Journal
ANALYTICAL CHEMISTRY
Volume 93, Issue 49, Pages 16379-16384Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.1c02834
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The study introduces a novel approach that combines liquid chromatography with a high-resolution ion mobility mass spectrometry system to differentiate peptide and peptide fragments based on their mobility and mass.
The identification and localization of isomeric peptide modifications is a critical requirement of the biopharmaceutical industry. Despite the ability of liquid chromatography-mass spectrometry to identify many of the common post translational modifications, the identification of isobaric or racemized peptides is confounded by modern mass spectrometry-based techniques. Her; we present a novel approach combining liquid chromatography with a high-resolution ion mobility mass spectrometry system to differentiate peptide and peptide fragments based upon their mobility and mass.
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