Personalized radiotherapy: concepts, biomarkers and trial design

Tumor phosphatidylinositol 3-kinase signaling in therapy resistance and metastatic dissemination of rectal cancer: Opportunities for signaling-adapted therapies

(2015) Anne Hansen Ree et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

PET imaging biomarkers in head and neck cancer

(2015) Sarah Differding et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Detection of Clinically Significant Prostate Cancer Using Magnetic Resonance Imaging–Ultrasound Fusion Targeted Biopsy: A Systematic Review

(2015) Massimo Valerio et al.   EUROPEAN UROLOGY

The tumour hypoxia marker pimonidazole reflects a transcriptional programme associated with aggressive prostate cancer

(2014) H B Ragnum et al.   BRITISH JOURNAL OF CANCER

Improved Recurrence-Free Survival with ARCON for Anemic Patients with Laryngeal Cancer

(2014) Geert O. Janssens et al.   CLINICAL CANCER RESEARCH

The REQUITE Project: Validating Predictive Models and Biomarkers of Radiotherapy Toxicity to Reduce Side-effects and Improve Quality of Life in Cancer Survivors

(2014) C. West et al.   CLINICAL ONCOLOGY

De-escalation treatment protocols for human papillomavirus-associated oropharyngeal squamous cell carcinoma: A systematic review and meta-analysis of current clinical trials

(2014) Liam Masterson et al.   EUROPEAN JOURNAL OF CANCER

Using physiologically-based pharmacokinetic-guided “body-on-a-chip” systems to predict mammalian response to drug and chemical exposure

(2014) Jong Hwan Sung et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

In vivozebrafish assays for analyzing drug toxicity

(2014) Demetrio Raldúa et al.   Expert Opinion on Drug Metabolism & Toxicology

Biomarkers of Treatment Toxicity in Combined-Modality Cancer Therapies with Radiation and Systemic Drugs: Study Design, Multiplex Methods, Molecular Networks

(2014) Anne Ree et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Global Harmonization of Quality Assurance Naming Conventions in Radiation Therapy Clinical Trials

(2014) Christos Melidis et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Interaction of Radiation Therapy With Molecular Targeted Agents

(2014) Zachary S. Morris et al.   JOURNAL OF CLINICAL ONCOLOGY

Enhancing the Efficacy of Radiation Therapy: Premises, Promises, and Practicality

(2014) C. Norman Coleman et al.   JOURNAL OF CLINICAL ONCOLOGY

Molecular Radiobiology: The State of the Art

(2014) Amato J. Giaccia   JOURNAL OF CLINICAL ONCOLOGY

Milestones in the Use of Combined-Modality Radiation Therapy and Chemotherapy

(2014) Theodore S. Lawrence et al.   JOURNAL OF CLINICAL ONCOLOGY

Randomized Phase III Trial of Concurrent Accelerated Radiation Plus Cisplatin With or Without Cetuximab for Stage III to IV Head and Neck Carcinoma: RTOG 0522

(2014) K. Kian Ang et al.   JOURNAL OF CLINICAL ONCOLOGY

Molecular Imaging Biomarkers for Oncology Clinical Trials

(2014) D. A. Mankoff et al.   JOURNAL OF NUCLEAR MEDICINE

Fluorouracil-based adjuvant chemotherapy after preoperative chemoradiotherapy in rectal cancer: long-term results of the EORTC 22921 randomised study

(2014) Jean-François Bosset et al.   LANCET ONCOLOGY

Tumour genomic and microenvironmental heterogeneity for integrated prediction of 5-year biochemical recurrence of prostate cancer: a retrospective cohort study

(2014) Emilie Lalonde et al.   LANCET ONCOLOGY

A three-stage genome-wide association study identifies a susceptibility locus for late radiotherapy toxicity at 2q24.1

(2014) Laura Fachal et al.   NATURE GENETICS

Biomarkers of Histone Deacetylase Inhibitor Activity in a Phase 1 Combined-Modality Study with Radiotherapy

(2014) Anne Hansen Ree et al.   PLoS One

Dynamics of tumor hypoxia assessed by 18F-FAZA PET/CT in head and neck and lung cancer patients during chemoradiation: Possible implications for radiotherapy treatment planning strategies

(2014) Vikram R. Bollineni et al.   RADIOTHERAPY AND ONCOLOGY

A prospective study comparing the predictions of doctors versus models for treatment outcome of lung cancer patients: A step toward individualized care and shared decision making

(2014) Cary Oberije et al.   RADIOTHERAPY AND ONCOLOGY

An umbrella protocol for standardized data collection (SDC) in rectal cancer: A prospective uniform naming and procedure convention to support personalized medicine

(2014) Elisa Meldolesi et al.   RADIOTHERAPY AND ONCOLOGY

Nomogram predicting response after chemoradiotherapy in rectal cancer using sequential PETCT imaging: A multicentric prospective study with external validation

(2014) Ruud G.P.M. van Stiphout et al.   RADIOTHERAPY AND ONCOLOGY

Rapid learning in practice: A lung cancer survival decision support system in routine patient care data

(2014) Andre Dekker et al.   RADIOTHERAPY AND ONCOLOGY

Improving the Efficacy of Chemoradiation with Targeted Agents

(2014) M. A. Morgan et al.   Cancer Discovery

Matrix metalloproteinases and gut toxicity following cytotoxic cancer therapy

(2014) Noor Al-Dasooqi   Current Opinion in Supportive and Palliative Care

Serum Biomarkers for the Detection of Cardiac Toxicity after Chemotherapy and Radiation Therapy in Breast Cancer Patients

(2014) Sibo Tian et al.   Frontiers in Oncology

Strategic Applications of Gene Expression: From Drug Discovery/Development to Bedside

(2013) Jane P. F. Bai et al.   AAPS Journal

miR-210 is a target of hypoxia-inducible factors 1 and 2 in renal cancer, regulates ISCU and correlates with good prognosis

(2013) R I McCormick et al.   BRITISH JOURNAL OF CANCER

Standards of Reporting for MRI-targeted Biopsy Studies (START) of the Prostate: Recommendations from an International Working Group

(2013) Caroline M. Moore et al.   EUROPEAN UROLOGY

Molecular targets and mechanisms of radiosensitization using DNA damage response pathways

(2013) David R Raleigh et al.   Future Oncology

Does Quality of Radiation Therapy Predict Outcomes of Multicenter Cooperative Group Trials? A Literature Review

(2013) Alysa Fairchild et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Interactive Decision-Support Tool for Risk-Based Radiation Therapy Plan Comparison for Hodgkin Lymphoma

(2013) N. Patrik Brodin et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Use of pharmacogenetics for predicting cancer prognosis and treatment exposure, response and toxicity

(2013) Daniel L Hertz et al.   JOURNAL OF HUMAN GENETICS

Opportunities and Challenges in the Era of Molecularly Targeted Agents and Radiation Therapy

(2013) Steven H. Lin et al.   JNCI-Journal of the National Cancer Institute

Combining Radiotherapy and Cancer Immunotherapy: A Paradigm Shift

(2013) Silvia C. Formenti et al.   JNCI-Journal of the National Cancer Institute

Metcalfe's law and the biology information commons

(2013) Stephen H Friend et al.   NATURE BIOTECHNOLOGY

Tumor stroma: a complexity dictated by the hypoxic tumor microenvironment

(2013) A Casazza et al.   ONCOGENE

‘Rapid Learning health care in oncology’ – An approach towards decision support systems enabling customised radiotherapy’

(2013) Philippe Lambin et al.   RADIOTHERAPY AND ONCOLOGY

Design and conduct of early-phase radiotherapy trials with targeted therapeutics: Lessons from the PRAVO experience

(2013) Anne Hansen Ree et al.   RADIOTHERAPY AND ONCOLOGY

Selection of patients for radiotherapy with protons aiming at reduction of side effects: The model-based approach

(2013) Johannes A. Langendijk et al.   RADIOTHERAPY AND ONCOLOGY

Emerging evidence on the pathobiology of mucositis

(2013) Noor Al-Dasooqi et al.   SUPPORTIVE CARE IN CANCER

Target detection: Magnetic resonance imaging-ultrasound fusion–guided prostate biopsy

(2013) Geoffrey A. Sonn et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Incorporating prognostic imaging biomarkers into clinical practice

(2013) W. Phillip Law et al.   CANCER IMAGING

The National Institutes of Health Microphysiological Systems Program focuses on a critical challenge in the drug discovery pipeline

(2013) Margaret L Sutherland et al.   Stem Cell Research & Therapy

Microphysiological systems and low-cost microfluidic platform with analytics

(2013) Alec ST Smith et al.   Stem Cell Research & Therapy

Repeated Autologous Bone Marrow-Derived Mesenchymal Stem Cell Injections Improve Radiation-Induced Proctitis in Pigs

(2013) Christine Linard et al.   Stem Cells Translational Medicine

Normal tissues toxicities triggered by combined anti-angiogenic and radiation therapies: hurdles might be ahead

(2012) M Mangoni et al.   BRITISH JOURNAL OF CANCER

Hypoxia-Induced Gene Expression in Chemoradioresistant Cervical Cancer Revealed by Dynamic Contrast-Enhanced MRI

(2012) C. Halle et al.   CANCER RESEARCH

Tumour response prediction by diffusion-weighted MR imaging: Ready for clinical use?

(2012) Linda Heijmen et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Quantifying heterogeneity in human tumours using MRI and PET

(2012) Marie-Claude Asselin et al.   EUROPEAN JOURNAL OF CANCER

Qualification of imaging biomarkers for oncology drug development

(2012) John C. Waterton et al.   EUROPEAN JOURNAL OF CANCER

Radiomics: Extracting more information from medical images using advanced feature analysis

(2012) Philippe Lambin et al.   EUROPEAN JOURNAL OF CANCER

How many molecular subtypes? Implications of the unique tumor principle in personalized medicine

(2012) Shuji Ogino et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Clinical Outcome of the ACCORD 12/0405 PRODIGE 2 Randomized Trial in Rectal Cancer

(2012) Jean-Pierre Gérard et al.   JOURNAL OF CLINICAL ONCOLOGY

Radiomics: the process and the challenges

(2012) Virendra Kumar et al.   MAGNETIC RESONANCE IMAGING

Individualization of cancer treatment from radiotherapy perspective

(2012) Ala Yaromina et al.   Molecular Oncology

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

(2012) Christina Curtis et al.   NATURE

Predicting outcomes in radiation oncology—multifactorial decision support systems

(2012) Philippe Lambin et al.   Nature Reviews Clinical Oncology

Preclinical models in radiation oncology

(2012) Jenna Kahn et al.   Radiation Oncology

Exploratory prospective trial of hypoxia-specific PET imaging during radiochemotherapy in patients with locally advanced head-and-neck cancer

(2012) Daniel Zips et al.   RADIOTHERAPY AND ONCOLOGY

Guidelines for preclinical and early phase clinical assessment of novel radiosensitisers

(2011) K J Harrington et al.   BRITISH JOURNAL OF CANCER

Development of a Hypoxia Gene Expression Classifier with Predictive Impact for Hypoxic Modification of Radiotherapy in Head and Neck Cancer

(2011) K. Toustrup et al.   CANCER RESEARCH

DNA Repair Biomarker Profiling of Head and Neck Cancer: Ku80 Expression Predicts Locoregional Failure and Death following Radiotherapy

(2011) B. J. Moeller et al.   CLINICAL CANCER RESEARCH

Optimizing targeted cancer therapy: Towards clinical application of systems biology approaches

(2011) Arend H. Sikkema et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Exploratory Study of the Prognostic Value of Microenvironmental Parameters During Fractionated Irradiation in Human Squamous Cell Carcinoma Xenografts

(2011) Ala Yaromina et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Nomograms for Predicting Local Recurrence, Distant Metastases, and Overall Survival for Patients With Locally Advanced Rectal Cancer on the Basis of European Randomized Clinical Trials

(2011) Vincenzo Valentini et al.   JOURNAL OF CLINICAL ONCOLOGY

Delivering affordable cancer care in high-income countries

(2011) Richard Sullivan et al.   LANCET ONCOLOGY

Targeted therapies: how personal should we go?

(2011) Miriam Martini et al.   Nature Reviews Clinical Oncology

The current landscape of locally advanced rectal cancer

(2011) Mebea Aklilu et al.   Nature Reviews Clinical Oncology

Methodological and practical challenges for personalized cancer therapies

(2011) Ignacio I. Wistuba et al.   Nature Reviews Clinical Oncology

Gastrointestinal toxicity of vorinostat: reanalysis of phase 1 study results with emphasis on dose-volume effects of pelvic radiotherapy

(2011) Åse Bratland et al.   Radiation Oncology

Residual DNA double strand breaks in perfused but not in unperfused areas determine different radiosensitivity of tumours

(2011) Apostolos Menegakis et al.   RADIOTHERAPY AND ONCOLOGY

Is it time for tailored treatment of rectal cancer? From prescribing by consensus to prescribing by numbers

(2011) Vincenzo Valentini et al.   RADIOTHERAPY AND ONCOLOGY

Gene expression classifier predicts for hypoxic modification of radiotherapy with nimorazole in squamous cell carcinomas of the head and neck

(2011) Kasper Toustrup et al.   RADIOTHERAPY AND ONCOLOGY

Strategies for kinome profiling in cancer and potential clinical applications: chemical proteomics and array-based methods

(2010) Sander R. Piersma et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Molecular imaging and targeted therapies

(2010) David L. Morse et al.   BIOCHEMICAL PHARMACOLOGY

Large meta-analysis of multiple cancers reveals a common, compact and highly prognostic hypoxia metagene

(2010) F M Buffa et al.   BRITISH JOURNAL OF CANCER

hsa-miR-210 is a marker of tumor hypoxia and a prognostic factor in head and neck cancer

(2010) Harriet E. Gee et al.   CANCER

Magnetic Resonance Metabolomics of Intact Tissue: A Biotechnological Tool in Cancer Diagnostics and Treatment Evaluation

(2010) T. F. Bathen et al.   CANCER RESEARCH

The biology underlying molecular imaging in oncology: from genome to anatome and back again

(2010) R.J. Gillies et al.   CLINICAL RADIOLOGY

Predictive biomarkers for personalised anti-cancer drug use: Discovery to clinical implementation

(2010) Nayef A. Alymani et al.   EUROPEAN JOURNAL OF CANCER

Radiation Dose–Volume Effects in the Stomach and Small Bowel

(2010) Brian D. Kavanagh et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Prediction of Response to Preoperative Chemoradiotherapy in Rectal Cancer by Multiplex Kinase Activity Profiling

(2010) Sigurd Folkvord et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

The Lessons of QUANTEC: Recommendations for Reporting and Gathering Data on Dose–Volume Dependencies of Treatment Outcome

(2010) Andrew Jackson et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Tirapazamine, Cisplatin, and Radiation Versus Cisplatin and Radiation for Advanced Squamous Cell Carcinoma of the Head and Neck (TROG 02.02, HeadSTART): A Phase III Trial of the Trans-Tasman Radiation Oncology Group

(2010) Danny Rischin et al.   JOURNAL OF CLINICAL ONCOLOGY

Rapid-Learning System for Cancer Care

(2010) Amy P. Abernethy et al.   JOURNAL OF CLINICAL ONCOLOGY

Vorinostat, a histone deacetylase inhibitor, combined with pelvic palliative radiotherapy for gastrointestinal carcinoma: the Pelvic Radiation and Vorinostat (PRAVO) phase 1 study

(2010) Anne Hansen Ree et al.   LANCET ONCOLOGY

Use of new imaging techniques to predict tumour response to therapy

(2010) Vanessa N Harry et al.   LANCET ONCOLOGY

Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of individual patient data

(2010) Monique Maas et al.   LANCET ONCOLOGY

Personalized therapies in the cancer "omics" era

(2010) Alberto Ocana et al.   Molecular Cancer

Imaging in Radiation Oncology: A Perspective

(2010) L. A. Dawson et al.   ONCOLOGIST

Single Nucleotide Polymorphisms of DNA Repair Genes as Predictors of Radioresponse

(2010) Matthew B. Parliament et al.   SEMINARS IN RADIATION ONCOLOGY

Poly(ADP-Ribose) Polymerase Inhibition as a Model for Synthetic Lethality in Developing Radiation Oncology Targets

(2010) Anthony J. Chalmers et al.   SEMINARS IN RADIATION ONCOLOGY

Pre-radiotherapy plasma carotenoids and markers of oxidative stress are associated with survival in head and neck squamous cell carcinoma patients: a prospective study

(2009) Amrit K Sakhi et al.   BMC CANCER

The impact of radiotherapy late effects on quality of life in gynaecological cancer patients

(2009) C L Barker et al.   BRITISH JOURNAL OF CANCER

Involvement of Mitochondrial DNA Sequence Variations and Respiratory Activity in Late Complications following Radiotherapy

(2009) G. A. Alsbeih et al.   CLINICAL CANCER RESEARCH

Acute Normal Tissue Reactions in Head-and-Neck Cancer Patients Treated With IMRT: Influence of Dose and Association With Genetic Polymorphisms in DNA DSB Repair Genes

(2009) Joke Werbrouck et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Histone Deacetylase Inhibitors in Cancer Therapy

(2009) Andrew A. Lane et al.   JOURNAL OF CLINICAL ONCOLOGY

Dose Escalation Methods in Phase I Cancer Clinical Trials

(2009) Christophe Le Tourneau et al.   JNCI-Journal of the National Cancer Institute

The cancer genome

(2009) Michael R. Stratton et al.   NATURE

Endogenous and radiation-induced expression of γH2AX in biopsies from patients treated for carcinoma of the uterine cervix

(2009) Peggy L. Olive et al.   RADIOTHERAPY AND ONCOLOGY

Single Nucleotide Polymorphisms, Apoptosis, and the Development of Severe Late Adverse Effects After Radiotherapy

(2008) D. Azria et al.   CLINICAL CANCER RESEARCH

hsa-miR-210 Is Induced by Hypoxia and Is an Independent Prognostic Factor in Breast Cancer

(2008) C. Camps et al.   CLINICAL CANCER RESEARCH

Quantitative imaging biomarkers in the clinical development of targeted therapeutics: current and future perspectives

(2008) James PB O'Connor et al.   LANCET ONCOLOGY

Evidence and research in rectal cancer

(2008) Vincenzo Valentini et al.   RADIOTHERAPY AND ONCOLOGY