periodontal Populations Involves Unique Molecular Signature Changes, Cohort Shifts, and Epigenetic Modifications

(2010) Smit Jayant Dangaria et al.   STEM CELLS AND DEVELOPMENT

Apatite Microtopographies Instruct Signaling Tapestries for Progenitor-Driven New Attachment of Teeth

(2010) Smit J. Dangaria et al.   TISSUE ENGINEERING PART A

Extracellular matrix-mediated differentiation of periodontal progenitor cells

(2009) Smit J. Dangaria et al.   DIFFERENTIATION