Scratching the Surface of the Protein Corona: Challenging Measurements and Controversies

Environmental dimensions of the protein corona

(2021) Korin E. Wheeler et al.   Nature Nanotechnology

The Protein Corona Does Not Influence Receptor-Mediated Targeting of Virus-like Particles

(2020) Jirina Zackova Suchanova et al.   BIOCONJUGATE CHEMISTRY

Toward Diffusion Measurements of Colloidal Nanoparticles in Biological Environments by Nuclear Magnetic Resonance

(2020) Daniel Padro et al.   Small

The Nanomaterial Metabolite Corona Determined Using a Quantitative Metabolomics Approach: A Pilot Study

(2020) Andrew J. Chetwynd et al.   Small

Preparation of the protein corona: How washing shapes the proteome and influences cellular uptake of nanocarriers

(2020) Maximilian Brückner et al.   Acta Biomaterialia

Size Measurement of Extracellular Vesicles and Synthetic Liposomes: The Impact of the Hydration Shell and the Protein Corona

(2020) Zoltán Varga et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Protein–Nanoparticle Interaction: Corona Formation and Conformational Changes in Proteins on Nanoparticles

(2020) Sung Jean Park   International Journal of Nanomedicine

From Protein Corona to Colloidal Self-Assembly: The Importance of Protein Size in Protein–Nanoparticle Interactions

(2020) Laurent Marichal et al.   LANGMUIR

Membrane Active Peptides Remove Surface Adsorbed Protein Corona From Extracellular Vesicles of Red Blood Cells

(2020) Priyanka Singh et al.   Frontiers in Chemistry

On‐Chip Electrical Monitoring of Real‐Time “Soft” and “Hard” Protein Corona Formation on Carbon Nanoparticles

(2020) Indrajit Srivastava et al.   Small Methods

Quantitative Protein Corona Composition and Dynamics on Carbon Nanotubes in Biological Environments

(2020) Rebecca L Pinals et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Protein interactions and conformations on graphene-based materials mapped using a quartz-crystal microbalance with dissipation monitoring (QCM-D)

(2020) Piramon Hampitak et al.   CARBON

Mapping and identification of soft corona proteins at nanoparticles and their impact on cellular association

(2020) Hossein Mohammad-Beigi et al.   Nature Communications

A high-stringency blueprint of the human proteome

(2020) Subash Adhikari et al.   Nature Communications

In Situ Characterization of Protein Corona Formation on Silica Microparticles Using Confocal Laser Scanning Microscopy Combined with Microfluidics

(2019) Alessia C. G. Weiss et al.   ACS Applied Materials & Interfaces

SERS Probing of Proteins in Gold Nanoparticle Agglomerates

(2019) Gergo Peter Szekeres et al.   Frontiers in Chemistry

Langmuir's Theory of Adsorption: a Centennial Review

(2019) Hans Swenson et al.   LANGMUIR

The Role of Ligands in the Chemical Synthesis and Applications of Inorganic Nanoparticles

(2019) Amelie Heuer-Jungemann et al.   CHEMICAL REVIEWS

Soft and Hard Interactions between Polystyrene Nanoplastics and Human Serum Albumin Protein Corona

(2019) Shinji Kihara et al.   BIOCONJUGATE CHEMISTRY

Possibilities and Limitations of Different Separation Techniques for the Analysis of the Protein Corona

(2019) Claudia Weber et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biopolymer nanoparticle surface chemistry dictates the nature and extent of protein hard corona

(2019) Aalok Basu et al.   JOURNAL OF MOLECULAR LIQUIDS

Formation of a Monolayer Protein Corona around Polystyrene Nanoparticles and Implications for Nanoparticle Agglomeration

(2019) Haixia Wang et al.   Small

Single Particle Plasmonics for Materials Science and Single Particle Catalysis

(2019) Svetlana Alekseeva et al.   ACS Photonics

Protein-Nanoparticle interactions: What are the protein-corona thickness and organization?

(2019) Laurent Marichal et al.   LANGMUIR

The viral protein corona directs viral pathogenesis and amyloid aggregation

(2019) Kariem Ezzat et al.   Nature Communications

Interplay of protein corona and immune cells controls blood residency of liposomes

(2019) Francesca Giulimondi et al.   Nature Communications

Analyzing the Interaction between Two Different Types of Nanoparticles and Serum Albumin

(2019) Roxana E. Cristian et al.   Materials

The formation of a protein corona and the interaction with α-amylase by chitin nanowhiskers in simulated saliva fluid

(2019) Yihui Wang et al.   FOOD HYDROCOLLOIDS

Profiling the Serum Protein Corona of Fibrillar Human Islet Amyloid Polypeptide

(2018) Emily H. Pilkington et al.   ACS Nano

Preservation of the soft protein corona in distinct flow allows identification of weakly bound proteins

(2018) C. Weber et al.   Acta Biomaterialia

Analysis of lipid adsorption on nanoparticles by nanoflow liquid chromatography-tandem mass spectrometry

(2018) Ju Yong Lee et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Influence of dynamic flow conditions on adsorbed plasma protein corona and surface-induced thrombus generation on antifouling brushes

(2018) Kai Yu et al.   BIOMATERIALS

Protein Corona in Response to Flow: Effect on Protein Concentration and Structure

(2018) Dhanya T. Jayaram et al.   BIOPHYSICAL JOURNAL

Structure and Interaction of Nanoparticle–Protein Complexes

(2018) Sugam Kumar et al.   LANGMUIR

Quantitative Comparison of Protein Adsorption and Conformational Changes on Dielectric-Coated Nanoplasmonic Sensing Arrays

(2018) Abdul Ferhan et al.   SENSORS

Binding kinetics of ultrasmall gold nanoparticles with proteins

(2018) André L. Lira et al.   Nanoscale

Adsorption of Human Serum Albumin on Graphene Oxide: Implications for Protein Corona Formation and Conformation

(2018) Xitong Liu et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

The Competitive Dynamic Binding of Some Blood Proteins Adsorbed on Gold Nanoparticles

(2018) Xiaoning Zhang et al.   PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION

Differences among Unique Nanoparticle Protein Corona Constructs: A Case Study Using Data Analytics and Multi-Variant Visualization to Describe Physicochemical Characteristics

(2018) Madison Stewart et al.   Applied Sciences-Basel

On the effect of ligand shell heterogeneity on nanoparticle/protein binding thermodynamics

(2018) Ahmet Bekdemir et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Nanoplasmonic Sensing at the Carbon-Bio Interface: Study of Protein Adsorption at Graphitic and Hydrogenated Carbon Surfaces

(2017) Federico Zen et al.   LANGMUIR

Structure and Interaction in the pH-Dependent Phase Behavior of Nanoparticle–Protein Systems

(2017) Indresh Yadav et al.   LANGMUIR

Evolution and clinical translation of drug delivery nanomaterials

(2017) Shabir Hassan et al.   Nano Today

The timeline of corona formation around silica nanocarriers highlights the role of the protein interactome

(2017) Cédric Pisani et al.   Nanoscale

Probing the binding affinity of plasma proteins adsorbed on Au nanoparticles

(2017) Xiaoning Zhang et al.   Nanoscale

Visualization of the protein corona: towards a biomolecular understanding of nanoparticle-cell-interactions

(2017) Maria Kokkinopoulou et al.   Nanoscale

Concurrent Detection of Protein Adsorption on Mixed Nanoparticles by Differential Centrifugal Sedimentation

(2017) Ruimin Wang et al.   PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION

Super-Resolution Microscopy Unveils Dynamic Heterogeneities in Nanoparticle Protein Corona

(2017) Natalia Feiner-Gracia et al.   Small

The protein corona on nanoparticles as viewed from a nanoparticle-sizing perspective

(2017) Haixia Wang et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

In situ detection of the protein corona in complex environments

(2017) Monica Carril et al.   Nature Communications

Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics

(2017) Nicolas Bertrand et al.   Nature Communications

Modelling and Interpretation of Adsorption Isotherms

(2017) Nimibofa Ayawei et al.   Journal of Chemistry

The nanoparticle protein corona formed in human blood or human blood fractions

(2017) Martin Lundqvist et al.   PLoS One

Understanding the Kinetics of Protein–Nanoparticle Corona Formation

(2016) Oriol Vilanova et al.   ACS Nano

Size-Dependent Protein–Nanoparticle Interactions in Citrate-Stabilized Gold Nanoparticles: The Emergence of the Protein Corona

(2016) Jordi Piella et al.   BIOCONJUGATE CHEMISTRY

Fluorescence labels may significantly affect the protein adsorption on hydrophilic nanomaterials

(2016) Svenja Winzen et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Characterization of the protein corona of gold nanoparticles by an advanced treatment of CE-ICP-MS data

(2016) Magdalena Matczuk et al.   ELECTROPHORESIS

Dissociation coefficients of protein adsorption to nanoparticles as quantitative metrics for description of the protein corona: A comparison of experimental techniques and methodological relevance

(2016) Jonas Hühn et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Understanding Protein Structure Deformation on the Surface of Gold Nanoparticles of Varying Size

(2016) Karen E. Woods et al.   Journal of Physical Chemistry C

Nano–Bio Interactions of Porous and Nonporous Silica Nanoparticles of Varied Surface Chemistry: A Structural, Kinetic, and Thermodynamic Study of Protein Adsorption from RPMI Culture Medium

(2016) Sean E. Lehman et al.   LANGMUIR

The nanoparticle protein corona: The myth of average

(2016) Valérie Forest et al.   Nano Today

The effect of nanoparticle size on in vivo pharmacokinetics and cellular interaction

(2016) Nazanin Hoshyar et al.   Nanomedicine

Protein adsorption induced bridging flocculation: the dominant entropic pathway for nano-bio complexation

(2016) Necla Mine Eren et al.   Nanoscale

Complement proteins bind to nanoparticle protein corona and undergo dynamic exchange in vivo

(2016) Fangfang Chen et al.   Nature Nanotechnology

The Protein Corona of Plant Virus Nanoparticles Influences their Dispersion Properties, Cellular Interactions, and In Vivo Fates

(2016) Andrzej S. Pitek et al.   Small

The Nature of a Hard Protein Corona Forming on Quantum Dots Exposed to Human Blood Serum

(2016) Haixia Wang et al.   Small

A centrifugation-based physicochemical characterization method for the interaction between proteins and nanoparticles

(2016) Ahmet Bekdemir et al.   Nature Communications

In situ characterization of nanoparticle biomolecular interactions in complex biological media by flow cytometry

(2016) Maria Cristina Lo Giudice et al.   Nature Communications

A comprehensive investigation of the differential interaction of human serum albumin with gold nanoparticles based on the variation in morphology and surface functionalization

(2016) Sruthi Ann Alex et al.   RSC Advances

Effect of the protein corona on the colloidal stability and reactivity of LDH-based nanocarriers

(2016) Cecilia Vasti et al.   Journal of Materials Chemistry B

Multi-parametric surface plasmon resonance platform for studying liposome-serum interactions and protein corona formation

(2016) Otto K. Kari et al.   Drug Delivery and Translational Research

Core–Shell Nanoplasmonic Sensing for Characterization of Biocorona Formation and Nanoparticle Surface Interactions

(2016) Rickard Frost et al.   ACS Sensors

Analysis of nanoparticle delivery to tumours

(2016) Stefan Wilhelm et al.   Nature Reviews Materials

Formation Mechanism for Stable Hybrid Clusters of Proteins and Nanoparticles

(2015) Sebastian T. Moerz et al.   ACS Nano

In Vivo Biomolecule Corona around Blood-Circulating, Clinically Used and Antibody-Targeted Lipid Bilayer Nanoscale Vesicles

(2015) Marilena Hadjidemetriou et al.   ACS Nano

Surface Functionalization of Nanoparticles with Polyethylene Glycol: Effects on Protein Adsorption and Cellular Uptake

(2015) Beatriz Pelaz et al.   ACS Nano

Therapeutic Applications of Extracellular Vesicles: Clinical Promise and Open Questions

(2015) Bence György et al.   Annual Review of Pharmacology and Toxicology

Protein Corona of Nanoparticles: Distinct Proteins Regulate the Cellular Uptake

(2015) Sandra Ritz et al.   BIOMACROMOLECULES

The nanoparticle biomolecule corona: lessons learned – challenge accepted?

(2015) D. Docter et al.   CHEMICAL SOCIETY REVIEWS

Protein adsorption onto nanoparticles induces conformational changes: Particle size dependency, kinetics, and mechanisms

(2015) Peter Satzer et al.   ENGINEERING IN LIFE SCIENCES

Kinetics of protein adsorption on gold nanoparticle with variable protein structure and nanoparticle size

(2015) S. Khan et al.   JOURNAL OF CHEMICAL PHYSICS

Flow cytometric analysis of the physical and protein-binding characteristics of solid drug nanoparticle suspensions

(2015) Neill J Liptrott et al.   Nanomedicine

Size and surface chemistry of nanoparticles lead to a variant behavior in the unfolding dynamics of human carbonic anhydrase

(2015) Irem Nasir et al.   Nanoscale

Probing the mechanism of plasma protein adsorption on Au and Ag nanoparticles with FT-IR spectroscopy

(2015) Mengmeng Wang et al.   Nanoscale

Complementary mass spectrometric techniques for the quantification of the protein corona: a case study on gold nanoparticles and human serum proteins

(2015) Nerea Fernández-Iglesias et al.   Nanoscale

Prediction of nanoparticles-cell association based on corona proteins and physicochemical properties

(2015) Rong Liu et al.   Nanoscale

Complementary analysis of the hard and soft protein corona: sample preparation critically effects corona composition

(2015) S. Winzen et al.   Nanoscale

Mapping protein binding sites on the biomolecular corona of nanoparticles

(2015) Philip M. Kelly et al.   Nature Nanotechnology

Component-Specific Analysis of Plasma Protein Corona Formation on Gold Nanoparticles Using Multiplexed Surface Plasmon Resonance

(2015) Abhijeet Patra et al.   Small

Reducing the cytotoxicity of ZnO nanoparticles by a pre-formed protein corona in a supplemented cell culture medium

(2015) Hong Yin et al.   RSC Advances

Virus-Based Nanoparticles as Versatile Nanomachines

(2015) Kristopher J. Koudelka et al.   Annual Review of Virology

Protein Corona Fingerprinting Predicts the Cellular Interaction of Gold and Silver Nanoparticles

(2014) Carl D. Walkey et al.   ACS Nano

The langmuir isotherm: A commonly applied but misleading approach for the analysis of protein adsorption behavior

(2014) Robert A. Latour   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Assessment of PEG on polymeric particles surface, a key step in drug carrier translation

(2014) Jean-Michel Rabanel et al.   JOURNAL OF CONTROLLED RELEASE

Mechanistic aspects of protein corona formation: insulin adsorption onto gold nanoparticle surfaces

(2014) Stefan Grass et al.   JOURNAL OF NANOPARTICLE RESEARCH

Using Hydrogen–Deuterium Exchange to Monitor Protein Structure in the Presence of Gold Nanoparticles

(2014) Ailin Wang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

A Three-Step Model for Protein–Gold Nanoparticle Adsorption

(2014) Ailin Wang et al.   Journal of Physical Chemistry C

Spatial Mapping and Quantification of Soft and Hard Protein Coronas at Silver Nanocubes

(2014) Teodora Miclăuş et al.   NANO LETTERS

Quantitative study of protein coronas on gold nanoparticles with different surface modifications

(2014) Menghua Cui et al.   Nano Research

Small-angle neutron scattering study of differences in phase behavior of silica nanoparticles in the presence of lysozyme and bovine serum albumin proteins

(2014) Indresh Yadav et al.   PHYSICAL REVIEW E

Effects of surface functionalization on the adsorption of human serum albumin onto nanoparticles – a fluorescence correlation spectroscopy study

(2014) Pauline Maffre et al.   Beilstein Journal of Nanotechnology

Temperature: The “Ignored” Factor at the NanoBio Interface

(2013) Morteza Mahmoudi et al.   ACS Nano

Impact of Protein Modification on the Protein Corona on Nanoparticles and Nanoparticle–Cell Interactions

(2013) Lennart Treuel et al.   ACS Nano

Human serum albumin interactions with C60 fullerene studied by spectroscopy, small-angle neutron scattering, and molecular dynamics simulations

(2013) Song Li et al.   JOURNAL OF NANOPARTICLE RESEARCH

Small-Angle Neutron Scattering Study of Structure and Interaction of Nanoparticle, Protein, and Surfactant Complexes

(2013) Sumit Mehan et al.   LANGMUIR

Myoglobin on Silica: A Case Study of the Impact of Adsorption on Protein Structure and Dynamics

(2013) Stéphanie Devineau et al.   LANGMUIR

Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface

(2013) Anna Salvati et al.   Nature Nanotechnology

Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology

(2013) Stefan Tenzer et al.   Nature Nanotechnology

In Vitro Evaluation of Non-Protein Adsorbing Breast Cancer Theranostics Based on19F-Polymer Containing Nanoparticles

(2013) Christian Porsch et al.   PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION

Adsorption of a Protein Monolayer via Hydrophobic Interactions Prevents Nanoparticle Aggregation under Harsh Environmental Conditions

(2013) Sergio Dominguez-Medina et al.   ACS Sustainable Chemistry & Engineering

Protein corona formation around nanoparticles – from the past to the future

(2013) Pablo del Pino et al.   Materials Horizons

Atomic Force Microscopy and Analytical Ultracentrifugation for Probing Nanomaterial Protein Interactions

(2012) Jens Schaefer et al.   ACS Nano

Reversible versus Irreversible Binding of Transferrin to Polystyrene Nanoparticles: Soft and Hard Corona

(2012) Silvia Milani et al.   ACS Nano

Effects of the Presence or Absence of a Protein Corona on Silica Nanoparticle Uptake and Impact on Cells

(2012) Anna Lesniak et al.   ACS Nano

Effects of surface functional groups on the formation of nanoparticle-protein corona

(2012) R. Podila et al.   APPLIED PHYSICS LETTERS

Quantifying the influence of polymer coatings on the serum albumin corona formation around silver and gold nanoparticles

(2012) Lennart Treuel et al.   JOURNAL OF NANOPARTICLE RESEARCH

Interaction of Polyethyleneimine-Functionalized ZnO Nanoparticles with Bovine Serum Albumin

(2012) Soumyananda Chakraborti et al.   LANGMUIR

Physicochemical Characteristics of Protein–NP Bioconjugates: The Role of Particle Curvature and Solution Conditions on Human Serum Albumin Conformation and Fibrillogenesis Inhibition

(2012) Sonia Goy-López et al.   LANGMUIR

Biomolecular coronas provide the biological identity of nanosized materials

(2012) Marco P. Monopoli et al.   Nature Nanotechnology

Protein binding to soft polymeric layers: a quantitative study by fluorescence spectroscopy

(2012) Nicole Welsch et al.   Soft Matter

The Evolution of the Protein Corona around Nanoparticles: A Test Study

(2011) Martin Lundqvist et al.   ACS Nano

Effect of Gold Nanoparticle Aggregation on Cell Uptake and Toxicity

(2011) Alexandre Albanese et al.   ACS Nano

Nanoparticle Size Is a Critical Physicochemical Determinant of the Human Blood Plasma Corona: A Comprehensive Quantitative Proteomic Analysis

(2011) Stefan Tenzer et al.   ACS Nano

Understanding protein adsorption phenomena at solid surfaces

(2011) Michael Rabe et al.   ADVANCES IN COLLOID AND INTERFACE SCIENCE

Understanding and controlling the interaction of nanomaterials with proteins in a physiological environment

(2011) Carl D. Walkey et al.   CHEMICAL SOCIETY REVIEWS

Nanoparticle Size and Surface Chemistry Determine Serum Protein Adsorption and Macrophage Uptake

(2011) Carl D. Walkey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

SANS and UV–vis Spectroscopy Studies of Resultant Structure from Lysozyme Adsorption on Silica Nanoparticles

(2011) Sugam Kumar et al.   LANGMUIR

Evolution of the Protein Corona of Lipid Gene Vectors as a Function of Plasma Concentration

(2011) Giulio Caracciolo et al.   LANGMUIR

Interaction strength between proteins and polyelectrolyte brushes: a small angle X-ray scattering study

(2011) Katja Henzler et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Binding of blood proteins to carbon nanotubes reduces cytotoxicity

(2011) C. Ge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Time Evolution of the Nanoparticle Protein Corona

(2010) Eudald Casals et al.   ACS Nano

The Influence of Surface Composition of Nanoparticles on their Interactions with Serum Albumin

(2010) Lennart Treuel et al.   CHEMPHYSCHEM

Adsorption of β-Lactoglobulin on Spherical Polyelectrolyte Brushes: Direct Proof of Counterion Release by Isothermal Titration Calorimetry

(2010) Katja Henzler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

What the Cell “Sees” in Bionanoscience

(2010) Dorota Walczyk et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Interaction of Gold Nanoparticles with Common Human Blood Proteins

(2009) Silvia H. De Paoli Lacerda et al.   ACS Nano

Analysis of the Dynamics of Assembly and Structural Impact for a Histidine Tagged FGF1−1.5 nm Au Nanoparticle Bioconjugate

(2009) Joshua M. Kogot et al.   BIOCONJUGATE CHEMISTRY

Repeatability and Reproducibility in Proteomic Identifications by Liquid Chromatography−Tandem Mass Spectrometry

(2009) David L. Tabb et al.   JOURNAL OF PROTEOME RESEARCH

Quantitative analysis of the protein corona on FePt nanoparticles formed by transferrin binding

(2009) X. Jiang et al.   Journal of the Royal Society Interface

A quantitative fluorescence study of protein monolayer formation on colloidal nanoparticles

(2009) Carlheinz Röcker et al.   Nature Nanotechnology

Interaction of gold nanoparticles with protein: A spectroscopic study to monitor protein conformational changes

(2008) Nishima Wangoo et al.   APPLIED PHYSICS LETTERS

Inhibition of Amyloid β Protein Fibrillation by Polymeric Nanoparticles

(2008) Celia Cabaleiro-Lago et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Directed Motion of Proteins along Tethered Polyelectrolytes

(2008) Katja Henzler et al.   PHYSICAL REVIEW LETTERS

Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts

(2008) M. Lundqvist et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA