Methionine as a double-edged sword in health and disease: Current perspective and future challenges

Edaravone protects from memory impairment induced by chronic L-methionine administration

(2020) Karem H. Alzoubi et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

High levels of dietary methionine improves sitagliptin-induced hepatotoxicity by attenuating oxidative stress in hypercholesterolemic rats

(2020) Avinash Kumar et al.   Nutrition & Metabolism

Effect of different levels of dietary methionine restriction on relieving oxidative stress and behavioral deficits in middle-aged mice fed low-, medium-, or high-fat diet

(2020) Guoqing Wu et al.   Journal of Functional Foods

Methionine Restriction and Cancer Biology

(2020) Desiree Wanders et al.   Nutrients

Oral dosing of Recombinant Methioninase Is Associated With a 70% Drop in PSA in a Patient With Bone-metastatic Prostate Cancer and 50% Reduction in Circulating Methionine in a High-stage Ovarian Cancer Patient

(2020) QINGHONG HAN et al.   ANTICANCER RESEARCH

Methionine augments endogenous antioxidant capacity of rice protein through stimulating MSR antioxidant system and activating Nrf2-ARE pathway in growing and adult rats

(2020) Hui Li et al.   EUROPEAN FOOD RESEARCH AND TECHNOLOGY

Effects of dietary methionine and cysteine restriction on plasma biomarkers, serum fibroblast growth factor 21, and adipose tissue gene expression in women with overweight or obesity: a double-blind randomized controlled pilot study

(2020) Thomas Olsen et al.   Journal of Translational Medicine

DNA Methylation Biomarkers in Aging and Age-Related Diseases

(2020) Yasmeen Salameh et al.   Frontiers in Genetics

Methionine Restriction Alleviates High-Fat Diet-induced Obesity: Involvement of Diurnal Metabolism of Lipids and Bile Acids

(2020) Luanfeng Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mechanism of Activation of Mechanistic Target of Rapamycin Complex 1 by Methionine

(2020) Munehiro Kitada et al.   Frontiers in Cell and Developmental Biology

Histone methylation status of H3K4me3 and H3K9me3 under methionine restriction is unstable in methionine-addicted cancer cells, but stable in normal cells

(2020) Jun Yamamoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Quantitative determination of histone methylation via fluorescence resonance energy transfer (FRET) technology in immortalized bovine mammary alveolar epithelial cells supplemented with methionine

(2020) Fernanda Rosa et al.   PLoS One

Methionine restriction prevents onset of type 2 diabetes in NZO mice

(2019) Teresa Castaño-Martinez et al.   FASEB JOURNAL

Neuroprotective effects of zafirlukast, piracetam and their combination on L‐Methionine‐induced vascular dementia in rats

(2019) Ahmed M. Fayez et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Efficacy of Recombinant Methioninase (rMETase) on Recalcitrant Cancer Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models: A Review

(2019) Kawaguchi et al.   Cells

Methionine restriction delays senescence and suppresses the senescence-associated secretory phenotype in the kidney through endogenous hydrogen sulfide

(2019) Si-Yang Wang et al.   CELL CYCLE

Dietary Supplementation of Methyl Donor L‐Methionine Alters Epigenetic Modification in Type 2 Diabetes

(2019) Umashanker Navik et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Methionine restriction delays aging-related urogenital diseases in male Fischer 344 rats

(2019) Despina Komninou et al.   GeroScience

Regulators of the Transsulfuration Pathway

(2018) Juan I Sbodio et al.   BRITISH JOURNAL OF PHARMACOLOGY

Oral recombinant methioninase (o-rMETase) is superior to injectable rMETase and overcomes acquired gemcitabine resistance in pancreatic cancer

(2018) Kei Kawaguchi et al.   CANCER LETTERS

Dietary methionine restriction: Effects on glucose tolerance, lipid content and micro-RNA composition in the muscle of rainbow trout

(2018) M.N. Latimer et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width

(2018) Ziwei Dai et al.   Nature Communications

Metabolism and Neurotoxicity of Homocysteine Thiolactone in Mice: Evidence for a Protective Role of Paraoxonase 1

(2018) Kamila Borowczyk et al.   JOURNAL OF ALZHEIMERS DISEASE

Methionine and valine activate the mammalian target of rapamycin complex 1 pathway through heterodimeric amino acid taste receptor (TAS1R1/TAS1R3) and intracellular Ca2+ in bovine mammary epithelial cells

(2018) Y. Zhou et al.   JOURNAL OF DAIRY SCIENCE

Short term methionine restriction increases hepatic global DNA methylation in adult but not young male C57BL/6J mice

(2017) Dwight A.L. Mattocks et al.   EXPERIMENTAL GERONTOLOGY

Pleiotropic responses to methionine restriction

(2017) Gene P. Ables et al.   EXPERIMENTAL GERONTOLOGY

Homocysteine Induces Hepatic Steatosis Involving ER Stress Response in High Methionine Diet-Fed Mice

(2017) Yanbiao Ai et al.   Nutrients

Role of GCN2-Independent Signaling Through a Noncanonical PERK/NRF2 Pathway in the Physiological Responses to Dietary Methionine Restriction

(2016) Desiree Wanders et al.   DIABETES

Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice

(2016) Qi Gong et al.   HEPATOLOGY

Methionine-Restricted Diet Increases miRNAs That Can Target RUNX2 Expression and Alters Bone Structure in Young Mice

(2016) Jason Plummer et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Protective effects of maternal methyl donor supplementation on adult offspring of high fat diet-fed dams

(2016) Fei Jiao et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

High-Methionine Diet Attenuates Severity of Arthritis and Modulates IGF-I Related Gene Expressions in an Adjuvant Arthritis Rats Model

(2016) Mingxin Li et al.   MEDIATORS OF INFLAMMATION

Neuroprotective Effects of Simvastatin and Cilostazol in l-Methionine-Induced Vascular Dementia in Rats

(2016) Ahmed M. El-Dessouki et al.   MOLECULAR NEUROBIOLOGY

DNA methylation and healthy human aging

(2015) Meaghan J. Jones et al.   AGING CELL

Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism

(2015) Samantha J. Mentch et al.   Cell Metabolism

High-methionine diets accelerate atherosclerosis by HHcy-mediated FABP4 gene demethylation pathway via DNMT1 in ApoE−/−mice

(2015) An-Ning Yang et al.   FEBS LETTERS

A 4-Week Toxicity Study of Methionine in Male Rats

(2015) Keigi Chin et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

Methionine restriction restores a younger metabolic phenotype in adult mice with alterations in fibroblast growth factor 21

(2014) Emma K. Lees et al.   AGING CELL

Mechanisms of Increased In Vivo Insulin Sensitivity by Dietary Methionine Restriction in Mice

(2014) Kirsten P. Stone et al.   DIABETES

Development of recombinant methioninase to target the general cancer-specific metabolic defect of methionine dependence: a 40-year odyssey

(2014) Robert M Hoffman   EXPERT OPINION ON BIOLOGICAL THERAPY

A Methionine-Restricted Diet and Endurance Exercise Decrease Bone Mass and Extrinsic Strength but Increase Intrinsic Strength in Growing Male Rats

(2014) Tsang-Hai Huang et al.   JOURNAL OF NUTRITION

Dietary methionine restriction inhibits prostatic intraepithelial neoplasia in TRAMP mice

(2014) Raghu Sinha et al.   PROSTATE

Methyl-donor supplementation in obese mice prevents the progression of NAFLD, activates AMPK and decreases acyl-carnitine levels

(2014) Christoph Dahlhoff et al.   Molecular Metabolism

Methionine down-regulates TLR4/MyD88/NF-κB signalling in osteoclast precursors to reduce bone loss during osteoporosis

(2013) V Vijayan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Methionine restriction affects oxidative stress and glutathione-related redox pathways in the rat

(2013) Sreenivasa Maddineni et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Dietary supplementation with methyl donors reduces fatty liver and modifies the fatty acid synthase DNA methylation profile in rats fed an obesogenic diet

(2012) P. Cordero et al.   Genes and Nutrition

S-adenosylmethionine in Liver Health, Injury, and Cancer

(2012) Shelly C. Lu et al.   PHYSIOLOGICAL REVIEWS

Amino acids biosynthesis and nitrogen assimilation pathways: a great genomic deletion during eukaryotes evolution

(2011) RLM Guedes et al.   BMC GENOMICS

Sulfur amino acids in methionine-restricted rats: Hyperhomocysteinemia

(2010) Amany K. Elshorbagy et al.   NUTRITION

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Influence of Methionine upon the Concentration of Malondialdehyde in the Tissues and Blood of Rats Exposed to Sodium Fluoride

(2009) Iwona Błaszczyk et al.   BIOLOGICAL TRACE ELEMENT RESEARCH