Spatially Confined Intervention of Cellular Senescence by a Lysosomal Metabolism Targeting Molecular Prodrug for Broad‐Spectrum Senotherapy

Designer Anticancer Nanoprodrugs Featuring Self‐toxification Activity Realized by Acid‐triggered Biodegradation and in situ Fragments Complexation

(2021) Yannan Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Galacto‐conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity

(2020) Estela González‐Gualda et al.   AGING CELL

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Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice

(2020) Yusheng Cai et al.   CELL RESEARCH

Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span

(2020) Paul D. Robbins et al.   Annual Review of Pharmacology and Toxicology

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(2019) Beatriz Lozano-Torres et al.   Nature Reviews Chemistry

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

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(2018) Alejandra Hernandez-Segura et al.   TRENDS IN CELL BIOLOGY

Adjustment of the lysosomal-mitochondrial axis for control of cellular senescence

(2018) Joon Tae Park et al.   AGEING RESEARCH REVIEWS

The lysosome as a cellular centre for signalling, metabolism and quality control

(2018) Rosalie E. Lawrence et al.   NATURE CELL BIOLOGY

Senescent cells: an emerging target for diseases of ageing

(2017) Bennett G. Childs et al.   NATURE REVIEWS DRUG DISCOVERY

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(2016) Raquel Gómez-Sintes et al.   AGEING RESEARCH REVIEWS

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(2016) Reut Yosef et al.   Nature Communications

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

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Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

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(2014) Ana M. Villamil Giraldo et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

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(2014) Jan M. van Deursen   NATURE

Lysosomal Membrane Permeabilization by Targeted Magnetic Nanoparticles in Alternating Magnetic Fields

(2013) Maribella Domenech et al.   ACS Nano

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Sphingosine mediates TNFα-induced lysosomal membrane permeabilization and ensuing programmed cell death in hepatoma cells

(2012) Chiara Ullio et al.   JOURNAL OF LIPID RESEARCH

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

(2009) Paul Saftig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cysteine Cathepsins Trigger Caspase-dependent Cell Death through Cleavage of Bid and Antiapoptotic Bcl-2 Homologues

(2008) Gabriela Droga-Mazovec et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

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(2008) P Boya et al.   ONCOGENE