Targeted drug delivery for maternal and perinatal health: Challenges and opportunities

Enhanced drug delivery to the reproductive tract using nanomedicine reveals therapeutic options for prevention of preterm birth

(2021) Hannah C. Zierden et al.   Science Translational Medicine

Dynamic placenta-on-a-chip model for fetal risk assessment of nanoparticles intended to treat pregnancy-associated diseases

(2021) Shahla Shojaei et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Trophoblast-Targeted Nanomedicine Modulates Placental sFLT1 for Preeclampsia Treatment

(2020) Lei Li et al.   Frontiers in Bioengineering and Biotechnology

Emerging Therapeutic Potential of Mesenchymal Stem/Stromal Cells in Preeclampsia

(2020) S. Suvakov et al.   CURRENT HYPERTENSION REPORTS

Confirmatory Trial for Drug to Prevent Preterm Birth Finds No Benefit, So Why Is It Still Prescribed?

(2020) Rita Rubin   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Contributions of maternal and fetal antiviral immunity in congenital disease

(2020) Laura J. Yockey et al.   SCIENCE

Targeting Mitochondria in Tumor-Associated Macrophages using a Dendrimer Conjugated TSPO Ligand Stimulates Anti-Tumor Signaling in Glioblastoma

(2020) Anjali Sharma et al.   BIOMACROMOLECULES

FDA approved vs. Pharmacy compounded 17-OHPC—current issues for obstetricians to consider in reducing recurrent preterm birth

(2020) David L. Gandell et al.   CURRENT MEDICAL RESEARCH AND OPINION

Clinical characteristics, prognostic factors, and maternal and neonatal outcomes of SARS‐CoV‐2 infection among hospitalized pregnant women: a systematic review

(2020) Ozlem Turan et al.   INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS

Megalin-targeting liposomes for placental drug delivery

(2020) Ali A. Alfaifi et al.   JOURNAL OF CONTROLLED RELEASE

Recent insights on indirect mechanisms in developmental toxicity of nanomaterials

(2020) Battuja Batbajar Dugershaw et al.   Particle and Fibre Toxicology

Exploiting the placenta for nanoparticle-mediated drug delivery during pregnancy

(2020) Christian G. Figueroa-Espada et al.   ADVANCED DRUG DELIVERY REVIEWS

Association of Prenatal Alcohol Exposure With Psychological, Behavioral, and Neurodevelopmental Outcomes in Children From the Adolescent Brain Cognitive Development Study

(2020) Briana Lees et al.   AMERICAN JOURNAL OF PSYCHIATRY

Comprehensive Assessment of the Associations between Maternal Diabetes and Structural Birth Defects in Offspring: A Phenome-Wide Association Study

(2020) Jeremy M. Schraw et al.   ANNALS OF EPIDEMIOLOGY

Delivering the power of nanomedicine to patients today

(2020) Matthieu Germain et al.   JOURNAL OF CONTROLLED RELEASE

Human placental uptake of glutamine and glutamate is reduced in fetal growth restriction

(2020) Kirsty R. McIntyre et al.   Scientific Reports

Nanoparticle-Mediated Simultaneous Downregulation of Placental Nrf2 and sFlt1 Improves Maternal and Fetal Outcomes in a Preeclampsia Mouse Model

(2020) Lei Li et al.   ACS Biomaterials-Science & Engineering

Systemic dendrimer delivery of triptolide to tumor-associated macrophages improves anti-tumor efficacy and reduces systemic toxicity in glioblastoma

(2020) Kevin Liaw et al.   JOURNAL OF CONTROLLED RELEASE

Trophoblast damage with acute and chronic intervillositis: disruption of the placental barrier by severe acute respiratory syndrome coronavirus 2

(2020) Larisa Debelenko et al.   HUMAN PATHOLOGY

Teratogenicity of antiepileptic drugs

(2019) Torbjörn Tomson et al.   CURRENT OPINION IN NEUROLOGY

Sex-dependent behavioral deficits and neuropathology in a maternal immune activation model of autism

(2019) Obelia Haida et al.   Translational Psychiatry

Management of epilepsy in women

(2019) Linda J Stephen et al.   LANCET NEUROLOGY

In utero gene editing for monogenic lung disease

(2019) Deepthi Alapati et al.   Science Translational Medicine

Neonatal Abstinence Syndrome and Associated Neonatal and Maternal Mortality and Morbidity

(2019) Sarka Lisonkova et al.   PEDIATRICS

Neonatal brain-directed gene therapy rescues a mouse model of neurodegenerative CLN6 Batten disease

(2019) Sophia-Martha kleine Holthaus et al.   HUMAN MOLECULAR GENETICS

Prenatal stem cell therapy for inherited diseases: Past, present, and future treatment strategies: Concise Review

(2019) Åsa Ekblad‐Nordberg et al.   Stem Cells Translational Medicine

Toxic effects of maternal exposure to silver nanoparticles on mice fetal development during pregnancy

(2019) Maryam Mozafari et al.   Birth Defects Research

Nanoparticle Contrast-enhanced T1-Mapping Enables Estimation of Placental Fractional Blood Volume in a Pregnant Mouse Model

(2019) Andrew A. Badachhape et al.   Scientific Reports

Protective effect of human umbilical cord mesenchymal stem cell exosomes on preserving the morphology and angiogenesis of placenta in rats with preeclampsia

(2018) Zhi-Hui Xiong et al.   BIOMEDICINE & PHARMACOTHERAPY

Antibodies and methods for immunohistochemistry of extracellular matrix proteins

(2018) Steffen Rickelt et al.   MATRIX BIOLOGY

Fetal gene therapy for neurodegenerative disease of infants

(2018) Giulia Massaro et al.   NATURE MEDICINE

Maternal substance use during pregnancy and offspring conduct problems: A meta-analysis

(2018) I. Hyun Ruisch et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Gene Editing on Center Stage

(2018) Rasmus O. Bak et al.   TRENDS IN GENETICS

In utero nanoparticle delivery for site-specific genome editing

(2018) Adele S. Ricciardi et al.   Nature Communications

Placenta-specific drug delivery by trophoblast-targeted nanoparticles in mice

(2018) Baozhen Zhang et al.   Theranostics

Developmental Toxicity of Nanomaterials: Need for a Better Understanding of Indirect Effects

(2018) Tina Buerki-Thurnherr et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Regulation of Placental Development and Its Impact on Fetal Growth—New Insights From Mouse Models

(2018) Laura Woods et al.   Frontiers in Endocrinology

In utero CRISPR-mediated therapeutic editing of metabolic genes

(2018) Avery C. Rossidis et al.   NATURE MEDICINE

Cognitive impairments induced by necrotizing enterocolitis can be prevented by inhibiting microglial activation in mouse brain

(2018) Diego F. Niño et al.   Science Translational Medicine

Therapeutic benefit of mesenchymal stem cells in pregnant rats with angiotensin receptor agonistic autoantibody-induced hypertension: Implications for immunomodulation and cytoprotection

(2017) Dan Zhang et al.   HYPERTENSION IN PREGNANCY

Maternal Use of Antiepileptic Agents During Pregnancy and Major Congenital Malformations in Children

(2017) Rebecca L. Bromley et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Preterm Birth and Risk of Heart Failure Up to Early Adulthood

(2017) Hanna Carr et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Impact of particle size and surface modification on gold nanoparticle penetration into human placental microtissues

(2017) Carina Muoth et al.   Nanomedicine

Developmental origins of health and disease: current knowledge and potential mechanisms

(2017) Daniel J Hoffman et al.   NUTRITION REVIEWS

Transamniotic stem cell therapy: a novel strategy for the prenatal management of congenital anomalies

(2017) Dario O Fauza   PEDIATRIC RESEARCH

Pre-clinical evaluation of a nanoparticle-based blood-pool contrast agent for MR imaging of the placenta

(2017) Ketan B. Ghaghada et al.   PLACENTA

Modulating circulating sFlt1 in an animal model of preeclampsia using PAMAM nanoparticles for siRNA delivery

(2017) Jun Yu et al.   PLACENTA

The effects of pravastatin on the normal human placenta: Lessons from ex-vivo models

(2017) Adelina Balan et al.   PLoS One

Effects of engineered nanoparticles on the innate immune system

(2017) Yuanchang Liu et al.   SEMINARS IN IMMUNOLOGY

Maternal-placental-fetal biodistribution of multimodal polymeric nanoparticles in a pregnant rat model in mid and late gestation

(2017) Diwei Ho et al.   Scientific Reports

Selective Targeting of a Novel Vasodilator to the Uterine Vasculature to Treat Impaired Uteroplacental Perfusion in Pregnancy

(2017) Natalie Cureton et al.   Theranostics

Integration and validation of the ex vivo human placenta perfusion model

(2017) Sigrid Conings et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Maternal dendrimer-based therapy for inflammation-induced preterm birth and perinatal brain injury

(2017) Jun Lei et al.   Scientific Reports

PEGylation as a strategy for improving nanoparticle-based drug and gene delivery

(2016) Jung Soo Suk et al.   ADVANCED DRUG DELIVERY REVIEWS

Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise

(2016) Jonathan J. Miner et al.   CELL

Etiopathogenesis, prediction, and prevention of preeclampsia

(2016) P. J. Correa et al.   HYPERTENSION IN PREGNANCY

Epidemiology of hypertensive disorders in pregnancy: prevalence, risk factors, predictors and prognosis

(2016) Mitsumasa Umesawa et al.   HYPERTENSION RESEARCH

Surface functionality affects the biodistribution and microglia-targeting of intra-amniotically delivered dendrimers

(2016) Fan Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Vaginal progesterone prophylaxis for preterm birth (the OPPTIMUM study): a multicentre, randomised, double-blind trial

(2016) Jane Elizabeth Norman et al.   LANCET

Zika virus — reigniting the TORCH

(2016) Carolyn B. Coyne et al.   NATURE REVIEWS MICROBIOLOGY

Neonatal Abstinence Syndrome

(2016) Karen McQueen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effect of Human Umbilical Cord Mesenchymal Stem Cell Transplantation in a Rat Model of Preeclampsia

(2016) Lei-Lei Wang et al.   Reproductive Sciences

Uterus-targeted liposomes for preterm labor management: studies in pregnant mice

(2016) Jerrie S. Refuerzo et al.   Scientific Reports

Placental Responses to Changes in the Maternal Environment Determine Fetal Growth

(2016) Kris Genelyn Dimasuay et al.   Frontiers in Physiology

Tumor-homing peptides as tools for targeted delivery of payloads to the placenta

(2016) A. King et al.   Science Advances

A liposomal Gd contrast agent does not cross the mouse placental barrier

(2016) Anil N. Shetty et al.   Scientific Reports

Progress and future of in vitro models to study translocation of nanoparticles

(2015) Hedwig M. Braakhuis et al.   ARCHIVES OF TOXICOLOGY

TORCH Infections

(2015) Natalie Neu et al.   CLINICS IN PERINATOLOGY

Bidirectional Transfer Study of Polystyrene Nanoparticles across the Placental Barrier in an ex Vivo Human Placental Perfusion Model

(2015) Stefanie Grafmueller et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Association of Maternal Diabetes With Autism in Offspring

(2015) Anny H. Xiang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Gestational nanomaterial exposures: microvascular implications during pregnancy, fetal development and adulthood

(2015) P. A. Stapleton   JOURNAL OF PHYSIOLOGY-LONDON

Distribution and accumulation of 10 nm silver nanoparticles in maternal tissues and visceral yolk sac of pregnant mice, and a potential effect on embryo growth

(2015) Carlye A. Austin et al.   Nanotoxicology

Principles of nanoparticle design for overcoming biological barriers to drug delivery

(2015) Elvin Blanco et al.   NATURE BIOTECHNOLOGY

Increasing Incidence of the Neonatal Abstinence Syndrome in U.S. Neonatal ICUs

(2015) Veeral N. Tolia et al.   NEW ENGLAND JOURNAL OF MEDICINE

Development of Non-Viral, Trophoblast-Specific Gene Delivery for Placental Therapy

(2015) Noura Abd Ellah et al.   PLoS One

A Technique for the Estimation of Fractional Moving Blood Volume by Using Three-dimensional Power Doppler US

(2015) Gordon N. Stevenson et al.   RADIOLOGY

Pharmacokinetics of drugs in pregnancy

(2015) Maisa Feghali et al.   SEMINARS IN PERINATOLOGY

Translocation of positively and negatively charged polystyrene nanoparticles in an in vitro placental model

(2015) Samantha K. Kloet et al.   TOXICOLOGY IN VITRO

A New Approach to Reduce Toxicities and to Improve Bioavailabilities of Platinum-Containing Anti-Cancer Nanodrugs

(2015) Li Liu et al.   Scientific Reports

Mortality and Morbidity During Delivery Hospitalization Among Pregnant Women With Epilepsy in the United States

(2015) Sarah C. MacDonald et al.   JAMA Neurology

Breast Cancer Diagnosed During Pregnancy

(2015) Sibylle Loibl et al.   JAMA Oncology

Understanding the Complexity of the Immune System during Pregnancy

(2014) Karen Racicot et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Nanoparticle-based drug delivery to the vagina: A review

(2014) Laura M. Ensign et al.   JOURNAL OF CONTROLLED RELEASE

Imaging of activated complement using ultrasmall superparamagnetic iron oxide particles (USPIO) - conjugated vectors: an in vivo in utero non-invasive method to predict placental insufficiency and abnormal fetal brain development

(2014) G Girardi et al.   MOLECULAR PSYCHIATRY

Maternal immune activation and abnormal brain development across CNS disorders

(2014) Irene Knuesel et al.   Nature Reviews Neurology

Size dependent translocation and fetal accumulation of gold nanoparticles from maternal blood in the rat

(2014) Manuela Semmler-Behnke et al.   Particle and Fibre Toxicology

Long-Term Neurodevelopmental Outcome s After Preterm Birth

(2014) Farin Soleimani et al.   Iranian Red Crescent Medical Journal

Global causes of maternal death: a WHO systematic analysis

(2014) Lale Say et al.   Lancet Global Health

Placental ABC transporters, cellular toxicity and stress in pregnancy

(2013) Irving L.M.H. Aye et al.   CHEMICO-BIOLOGICAL INTERACTIONS

In utero hematopoietic cell transplantation—recent progress and the potential for clinical application

(2013) Jesse D. Vrecenak et al.   CYTOTHERAPY

Targeted Nanoparticle Delivery of Doxorubicin Into Placental Tissues to Treat Ectopic Pregnancies

(2013) Tu'uhevaha J. Kaitu'u-Lino et al.   ENDOCRINOLOGY

The Effects of Nanomaterials as Endocrine Disruptors

(2013) Ivo Iavicoli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Preparation, characterization, and transport of dexamethasone-loaded polymeric nanoparticles across a human placental in vitro model

(2013) Hazem Ali et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Kinetics of silica nanoparticles in the human placenta

(2013) Marie Sønnegaard Poulsen et al.   Nanotoxicology

The toxicity, transport and uptake of nanoparticles in thein vitroBeWo b30 placental cell barrier model used within NanoTEST

(2013) Sara Correia Carreira et al.   Nanotoxicology

Biodistribution and toxicity of pegylated single wall carbon nanotubes in pregnant mice

(2013) Luisa Campagnolo et al.   Particle and Fibre Toxicology

Effect of lipid composition of cationic SUV liposomes on materno-fetal transfer of warfarin across the perfused human term placenta

(2013) R. Bajoria et al.   PLACENTA

Intrauterine Inflammation Increases Materno-Fetal Transfer of Gold Nanoparticles in a Size-Dependent Manner in Murine Pregnancy

(2013) Xin Tian et al.   Small

Neonatal Drug Withdrawal

(2012) M. L. Hudak et al.   PEDIATRICS

Dendrimer-Based Postnatal Therapy for Neuroinflammation and Cerebral Palsy in a Rabbit Model

(2012) S. Kannan et al.   Science Translational Medicine

Effects of gestational age and surface modification on materno-fetal transfer of nanoparticles in murine pregnancy

(2012) Hui Yang et al.   Scientific Reports

Medication use during pregnancy, with particular focus on prescription drugs: 1976-2008

(2011) Allen A. Mitchell et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

IgG Placental Transfer in Healthy and Pathological Pregnancies

(2011) Patricia Palmeira et al.   Clinical & Developmental Immunology

Distribution of silver nanoparticles in pregnant mice and developing embryos

(2011) Carlye A. Austin et al.   Nanotoxicology

Pulmonary exposure to carbon black by inhalation or instillation in pregnant mice: Effects on liver DNA strand breaks in dams and offspring

(2011) Petra Jackson et al.   Nanotoxicology

Silica and titanium dioxide nanoparticles cause pregnancy complications in mice

(2011) Kohei Yamashita et al.   Nature Nanotechnology

Fetal Alcohol Spectrum Disorders: An Overview

(2011) Edward P. Riley et al.   NEUROPSYCHOLOGY REVIEW

The Risk of Necrotizing Enterocolitis After Indomethacin Tocolysis

(2011) B. G. Sood et al.   PEDIATRICS

Prenatal origin of obesity and their complications: Gestational diabetes, maternal overweight and the paradoxical effects of fetal growth restriction and macrosomia

(2011) Asher Ornoy   REPRODUCTIVE TOXICOLOGY

Transport of Nanoparticles through the Placental Barrier

(2011) Vytautas Kulvietis et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Relative and absolute addressability of global disease burden in maternal and perinatal health by investment in R&D

(2011) Nicholas M. Fisk et al.   TROPICAL MEDICINE & INTERNATIONAL HEALTH

The Immune System in Pregnancy: A Unique Complexity

(2010) Gil Mor et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Transport and biodistribution of dendrimers across human fetal membranes: Implications for intravaginal administration of dendrimer-drug conjugates

(2010) Anupa R. Menjoge et al.   BIOMATERIALS

Inhibition of bacterial growth and intramniotic infection in a guinea pig model of chorioamnionitis using PAMAM dendrimers

(2010) Bing Wang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Gestational age and dose influence on placental transfer of 63Ni in rats

(2010) X.-W. Wang et al.   PLACENTA

Transfer of Quantum Dots from Pregnant Mice to Pups Across the Placental Barrier

(2010) Maoquan Chu et al.   Small

Reproducibility of regional placental vascularity/perfusion measurement using 3D power Doppler

(2010) P. K. Lai et al.   ULTRASOUND IN OBSTETRICS & GYNECOLOGY

Prenatal Stem Cell Transplantation and Gene Therapy

(2009) Matthew T. Santore et al.   CLINICS IN PERINATOLOGY

Minireview: Nanoparticles and the Immune System

(2009) Banu S. Zolnik et al.   ENDOCRINOLOGY

Barrier Capacity of Human Placenta for Nanosized Materials

(2009) Peter Wick et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Drug use in pregnancy; a point to ponder!

(2009) Punam Sachdeva et al.   INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES

Nanoparticles Transferred from Pregnant Mice to Their Offspring Can Damage the Genital and Cranial Nerve Systems

(2009) Ken Takeda et al.   JOURNAL OF HEALTH SCIENCE

Loss of functional K+channels encoded byether-à-go-go-relatedgenes in mouse myometrium prior to labour onset

(2009) I. A. Greenwood et al.   JOURNAL OF PHYSIOLOGY-LONDON

Understanding biophysicochemical interactions at the nano–bio interface

(2009) Andre E. Nel et al.   NATURE MATERIALS

Prenatal exposure to drugs: effects on brain development and implications for policy and education

(2009) Barbara L. Thompson et al.   NATURE REVIEWS NEUROSCIENCE

Transplacental transport of nanomaterials

(2009) Margaret Saunders   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

The effect of surface functionality on cellular trafficking of dendrimers

(2008) Omathanu P. Perumal et al.   BIOMATERIALS

Association of Intrauterine Exposure to Maternal Diabetes and Obesity With Type 2 Diabetes in Youth: The SEARCH Case-Control Study

(2008) D. Dabelea et al.   DIABETES CARE

Kinetics of gold nanoparticles in the human placenta

(2008) Päivi K. Myllynen et al.   REPRODUCTIVE TOXICOLOGY

Prevalence of pre-existing diabetes in pregnancy doubled in seven years in a Californian population

(2008) David Spurgeon   BMJ-British Medical Journal

Market Failure and the Poverty of New Drugs in Maternal Health

(2008) Nicholas M Fisk et al.   PLOS MEDICINE

Gene therapy for the fetus: is there a future?

(2007) Anna L. David et al.   BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY