BAP1 loss augments sensitivity to BET inhibitors in cancer cells

Uveal melanoma

(2020) Martine J. Jager et al.   Nature Reviews Disease Primers

Genomic profiling in renal cell carcinoma

(2020) Nazli Dizman et al.   Nature Reviews Nephrology

Biological Mechanisms and Clinical Significance of BAP1 Mutations in Human Cancer

(2020) Michele Carbone et al.   Cancer Discovery

BAP1 deletion abrogates growth and metastasis of murine cutaneous melanoma

(2020) Xin Luo et al.   MELANOMA RESEARCH

BAP1 complex promotes transcription by opposing PRC1-mediated H2A ubiquitylation

(2019) Antoine Campagne et al.   Nature Communications

Regulation of H2A ubiquitination and SLC7A11 expression by BAP1 and PRC1

(2019) Yilei Zhang et al.   CELL CYCLE

BAP1 regulates epigenetic switch from pluripotency to differentiation in developmental lineages giving rise to BAP1-mutant cancers

(2019) Jeffim N. Kuznetsov et al.   Science Advances

Melanoma subtypes: Genomic profiles, prognostic molecular markers and therapeutic possibilities

(2018) Roy Rabbie et al.   JOURNAL OF PATHOLOGY

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains

(2018) Jean-Philippe Lambert et al.   MOLECULAR CELL

Functions of bromodomain-containing proteins and their roles in homeostasis and cancer

(2017) Takao Fujisawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer

(2016) Shaokun Shu et al.   NATURE

Erratum: Near-optimal probabilistic RNA-seq quantification

(2016) Nicolas L Bray et al.   NATURE BIOTECHNOLOGY

Uveal melanoma cells are resistant to EZH2 inhibition regardless of BAP1 status

(2016) Marie Schoumacher et al.   NATURE MEDICINE

BAP1 Has a Survival Role in Cutaneous Melanoma

(2015) Raj Kumar et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Loss of BAP1 function leads to EZH2-dependent transformation

(2015) Lindsay M LaFave et al.   NATURE MEDICINE

Targeting BET bromodomains for cancer treatment

(2015) Marie Jung et al.   Epigenomics

BRD4-targeted therapy induces Myc-independent cytotoxicity in Gnaq/11-mutatant uveal melanoma cells

(2015) Grazia Ambrosini et al.   Oncotarget

Lack of BAP1 protein expression in uveal melanoma is associated with increased metastatic risk and has utility in routine prognostic testing

(2014) H Kalirai et al.   BRITISH JOURNAL OF CANCER

Mutant Gq/11 Promote Uveal Melanoma Tumorigenesis by Activating YAP

(2014) Fa-Xing Yu et al.   CANCER CELL

Targeting bromodomains: epigenetic readers of lysine acetylation

(2014) Panagis Filippakopoulos et al.   NATURE REVIEWS DRUG DISCOVERY

Genome-wide localization of small molecules

(2013) Lars Anders et al.   NATURE BIOTECHNOLOGY

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair

(2013) H. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins

(2012) W. W. Lockwood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone Deacetylase Inhibitors Induce Growth Arrest and Differentiation in Uveal Melanoma

(2011) S. Landreville et al.   CLINICAL CANCER RESEARCH

KOBAS 2.0: a web server for annotation and identification of enriched pathways and diseases

(2011) Chen Xie et al.   NUCLEIC ACIDS RESEARCH

Targeting MYC dependence in cancer by inhibiting BET bromodomains

(2011) J. A. Mertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Frequent Mutation of BAP1 in Metastasizing Uveal Melanomas

(2010) J. W. Harbour et al.   SCIENCE

Role of polycomb proteins Ring1A and Ring1Bin the epigenetic regulation of gene expression

(2009) Miguel Vidal   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY