Natural Small Molecules Enabled Efficient Immunotherapy through Supramolecular Self-Assembly in P53-Mutated Colorectal Cancer

A selective p53 activator and anticancer agent to improve colorectal cancer therapy

(2021) Helena Ramos et al.   Cell Reports

CD4 T-Cell Exhaustion: Does It Exist and What Are Its Roles in Cancer?

(2021) Alexandra M. Miggelbrink et al.   CLINICAL CANCER RESEARCH

Tumor microenvironment-activated self-recognizing nanodrug through directly tailored assembly of small-molecules for targeted synergistic chemotherapy

(2020) Yang Li et al.   JOURNAL OF CONTROLLED RELEASE

Synthesis and evaluation of new compounds bearing 3-(4-aminopiperidin-1-yl)methyl magnolol scaffold as anticancer agents for the treatment of non-small cell lung cancer via targeting autophagy

(2020) Min Zhao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

cGAS in action: Expanding roles in immunity and inflammation

(2019) Andrea Ablasser et al.   SCIENCE

Tumor Microenvironment Responsive Drug‐Dye‐Peptide Nanoassembly for Enhanced Tumor‐Targeting, Penetration, and Photo‐Chemo‐Immunotherapy

(2019) Jinrong Peng et al.   ADVANCED FUNCTIONAL MATERIALS

Inflammatory signaling in genomically instable cancers

(2019) Francien Talens et al.   CELL CYCLE

Self-Assemblies Based on Traditional Medicine Berberine and Cinnamic Acid for Adhesion-Induced Inhibition Multidrug-Resistant Staphylococcus aureus

(2019) Xuemei Huang et al.   ACS Applied Materials & Interfaces

TLR-3 Stimulation Skews M2 Macrophages to M1 Through IFN-αβ Signaling and Restricts Tumor Progression

(2018) Aurobind Vidyarthi et al.   Frontiers in Immunology

Improving anticancer activity towards colon cancer cells with a new p53-activating agent

(2018) Liliana Raimundo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods

(2018) J. Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

DIMP53-1: a novel small-molecule dual inhibitor of p53-MDM2/X interactions with multifunctional p53-dependent anticancer properties

(2017) Joana Soares et al.   Molecular Oncology

Proteomic identification of ERP29 as a key chemoresistant factor activated by the aggregating p53 mutant Arg282Trp

(2017) Y Zhang et al.   ONCOGENE

Signalling strength determines proapoptotic functions of STING

(2017) Muhammet F. Gulen et al.   Nature Communications

Clinical Overview of MDM2/X-Targeted Therapies

(2016) Andrew Burgess et al.   Frontiers in Oncology

Nanodrug Formed by Coassembly of Dual Anticancer Drugs to Inhibit Cancer Cell Drug Resistance

(2015) Yuanyuan Zhao et al.   ACS Applied Materials & Interfaces

Encapsulation of honokiol into self-assembled pectin nanoparticles for drug delivery to HepG2 cells

(2015) Yuxia Zhang et al.   CARBOHYDRATE POLYMERS

Enhanced-oxidation and electrochemical determination of honokiol and magnolol using NMP-exfoliated graphene nanosheets

(2015) Dong Sun et al.   JOURNAL OF MOLECULAR LIQUIDS

Sirolimus-loaded polymeric micelles with honokiol for oral delivery

(2015) Xinru Li et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

IMPACT OF LEFT VENTRICULAR OUTFLOW TRACT OBSTRUCTION AND MICROCIRCULATORY DYSFUNCTION ON CORONARY HAEMODYNAMICS IN HYPERTROPHIC CARDIOMYOPATHY

(2015) Claire E. Raphael et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A tryptophanol-derived oxazolopiperidone lactam is cytotoxic against tumors via inhibition of p53 interaction with murine double minute proteins

(2015) Joana Soares et al.   PHARMACOLOGICAL RESEARCH

Indocyanine Green

(2015) Michaela B. Reinhart et al.   Surgical Innovation

Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3

(2015) Vinodkumar B. Pillai et al.   Nature Communications

Honokiol nanosuspensions: Preparation, increased oral bioavailability and dramatically enhanced biodistribution in the cardio-cerebro-vascular system

(2014) Meihua Han et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Trp53 Inactivation in the Tumor Microenvironment Promotes Tumor Progression by Expanding the Immunosuppressive Lymphoid-like Stromal Network

(2013) G. Guo et al.   CANCER RESEARCH

Interactions between the tumor suppressor p53 and immune responses

(2012) Daniel Menendez et al.   CURRENT OPINION IN ONCOLOGY

STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway

(2012) Y. Tanaka et al.   Science Signaling

Translational approaches targeting the p53 pathway for anti-cancer therapy

(2011) Frank Essmann et al.   BRITISH JOURNAL OF PHARMACOLOGY

Trp53 negatively regulates autoimmunity via the STAT3-Th17 axis

(2011) Shuzhong Zhang et al.   FASEB JOURNAL

Viral apoptosis is induced by IRF-3-mediated activation of Bax

(2010) Saurabh Chattopadhyay et al.   EMBO JOURNAL

Honokiol Nanoparticles in Thermosensitive Hydrogel: Therapeutic Effects on Malignant Pleural Effusion

(2009) Fang Fang et al.   ACS Nano

Poly(ɛ-caprolactone)–poly(ethylene glycol)–poly(ɛ-caprolactone) (PCL–PEG–PCL) nanoparticles for honokiol delivery in vitro

(2009) MaLing Gou et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Preparation of MPEG–PLA nanoparticle for honokiol delivery in vitro

(2009) XiuLing Zheng et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

Multifunctional Uniform Nanoparticles Composed of a Magnetite Nanocrystal Core and a Mesoporous Silica Shell for Magnetic Resonance and Fluorescence Imaging and for Drug Delivery

(2008) Jaeyun Kim et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nanoparticle therapeutics: an emerging treatment modality for cancer

(2008) Mark E. Davis et al.   NATURE REVIEWS DRUG DISCOVERY