Effects of ACE2 deficiency on physical performance and physiological adaptations of cardiac and skeletal muscle to exercise

Downregulation of the Vascular Renin-Angiotensin System by Aerobic Training　– Focus on the Balance Between Vasoconstrictor and Vasodilator Axes –

(2015) Sebastião D. Silva Jr. et al.   CIRCULATION JOURNAL

Angiotensin II Induces Skeletal Muscle Atrophy by Activating TFEB-MediatedMuRF1ExpressionNovelty and Significance

(2015) Philipp Du Bois et al.   CIRCULATION RESEARCH

Angiotensin II can directly induce mitochondrial dysfunction, decrease oxidative fibre number and induce atrophy in mouse hindlimb skeletal muscle

(2015) Tomoyasu Kadoguchi et al.   EXPERIMENTAL PHYSIOLOGY

The aromatic amino acid tryptophan stimulates skeletal muscle IGF1/p70s6k/mTor signaling in vivo and the expression of myogenic genes in vitro

(2015) Amy Dukes et al.   NUTRITION

Expression of the Mas receptor is upregulated in skeletal muscle wasting

(2014) María Gabriela Morales et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Left atrial volume index is an independent predictor of hypertensive response to exercise in patients with hypertension

(2014) Sang-Eun Lee et al.   HYPERTENSION RESEARCH

Role of angiotensin-converting enzyme 2/angiotensin-(1–7)/Mas axis in the hypotensive effect of azilsartan

(2014) Jun Iwanami et al.   HYPERTENSION RESEARCH

Effects of exercise training on systo–diastolic ventricular dysfunction in patients with hypertension: an echocardiographic study with tissue velocity and strain imaging evaluation

(2014) Massimo Leggio et al.   HYPERTENSION RESEARCH

Wnt Protein-mediated Satellite Cell Conversion in Adult and Aged Mice Following Voluntary Wheel Running

(2014) Shin Fujimaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ACE2 Is Augmented in Dystrophic Skeletal Muscle and Plays a Role in Decreasing Associated Fibrosis

(2014) Cecilia Riquelme et al.   PLoS One

Autonomic, locomotor and cardiac abnormalities in a mouse model of muscular dystrophy: targeting the renin-angiotensin system

(2013) Rasna Sabharwal et al.   EXPERIMENTAL PHYSIOLOGY

Restoration of muscle strength in dystrophic muscle by angiotensin-1-7 through inhibition of TGF-β signalling

(2013) María José Acuña et al.   HUMAN MOLECULAR GENETICS

Signaling effectors underlying pathologic growth and remodeling of the heart

(2013) Jop H. van Berlo et al.   JOURNAL OF CLINICAL INVESTIGATION

An orally active angiotensin-(1–7) inclusion compound and exercise training produce similar cardiovascular effects in spontaneously hypertensive rats

(2013) Mariane Bertagnolli et al.   PEPTIDES

Voluntary running in mice beneficially modulates myocardial ischemic tolerance, signaling kinases, and gene expression patterns

(2012) Boris P. Budiono et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Similar skeletal muscle angiogenic and mitochondrial signalling following 8 weeks of endurance exercise in mice: discontinuousversuscontinuous training

(2012) Moh H. Malek et al.   EXPERIMENTAL PHYSIOLOGY

Angiotensin converting enzyme 2 abrogates bleomycin-induced lung injury

(2012) G. J. Rey-Parra et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation

(2012) Tatsuo Hashimoto et al.   NATURE

Exercise induces renin–angiotensin system unbalance and high collagen expression in the heart of Mas-deficient mice

(2012) Gislaine G. Guimarães et al.   PEPTIDES

Beneficial Effects of Long-Term Administration of an Oral Formulation of Angiotensin-(1–7) in Infarcted Rats

(2012) Fúlvia D. Marques et al.   International Journal of Hypertension

An orally active formulation of angiotensin-(1-7) produces an antithrombotic effect

(2011) Rodrigo Araujo Fraga-Silva et al.   Clinics

Angiotensin-Converting Enzyme 2 Deficiency Is Associated With Impaired Gestational Weight Gain and Fetal Growth Restriction

(2011) Manish S. Bharadwaj et al.   HYPERTENSION

Exercise training normalizes ACE and ACE2 in the brain of rabbits with pacing-induced heart failure

(2010) Sumit Kar et al.   JOURNAL OF APPLIED PHYSIOLOGY

The biological control of voluntary exercise, spontaneous physical activity and daily energy expenditure in relation to obesity: human and rodent perspectives

(2010) T. Garland et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Targeting the ACE2–Ang-(1–7) pathway in cardiac fibroblasts to treat cardiac remodeling and heart failure

(2010) Michikado Iwata et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Loss of Angiotensin-Converting Enzyme 2 Accelerates Maladaptive Left Ventricular Remodeling in Response to Myocardial Infarction

(2009) Zamaneh Kassiri et al.   Circulation-Heart Failure

Exercise training in heart failure: reduction in angiotensin II, sympathetic nerve activity, and baroreflex control

(2008) Carlos E. Negrão et al.   JOURNAL OF APPLIED PHYSIOLOGY

Genetically altered animal models for Mas and angiotensin-(1-7)

(2007) Natalia Alenina et al.   EXPERIMENTAL PHYSIOLOGY