Article
Chemistry, Multidisciplinary
Liming Li, Jiafu Mu, Yu Zhang, Chenyang Zhang, Teng Ma, Lu Chen, Tianchen Huang, Jiahe Wu, Jian Cao, Shiqing Feng, Youzhi Cai, Min Han, Jianqing Gao
Summary: This study found that exosomes derived from hypoxic preconditioned human umbilical vein endothelial cells can stimulate angiogenic MSCs, showing great potential in the treatment of traumatic spinal cord injury.
Article
Cell & Tissue Engineering
Li Han, Zhirong Zhao, Xingyun Chen, Ke Yang, Zhen Tan, Zhu Huang, Lichen Zhou, Ruiwu Dai
Summary: In this study, it was found that human umbilical cord mesenchymal stem cells-exosomes (hucMSC-Exs) can colonize injured pancreatic tissue and facilitate the repair of pancreatic tissue by inhibiting cell apoptosis and controlling inflammatory response.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell & Tissue Engineering
Qingxi Qu, Linghong Liu, Yuqian Cui, Hongli Liu, Jingyang Yi, Weidong Bing, Chunxiao Liu, Detian Jiang, Yanwen Bi
Summary: miR-126-3p-hucMSCs-exosomes promote proliferation and inhibit apoptosis of ovarian granulosa cells, suggesting a potential therapeutic strategy for premature ovarian failure (POF) treatment.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Genetics & Heredity
Yan Jiang, Ting Luo, Qiang Xia, Jinhua Tian, Jing Yang
Summary: This study unraveled the mechanism of action of miR-140-5p transferred by exosomes released from human umbilical cord mesenchymal stem cells (huc-MSCs-EXO) in preeclampsia (PE). It was found that miR-140-5p suppressed PE by repressing FSTL3. Furthermore, huc-MSCs-EXO promoted biological functions and angiogenesis while inhibiting inflammation in hypoxic trophoblast cells.
FUNCTIONAL & INTEGRATIVE GENOMICS
(2022)
Article
Biochemistry & Molecular Biology
Hala M. ElBadre, Sahar E. M. El-Deek, Haidi Karam-Allah Ramadan, Mohamed M. Elbadr, Dina Sabry, Noran M. Ahmed, Amr M. Ahmed, Reham El-Mahdy
Summary: In this study, the effects of umbilical cord mesenchymal stem cells (UC-MSCs) derived exosomes on HepG2 cell line and the underlying mechanism of controlling hepatocellular carcinoma (HCC) proliferation were investigated. The results showed that treatment with exosomes significantly reduced the survival of HepG2 cells and altered the expression levels of SIRT-1, SDF-1, CXCR-4, TNF-α, and caspase-3. Furthermore, the anti-proliferative, apoptotic, and anti-angiogenic effects of exosomes on HepG2 cells were time-dependent. These findings suggest that exosomes could be a potential novel therapy for HCC, but further large-scale studies are needed to confirm this conclusion.
Article
Biochemistry & Molecular Biology
Jie Feng, Wei He, Jian Xia, Qing Huang, Jie Yang, Wen-Ping Gu, Ning Zhang, Yun-Hai Liu
Summary: Accumulating evidence suggests that human umbilical cord mesenchymal stem cell-derived exosomes (hUC-MSCs-Exos) are a promising therapeutic strategy for cerebral ischemia-reperfusion injury (CIRI). By transferring exosomal circDLGAP4, hUC-MSCs-Exos increased the expression levels of circDLGAP4 and KLF5 but decreased miR-320 in HBMECs, thereby reducing cerebrovascular injury caused by CIRI.
Article
Oncology
Litao Yan, Gejun Liu, Xing Wu
Summary: This study found that exosomal lncRNA H19 derived from UMSCs acts as a competing endogenous RNA to enhance osteochondral activity in chondrocytes by sequestering miR-29b-3p. Injection of exosomes overexpressing H19 promoted sustained cartilage repair, highlighting its potential for developing strategies against cartilage defects.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Shichao Wang, Wenyue Jiang, Shuang Lv, Zhicheng Sun, Lihui Si, Jinxin Hu, Yang Yang, Dingbang Qiu, Xiaobin Liu, Siying Zhu, Lunhao Yang, Ling Qi, Guangfan Chi, Guiqing Wang, Pengdong Li, Baojian Liao
Summary: This study confirms the anti-inflammatory effects of human umbilical cord-derived mesenchymal stem cell exosomes (hUC-MSCs-Exos) in the treatment of chondrocyte inflammation, suggesting their potential as a cell-free treatment strategy for osteoarthritis.
Article
Cell & Tissue Engineering
Mian Wu, Lifeng Chen, Yuhan Qi, Hai Ci, Shan Mou, Jie Yang, Qiaoyu Yuan, Weiqi Yao, Zhenxing Wang, Jiaming Sun
Summary: Using umbilical cord mesenchymal stem cells (hUCMSCs) as seed cells for tissue-engineered breast construction has shown significant advantages, promoting adipose tissue regeneration and enhancing angiogenesis. The transplantation of hUCMSCs was found to increase fat tissue content, reduce macrophage numbers, and exhibit good differentiation capability in adipose tissue.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Nanoscience & Nanotechnology
Qin Huang, Meng Gong, Tuantuan Tan, Yunong Lin, Yan Bao, Cuifang Fan
Summary: This study reveals that exosomal miR-18b-3p from human umbilical cord mesenchymal stem cells (hucMSCs) is involved in the occurrence and development of preeclampsia (PE) by targeting leptin (LEP). The upregulation of miR-18b-3p or treatment with exosomes suppresses LEP expression and reduces PE incidence, while downregulation of miR-18b-3p has the opposite effect. These findings provide valuable insights into the mechanism and potential treatment options for PE.
NANOSCALE RESEARCH LETTERS
(2021)
Article
Medicine, Research & Experimental
Xinwen Chang, Qizhi He, Mengtian Wei, Linyan Jia, Yingying Wei, Yiding Bian, Tao Duan, Kai Wang
Summary: Exosomes derived from human umbilical cord mesenchymal stem cells (HUCMSCs) have beneficial effects on adverse birth outcomes in a preeclampsia mouse model induced by sFlt-1. They can decrease blood pressure, improve fetal birth weight, and restore placental vascular networks. In addition, HUCMSC-exos partially rescue sFlt-1-induced dysfunction of human umbilical vein endothelial cells.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Cell Biology
Shi-Wei Ren, Guang-Qing Cao, Qing-Run Zhu, Min-Gang He, Fang Wu, Su-Mei Kong, Zhao-Yan Zhang, Qiang Wang, Feng Wang
Summary: This study investigated the function of exosomes derived from human umbilical cord mesenchymal stem cells (HUC-MSCs) in the treatment of postmenopausal osteoporosis. It was found that exosomes can enhance osteogenesis and cell proliferation, with the AKT signaling pathway playing an important role.
Review
Pharmacology & Pharmacy
Yang Zhang, Yanqi Zhong, Li Zou, Xiaoxia Liu
Summary: Well-developed placenta plays a fundamental role in successful pregnancy, while defective placental development is the underlying cause of preeclampsia. Placenta-derived mesenchymal stem cells (PMSCs) have the ability to differentiate into vessel wall cells and improve placental vasculature, artery remodeling, and immunoregulation. Recent studies have shown that preeclamptic PMSCs disrupt the balance and development in the placenta. However, transplantation or exosome therapies of PMSCs tend to improve placental vascular network and trophoblastic functions, suggesting a potential therapeutic strategy for preeclampsia.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Obstetrics & Gynecology
Minkai Cao, Juan Wen, Chaozhi Bu, Chunyan Li, Yu Lin, Hong Zhang, Yanfang Gu, Zhonghua Shi, Yan Zhang, Wei Long, Le Zhang
Summary: Exosomal circRNAs from umbilical cord blood play important roles in the pathogenesis of PE, with differential expression profiles identified in patients compared to normal controls. Bioinformatics analysis revealed enrichment of circRNA parental genes in metabolic regulation, trophoblast growth, and invasion, highlighting their significance in PE development.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Cell & Tissue Engineering
Yi-Chao Ye, Zhe-Han Chang, Peng Wang, You-Wei Wang, Jun Liang, Chong Chen, Jing-Jing Wang, Hong-Tao Sun, Yi Wang, Xiao-Hong Li
Summary: This study demonstrated that infarct-preconditioned exosomes enhanced vascular endothelial remodeling, promoting neurological recovery and reducing brain damage after stroke.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)