Oocyte–somatic cell interactions in the human ovary—novel role of bone morphogenetic proteins and growth differentiation factors

BMPs in bone regeneration: Less is more effective, a paradigm-shift

(2016) Katharina Schmidt-Bleek et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Effects of growth differentiation factor 8 on steroidogenesis in human granulosa-lutein cells

(2016) Hsun-Ming Chang et al.   FERTILITY AND STERILITY

Connective tissue growth factor mediates growth differentiation factor 8-induced increase of lysyl oxidase activity in human granulosa-lutein cells

(2016) Hsun-Ming Chang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Growth differentiation factor 8 suppresses cell proliferation by up-regulating CTGF expression in human granulosa cells

(2016) Hsun-Ming Chang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Differential activation of noncanonical SMAD2/SMAD3 signaling by bone morphogenetic proteins causes disproportionate induction of hyaluronan production in immortalized human granulosa cells

(2016) Han Zhang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Dysregulation of granulosal bone morphogenetic protein receptor 1B density is associated with reduced ovarian reserve and the age-related decline in human fertility

(2016) Sheena L.P. Regan et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Serum GDF-8 levels change dynamically during controlled ovarian hyperstimulation in patients undergoing IVF/ICSI-ET

(2016) Lanlan Fang et al.   Scientific Reports

Transcriptomic Diversification of Developing Cumulus and Mural Granulosa Cells in Mouse Ovarian Follicles1

(2015) Karen Wigglesworth et al.   BIOLOGY OF REPRODUCTION

BMP4 and BMP7 Suppress StAR and Progesterone Production via ALK3 and SMAD1/5/8-SMAD4 in Human Granulosa-Lutein Cells

(2015) Han Zhang et al.   ENDOCRINOLOGY

Growth Differentiation Factor-8 Decreases StAR Expression Through ALK5-Mediated Smad3 and ERK1/2 Signaling Pathways in Luteinized Human Granulosa Cells

(2015) Lanlan Fang et al.   ENDOCRINOLOGY

Bone Morphogenetic Proteins Are Mediators of Luteolysis in the Human Corpus Luteum

(2015) Junko Nio-Kobayashi et al.   ENDOCRINOLOGY

Transforming growth factor-β1 up-regulates connexin43 expression in human granulosa cells

(2015) Yu-Ching Chen et al.   HUMAN REPRODUCTION

Genetics of primary ovarian insufficiency: new developments and opportunities

(2015) Yingying Qin et al.   HUMAN REPRODUCTION UPDATE

Recombinant BMP4 and BMP7 Downregulate Pentraxin 3 in Human Granulosa Cells

(2015) Hsun-Ming Chang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Recombinant BMP4 and BMP7 Increase Activin A Production by Up-Regulating Inhibin βA Subunit and Furin Expression in Human Granulosa-Lutein Cells

(2015) Hsun-Ming Chang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Growth differentiation factor 8 down-regulates pentraxin 3 in human granulosa cells

(2015) Hsun-Ming Chang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Activin A, B and AB decrease progesterone production by down-regulating StAR in human granulosa cells

(2015) Hsun-Ming Chang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

BMP gradients: A paradigm for morphogen-mediated developmental patterning

(2015) E. Bier et al.   SCIENCE

Molecular Biology of Endometriosis: From Aromatase to Genomic Abnormalities

(2015) Diana Monsivais et al.   SEMINARS IN REPRODUCTIVE MEDICINE

The bone morphogenetic protein system and the regulation of ovarian follicle development in mammals

(2015) Rodrigo O.D.S. Rossi et al.   ZYGOTE

GDF9 is Transiently Expressed in Oocytes before Follicle Formation in the Human Fetal Ovary and is Regulated by a Novel NOBOX Transcript

(2015) Rosemary A. L. Bayne et al.   PLoS One

Bone Morphogenetic Protein 2 Stimulates Noncanonical SMAD2/3 Signaling via the BMP Type 1A Receptor in Gonadotrope-Like Cells: Implications for FSH Synthesis

(2014) Ying Wang et al.   ENDOCRINOLOGY

The fundamental role of bone morphogenetic protein 15 in ovarian function and its involvement in female fertility disorders

(2014) Luca Persani et al.   HUMAN REPRODUCTION UPDATE

Reduced and delayed expression of GDF9 and BMP15 in ovarian tissues from women with polycystic ovary syndrome

(2014) Li-Na Wei et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Incorporation of Pentraxin 3 into Hyaluronan Matrices Is Tightly Regulated and Promotes Matrix Cross-linking

(2014) Natalia S. Baranova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myostatin Is Localized in Extravillous Trophoblast and Up-Regulates Migration

(2014) Hassendrini N. Peiris et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Effects of Recombinant Activins on Steroidogenesis in Human Granulosa-Lutein Cells

(2014) Hsun-Ming Chang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Aberrant GDF9 Expression and Activation Are Associated With Common Human Ovarian Disorders

(2014) Courtney M. Simpson et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Role of Activin-A and Myostatin and Their Signaling Pathway in Human Myometrial and Leiomyoma Cell Function

(2014) Md Soriful Islam et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Growth/differentiation factor-5: pre-clinical and clinical evaluations of periodontal regeneration and alveolar augmentation - review

(2014) Jaebum Lee et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Oocyte-derived BMP15 but not GDF9 down-regulates connexin43 expression and decreases gap junction intercellular communication activity in immortalized human granulosa cells

(2014) Hsun-Ming Chang et al.   MOLECULAR HUMAN REPRODUCTION

Increased GDF9 and BMP15 mRNA levels in cumulus granulosa cells correlate with oocyte maturation, fertilization, and embryo quality in humans

(2014) Yi Li et al.   Reproductive Biology and Endocrinology

Activin receptor-like kinase 1 as a target for anti-angiogenesis therapy

(2013) Lukas JAC Hawinkels et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Novel bone morphogenetic protein signaling through Smad2 and Smad3 to regulate cancer progression and development

(2013) Alisha Holtzhausen et al.   FASEB JOURNAL

Identification of a mutation in GDF9 as a novel cause of diminished ovarian reserve in young women

(2013) T.-T. Wang et al.   HUMAN REPRODUCTION

Transcriptional profiling of endometriosis tissues identifies genes related to organogenesis defects

(2013) Stefania Crispi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

EGF-like Growth Factors Induce COX-2–Derived PGE2 Production Through ERK1/2 in Human Granulosa Cells

(2013) Lanlan Fang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Theca-Derived BMP4 and BMP7 Down-Regulate Connexin43 Expression and Decrease Gap Junction Intercellular Communication Activity in Immortalized Human Granulosa Cells

(2013) Hsun-Ming Chang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension

(2013) Edda Spiekerkoetter et al.   JOURNAL OF CLINICAL INVESTIGATION

BMPR2 is required for postimplantation uterine function and pregnancy maintenance

(2013) Takashi Nagashima et al.   JOURNAL OF CLINICAL INVESTIGATION

Multiple-dose, safety, pharmacokinetic, and pharmacodynamic study of sotatercept (ActRIIA-IgG1), a novel erythropoietic agent, in healthy postmenopausal women

(2013) Matthew L. Sherman et al.   JOURNAL OF CLINICAL PHARMACOLOGY

BMP15 Suppresses Progesterone Production by Down-Regulating StAR via ALK3 in Human Granulosa Cells

(2013) Hsun-Ming Chang et al.   MOLECULAR ENDOCRINOLOGY

Expression of TGF-beta superfamily growth factors, their receptors, the associated SMADs and antagonists in five isolated size-matched populations of pre-antral follicles from normal human ovaries

(2013) Stine Gry Kristensen et al.   MOLECULAR HUMAN REPRODUCTION

Positive Selection in Bone Morphogenetic Protein 15 Targets a Natural Mutation Associated with Primary Ovarian Insufficiency in Human

(2013) Sylvain Auclair et al.   PLoS One

Growth differentiation factor 9:bone morphogenetic protein 15 (GDF9:BMP15) synergism and protein heterodimerization

(2013) D. G. Mottershead et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Growth differentiation factor 9:bone morphogenetic protein 15 heterodimers are potent regulators of ovarian functions

(2013) J. Peng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RUNX2, GPX3 and PTX3 gene expression profiling in cumulus cells are reflective oocyte/embryo competence and potentially reliable predictors of embryo developmental competence in PCOS patients

(2013) Xin Huang et al.   Reproductive Biology and Endocrinology

Bone morphogenetic proteins and the polycystic ovary syndrome

(2013) E Leonie AF van Houten et al.   Journal of Ovarian Research

Activin-Like Kinase 2 Functions in Peri-implantation Uterine Signaling in Mice and Humans

(2013) Caterina Clementi et al.   PLoS Genetics

Myostatin inhibitors as therapies for muscle wasting associated with cancer and other disorders

(2013) Rosamund C. Smith et al.   Current Opinion in Supportive and Palliative Care

Establishment of a Human Nonluteinized Granulosa Cell Line that Transitions from the Gonadotropin-Independent to the Gonadotropin-Dependent Status

(2012) Bayasula et al.   ENDOCRINOLOGY

BMP system expression in GCs from polycystic ovary syndrome women and the in vitro effects of BMP4, BMP6, and BMP7 on GC steroidogenesis

(2012) Mohamad Khalaf et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Promiscuity and specificity in BMP receptor activation

(2012) Thomas D. Mueller et al.   FEBS LETTERS

Myostatin and its association with abdominal obesity, androgen and follistatin levels in women with polycystic ovary syndrome

(2012) M.-J. Chen et al.   HUMAN REPRODUCTION

Alterations of maternal serum and placental follistatin-like 3 and myostatin in pre-eclampsia

(2012) Jing Guo et al.   JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH

Clinical characteristics and genetic analysis in women with premature ovarian insufficiency

(2012) Eleonora Ferrarini et al.   MATURITAS

The biology and therapeutic targeting of the proprotein convertases

(2012) Nabil G. Seidah et al.   NATURE REVIEWS DRUG DISCOVERY

Bone morphogenetic protein-15 in follicle fluid combined with age may differentiate between successful and unsuccessful poor ovarian responders

(2012) Yan-Ting Wu et al.   Reproductive Biology and Endocrinology

Elevated progesterone during ovarian stimulation for IVF

(2012) M. Al-Azemi et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Co-expression of bone morphogenetic protein 6 with estrogen receptor a in endometriosis

(2011) Farfaras Athanasios et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

Cell-type specific regulation of myostatin signaling

(2011) Dwi U. Kemaladewi et al.   FASEB JOURNAL

Prodomains regulate the synthesis, extracellular localisation and activity of TGF-β superfamily ligands

(2011) Craig A. Harrison et al.   GROWTH FACTORS

Ovarian antral folliculogenesis during the human menstrual cycle: a review

(2011) Angela R. Baerwald et al.   HUMAN REPRODUCTION UPDATE

Use and efficacy of bone morphogenetic proteins in fracture healing

(2011) Suzanne N. Lissenberg-Thunnissen et al.   INTERNATIONAL ORTHOPAEDICS

Mutational analysis of human bone morphogenetic protein 15 in Chinese women with polycystic ovary syndrome

(2011) Jingjing Liu et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

BMP2, BMP4, noggin, BMPRIA, BMPRIB, and BMPRII are differentially expressed in the adult rat spinal cord

(2011) M. Miyagi et al.   NEUROSCIENCE

Bone Morphogenetic Protein-2 (BMP-2) Increases Gene Expression of FSH Receptor and Aromatase and Decreases Gene Expression of LH Receptor and StAR in Human Granulosa Cells

(2010) Jia Shi et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Bone morphogenetic protein and growth differentiation factor cytokine families and their protein antagonists

(2010) Christopher C. Rider et al.   BIOCHEMICAL JOURNAL

Does Bone Morphogenetic Protein 6 (BMP6) Affect Female Fertility in the Mouse?1

(2010) Koji Sugiura et al.   BIOLOGY OF REPRODUCTION

Androgen excess down-regulates connexin43 in a human granulosa cell line

(2010) Cheng-Hsuan Wu et al.   FERTILITY AND STERILITY

Bone morphogenetic protein 2 may be a good predictor of success in oocyte fertilization during assisted reproductive technology

(2010) Rie SUGIYAMA et al.   Human Cell

Variants of the BMP15 gene in a cohort of patients with premature ovarian failure

(2010) D. Tiotiu et al.   HUMAN REPRODUCTION

Extra- and intra-ovarian factors in polycystic ovary syndrome: impact on oocyte maturation and embryo developmental competence

(2010) J. Qiao et al.   HUMAN REPRODUCTION UPDATE

Growth Differentiation Factor 9 Reverses Activin A Suppression of Steroidogenic Acute Regulatory Protein Expression and Progesterone Production in Human Granulosa-Lutein Cells

(2010) Feng-Tao Shi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Genes involved in human premature ovarian failure

(2010) Luca Persani et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

The human oocyte and cumulus cells relationship: new insights from the cumulus cell transcriptome

(2010) Zhongwei Huang et al.   MOLECULAR HUMAN REPRODUCTION

BMP-2/6 Heterodimer Is More Effective than BMP-2 or BMP-6 Homodimers as Inductor of Differentiation of Human Embryonic Stem Cells

(2010) Elvira Valera et al.   PLoS One

Anti-Müllerian hormone remains highly expressed in human cumulus cells during the final stages of folliculogenesis

(2010) M.L. Grøndahl et al.   REPRODUCTIVE BIOMEDICINE ONLINE

BMPs: From Bone to Body Morphogenetic Proteins

(2010) D. Obradovic Wagner et al.   Science Signaling

BMP Signaling in the Human Fetal Ovary is Developmentally Regulated and Promotes Primordial Germ Cell Apoptosis

(2010) Andrew J. Childs et al.   STEM CELLS

Mural granulosa cell gene expression associated with oocyte developmental competence

(2010) Jin-Yi Jiang et al.   Journal of Ovarian Research

Extensive sequence turnover of the signal peptides of members of the GDF/BMP family: exploring their evolutionary landscape

(2009) Reiner A Veitia et al.   Biology Direct

Expression of growth differentiation factor-9 and bone morphogenetic protein-15 in oocytes and cumulus granulosa cells of patients with polycystic ovary syndrome

(2009) Shu-Yun Zhao et al.   FERTILITY AND STERILITY

Effects of Endogenous Growth Differentiation Factor 9 on Activin A-Induced Inhibin B Production in Human Granulosa-Lutein Cells

(2009) Feng-Tao Shi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis

(2009) Shawn C. Little et al.   NATURE CELL BIOLOGY

Epidermal Growth Factor-Like Growth Factors in the Follicular Fluid: Role in Oocyte Development and Maturation

(2009) Minnie Hsieh et al.   SEMINARS IN REPRODUCTIVE MEDICINE

The Proregion of Mouse BMP15 Regulates the Cooperative Interactions of BMP15 and GDF91

(2008) C. Joy McIntosh et al.   BIOLOGY OF REPRODUCTION

Granulosa–lutein cell growth differentiation factor-9 (GDF-9) messenger RNA and protein expression in in vitro fertilization (IVF) cycles: relation to characteristics of ovulation induction and IVF

(2008) Hong-Yuan Huang et al.   FERTILITY AND STERILITY

Bone morphogenetic protein 15 expression in human ovaries from fetuses, girls, and women

(2008) Sima Margulis et al.   FERTILITY AND STERILITY

Atelocollagen-mediated local and systemic applications of myostatin-targeting siRNA increase skeletal muscle mass

(2008) N Kinouchi et al.   GENE THERAPY

Follicle dynamics and anovulation in polycystic ovary syndrome

(2008) S. Franks et al.   HUMAN REPRODUCTION UPDATE

Oocyte-secreted factors: regulators of cumulus cell function and oocyte quality

(2008) Robert B. Gilchrist et al.   HUMAN REPRODUCTION UPDATE

Regulation of granulosa and theca cell transcriptomes during ovarian antral follicle development

(2008) Michael K. Skinner et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Expression of bone morphogenetic proteins 4 and 7 and their receptors IA, IB, and II in human ovaries from fetuses and adults

(2007) Ronit Abir et al.   FERTILITY AND STERILITY

Association of genetic markers within the BMP15 gene with anovulation and infertility in women with polycystic ovary syndrome

(2007) Alejandro Gónzalez et al.   FERTILITY AND STERILITY

Gap junctions in the ovary: Expression, localization and function

(2007) Eran Gershon et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY