Extending Native Top-Down Electron Capture Dissociation to MDa Immunoglobulin Complexes Provides Useful Sequence Tags Covering Their Critical Variable Complementarity-Determining Regions

Generating Informative Sequence Tags from Antigen-Binding Regions of Heavily Glycosylated IgA1 Antibodies by Native Top-Down Electron Capture Dissociation

(2021) Jean-Francois Greisch et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Staphylococcal protein A inhibits complement activation by interfering with IgG hexamer formation

(2021) Ana Rita Cruz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the human secretory immunoglobulin M core

(2021) Nikit Kumar et al.   STRUCTURE

Top-Down Characterization of Denatured Proteins and Native Protein Complexes Using Electron Capture Dissociation Implemented within a Modified Ion Mobility-Mass Spectrometer

(2020) Jonathan P. Williams et al.   ANALYTICAL CHEMISTRY

Structural insights into immunoglobulin M

(2020) Yaxin Li et al.   SCIENCE

Human Secretory IgM: An Elusive Player in Mucosal Immunity

(2020) Eva Michaud et al.   TRENDS IN IMMUNOLOGY

Using 10,000 fragment ions to inform scoring in native top-down proteomics

(2020) Ashley Ives et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Resolving heterogeneous macromolecular assemblies by Orbitrap-based single-particle charge detection mass spectrometry

(2020) Tobias P. Wörner et al.   NATURE METHODS

Simple and Minimally Invasive SID Devices for Native Mass Spectrometry

(2020) Dalton T. Snyder et al.   ANALYTICAL CHEMISTRY

Inter-laboratory Study for Characterizing Monoclonal Antibodies by Top-Down and Middle-Down Mass Spectrometry

(2020) Kristina Srzentic et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Native mass spectrometry imaging and in situ top-down identification of intact proteins directly from tissue

(2020) Oliver J. Hale et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Role of IgM and IgA Antibodies in the Neutralization of SARS-CoV-2

(2020) Jéromine Klingler et al.   JOURNAL OF INFECTIOUS DISEASES

Top-Down Analysis of Proteins in Low Charge States

(2019) Aarti Bashyal et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Direct Determination of Antibody Chain Pairing by Top-down and Middle-down Mass Spectrometry Using Electron Capture Dissociation and Ultraviolet Photodissociation

(2019) Jared B. Shaw et al.   ANALYTICAL CHEMISTRY

Charge Movement and Structural Changes in the Gas-Phase Unfolding of Multimeric Protein Complexes Captured by Native Top-Down Mass Spectrometry

(2019) Mowei Zhou et al.   ANALYTICAL CHEMISTRY

Carbamylation reduces the capacity of IgG for hexamerization and complement activation

(2019) R. Lubbers et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Application of network smoothing to glycan LC-MS profiling

(2018) Joshua Klein et al.   BIOINFORMATICS

Radical solutions: Principles and application of electron-based dissociation in mass spectrometry-based analysis of protein structure

(2018) Frederik Lermyte et al.   MASS SPECTROMETRY REVIEWS

An integrated native mass spectrometry and top-down proteomics method that connects sequence to structure and function of macromolecular complexes

(2018) Huilin Li et al.   Nature Chemistry

Chain Ejection Model for Electrospray Ionization of Unfolded Proteins: Evidence from Atomistic Simulations and Ion Mobility Spectrometry

(2018) Haidy Metwally et al.   ANALYTICAL CHEMISTRY

Sequencing Grade Tandem Mass Spectrometry for Top–Down Proteomics Using Hybrid Electron Capture Dissociation Methods in a Benchtop Orbitrap Mass Spectrometer

(2018) Jared B. Shaw et al.   ANALYTICAL CHEMISTRY

The IgM pentamer is an asymmetric pentagon with an open groove that binds the AIM protein

(2018) Emiri Hiramoto et al.   Science Advances

Exploring ECD on a Benchtop Q Exactive Orbitrap Mass Spectrometer

(2017) Kyle L. Fort et al.   JOURNAL OF PROTEOME RESEARCH

Structural Characterization of a Thrombin-Aptamer Complex by High Resolution Native Top-Down Mass Spectrometry

(2017) Jiang Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Top-down characterization of endogenous protein complexes with native proteomics

(2017) Owen S Skinner et al.   Nature Chemical Biology

Informed-Proteomics: open-source software package for top-down proteomics

(2017) Jungkap Park et al.   NATURE METHODS

Antibody Isotypes for Tumor Immunotherapy

(2017) Anna Kretschmer et al.   TRANSFUSION MEDICINE AND HEMOTHERAPY

Salt Bridge Rearrangement (SaBRe) Explains the Dissociation Behavior of Noncovalent Complexes

(2016) Rachel R. Ogorzalek Loo et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Molecular Basis of Assembly and Activation of Complement Component C1 in Complex with Immunoglobulin G1 and Antigen

(2016) Guanbo Wang et al.   MOLECULAR CELL

A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface

(2016) Rob N. de Jong et al.   PLOS BIOLOGY

Molecular Insights into the Thermal Stability of mAbs with Variable-Temperature Ion-Mobility Mass Spectrometry

(2015) Kamila J. Pacholarz et al.   CHEMBIOCHEM

Top-down mass spectrometry of intact membrane protein complexes reveals oligomeric state and sequence information in a single experiment

(2015) Albert Konijnenberg et al.   PROTEIN SCIENCE

Characterization of Native Protein Complexes Using Ultraviolet Photodissociation Mass Spectrometry

(2014) John P. O’Brien et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Complement Is Activated by IgG Hexamers Assembled at the Cell Surface

(2014) C. A. Diebolder et al.   SCIENCE

Native Top-Down Electrospray Ionization-Mass Spectrometry of 158 kDa Protein Complex by High-Resolution Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

(2013) Huilin Li et al.   ANALYTICAL CHEMISTRY

Top-Down Structural Analysis of an Intact Monoclonal Antibody by Electron Capture Dissociation-Fourier Transform Ion Cyclotron Resonance-Mass Spectrometry

(2013) Yuan Mao et al.   ANALYTICAL CHEMISTRY

Principles of electron capture and transfer dissociation mass spectrometry applied to peptide and protein structure analysis

(2013) Konstantin O. Zhurov et al.   CHEMICAL SOCIETY REVIEWS

Mass spectrometry for the biophysical characterization of therapeutic monoclonal antibodies

(2013) Hao Zhang et al.   FEBS LETTERS

A cross-platform toolkit for mass spectrometry and proteomics

(2012) Matthew C Chambers et al.   NATURE BIOTECHNOLOGY

Does Electron Capture Dissociation Cleave Protein Disulfide Bonds?

(2012) Barbara Ganisl et al.   ChemistryOpen

Estimating the Hydrogen Bond Energy

(2010) Katharina Wendler et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Native Electrospray and Electron-Capture Dissociation in FTICR Mass Spectrometry Provide Top-Down Sequencing of a Protein Component in an Intact Protein Assembly

(2010) Hao Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY