Attenuation of NLRP3 Inflammasome Activation by Indirubin-Derived PROTAC Targeting HDAC6

Indirubin Derivatives as Dual Inhibitors Targeting Cyclin-Dependent Kinase and Histone Deacetylase for Treating Cancer

(2021) Zhuoxian Cao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery

(2020) George M. Burslem et al.   CELL

A review of traditional uses, phytochemistry and pharmacology of the genus Indigofera

(2020) Elise Gerometta et al.   JOURNAL OF ETHNOPHARMACOLOGY

Development of Selective Histone Deacetylase 6 (HDAC6) Degraders Recruiting Von Hippel–Lindau (VHL) E3 Ubiquitin Ligase

(2020) Ka Yang et al.   ACS Medicinal Chemistry Letters

HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation

(2020) Venkat Giri Magupalli et al.   SCIENCE

Recent advances in small molecule PROTACs for the treatment of cancer

(2020) Wen Li et al.   CURRENT MEDICINAL CHEMISTRY

Proteolysis targeting chimera (PROTAC) in drug discovery paradigm: Recent progress and future challenges

(2020) Shenxin Zeng et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

HDAC6 as privileged target in drug discovery: A perspective

(2020) Sravani Pulya et al.   PHARMACOLOGICAL RESEARCH

Targeted inhibition of histone deacetylase6 in inflammatory diseases

(2019) Jie Ran et al.   Thoracic Cancer

Developing potent PROTACs tools for selective degradation of HDAC6 protein

(2019) Zixuan An et al.   Protein & Cell

High-selective HDAC6 inhibitor promotes HDAC6 degradation following autophagy modulation and enhanced antitumor immunity in glioblastoma

(2019) Jia-Rong Liu et al.   BIOCHEMICAL PHARMACOLOGY

Development of Multifunctional Histone Deacetylase 6 Degraders with Potent Antimyeloma Activity

(2019) Hao Wu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Old but Gold: Tracking the New Guise of Histone Deacetylase 6 (HDAC6) Enzyme as a Biomarker and Therapeutic Target in Rare Diseases

(2019) Margherita Brindisi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of targeted protein degradation therapeutics

(2019) Philip P. Chamberlain et al.   Nature Chemical Biology

Discovery of Second-Generation NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization

(2019) Yuqi Jiang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of the first small molecule histone deacetylase 6 (HDAC6) degraders

(2018) Ka Yang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Recent advances in the discovery of potent and selective HDAC6 inhibitors

(2018) Xiu-Xiu Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Identification and Structure–Activity Relationship of HDAC6 Zinc-Finger Ubiquitin Binding Domain Inhibitors

(2018) Renato Ferreira de Freitas et al.   JOURNAL OF MEDICINAL CHEMISTRY

HDAC6 at Crossroads of Infection and Innate Immunity

(2018) Olga Moreno-Gonzalo et al.   TRENDS IN IMMUNOLOGY

Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals)

(2017) Matthias Schiedel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Histone deacetylase 6 structure and molecular basis of catalysis and inhibition

(2016) Yang Hai et al.   Nature Chemical Biology

Structural insights into HDAC6 tubulin deacetylation and its selective inhibition

(2016) Yasuyuki Miyake et al.   Nature Chemical Biology

Induced protein degradation: an emerging drug discovery paradigm

(2016) Ashton C. Lai et al.   NATURE REVIEWS DRUG DISCOVERY

Interplay Between HDAC6 and Its Interacting Partners: Essential Roles in the Aggresome-Autophagy Pathway and Neurodegenerative Diseases

(2014) Jin Yan   DNA AND CELL BIOLOGY

Influenza A virus uses the aggresome processing machinery for host cell entry

(2014) Indranil Banerjee et al.   SCIENCE

Proteomic identification and functional characterization of MYH9, Hsc70, and DNAJA1 as novel substrates of HDAC6 deacetylase activity

(2014) Linlin Zhang et al.   Protein & Cell

3,4-Methylenedioxy-β-nitrostyrene Inhibits NLRP3 Inflammasome Activation by Blocking Assembly of the Inflammasome

(2013) Yuan He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Comprehensive Mathematical Model for Three-Body Binding Equilibria

(2013) Eugene F. Douglass et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?

(2013) Claudia Simões-Pires et al.   Molecular Neurodegeneration

Identification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis

(2012) E Kerr et al.   CELL DEATH AND DIFFERENTIATION

Histone deacetylase 6 plays a role as a distinct regulator of diverse cellular processes

(2012) Yingxiu Li et al.   FEBS Journal

Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin

(2011) David Kaluza et al.   EMBO JOURNAL