The fundamental role of bone morphogenetic protein 15 in ovarian function and its involvement in female fertility disorders

Aberrant GDF9 Expression and Activation Are Associated With Common Human Ovarian Disorders

(2014) Courtney M. Simpson et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Genetic defects of ovarian TGF-β-like factors and premature ovarian failure

(2014) L. Persani et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

A missense mutation in growth differentiation factor 9 (GDF9) is strongly associated with litter size in sheep

(2013) Dag I Våge et al.   BMC GENETICS

Coco regulates dorsoventral specification of germ layers via inhibition of TGF  signalling

(2013) T. J. D. Bates et al.   DEVELOPMENT

Investigations of TGF-β Signaling in Preantral Follicles of Female Mice Reveal Differential Roles for Bone Morphogenetic Protein 15

(2013) Mark A. Fenwick et al.   ENDOCRINOLOGY

Species Differences in the Expression and Activity of Bone Morphogenetic Protein 15

(2013) Sara L. Al-Musawi et al.   ENDOCRINOLOGY

Identification of a mutation in GDF9 as a novel cause of diminished ovarian reserve in young women

(2013) T.-T. Wang et al.   HUMAN REPRODUCTION

Inhibitory effects of controlled ovarian stimulation on the expression of GDF9 and BMP15 in oocytes from women with PCOS

(2013) Li-Na Wei et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

BMP15 Suppresses Progesterone Production by Down-Regulating StAR via ALK3 in Human Granulosa Cells

(2013) Hsun-Ming Chang et al.   MOLECULAR ENDOCRINOLOGY

Positive Selection in Bone Morphogenetic Protein 15 Targets a Natural Mutation Associated with Primary Ovarian Insufficiency in Human

(2013) Sylvain Auclair et al.   PLoS One

Growth differentiation factor 9:bone morphogenetic protein 15 (GDF9:BMP15) synergism and protein heterodimerization

(2013) D. G. Mottershead et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Growth differentiation factor 9:bone morphogenetic protein 15 heterodimers are potent regulators of ovarian functions

(2013) J. Peng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bone morphogenetic protein 15 and fibroblast growth factor 10 enhance cumulus expansion, glucose uptake, and expression of genes in the ovulatory cascade during in vitro maturation of bovine cumulus–oocyte complexes

(2013) Ester S Caixeta et al.   REPRODUCTION

Genome-Wide Association Studies Identify Two Novel BMP15 Mutations Responsible for an Atypical Hyperprolificacy Phenotype in Sheep

(2013) Julie Demars et al.   PLoS Genetics

A Covalently Dimerized Recombinant Human Bone Morphogenetic Protein-15 Variant Identifies Bone Morphogenetic Protein Receptor Type 1B as a Key Cell Surface Receptor on Ovarian Granulosa Cells

(2012) Minna M. Pulkki et al.   ENDOCRINOLOGY

Single-cell expression analysis of BMP15 and GDF9 in mature oocytes and BMPR2 in cumulus cells of women with polycystic ovary syndrome undergoing controlled ovarian hyperstimulation

(2012) Luciana Ochuiuto Teixeira de Resende et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Clinical characteristics and genetic analysis in women with premature ovarian insufficiency

(2012) Eleonora Ferrarini et al.   MATURITAS

Effects of species differences on oocyte regulation of granulosa cell function

(2012) Jia Yi Lin et al.   REPRODUCTION

Bone morphogenetic protein-15 in follicle fluid combined with age may differentiate between successful and unsuccessful poor ovarian responders

(2012) Yan-Ting Wu et al.   Reproductive Biology and Endocrinology

Influence of follicular fluid GDF9 and BMP15 on embryo quality

(2011) Funda Gode et al.   FERTILITY AND STERILITY

Abnormal expression of growth differentiation factor 9 and bone morphogenetic protein 15 in stimulated oocytes during maturation from women with polycystic ovary syndrome

(2011) Li-Na Wei et al.   FERTILITY AND STERILITY

Genomic analysis using high-resolution single-nucleotide polymorphism arrays reveals novel microdeletions associated with premature ovarian failure

(2011) Megan M. McGuire et al.   FERTILITY AND STERILITY

Exogenous GDF9 but not Activin A, BMP15 or TGFβ alters tight junction protein transcript abundance in zebrafish ovarian follicles

(2011) Eric S. Clelland et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Mutational analysis of human bone morphogenetic protein 15 in Chinese women with polycystic ovary syndrome

(2011) Jingjing Liu et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Signalling pathways mediating specific synergistic interactions between GDF9 and BMP15

(2011) D. G. Mottershead et al.   MOLECULAR HUMAN REPRODUCTION

Signalling pathways involved in the cooperative effects of ovine and murine GDF9+BMP15-stimulated thymidine uptake by rat granulosa cells

(2011) Karen L Reader et al.   REPRODUCTION

Active immunization against the proregions of GDF9 or BMP15 alters ovulation rate and litter size in mice

(2011) C Joy McIntosh et al.   REPRODUCTION

A single nucleotide polymorphism in BMP15 is associated with high response to ovarian stimulation

(2011) Hans Ivar Hanevik et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Transforming Growth Factor β Receptor Type 1 Is Essential for Female Reproductive Tract Integrity and Function

(2011) Qinglei Li et al.   PLoS Genetics

A new polymorphism in the Growth and Differentiation Factor 9 (GDF9) gene is associated with increased ovulation rate and prolificacy in homozygous sheep

(2010) B. D. M. Silva et al.   ANIMAL GENETICS

Association study of four key folliculogenesis genes in polycystic ovary syndrome

(2010) K Sproul et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Variants of the BMP15 gene in a cohort of patients with premature ovarian failure

(2010) D. Tiotiu et al.   HUMAN REPRODUCTION

Detecting a deletion in the coding region of the bovine bone morphogenetic protein 15 gene (BMP15)

(2010) L. P. Zhang et al.   JOURNAL OF APPLIED GENETICS

Prodomains of Transforming Growth Factor β (TGFβ) Superfamily Members Specify Different Functions

(2010) Gerhard Sengle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genes involved in human premature ovarian failure

(2010) Luca Persani et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Impaired production of BMP-15 and GDF-9 mature proteins derived from proproteins WITH mutations in the proregion

(2010) Kenichi Inagaki et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The bioactivity of human bone morphogenetic protein-15 is sensitive to C-terminal modification: Characterization of the purified untagged processed mature region

(2010) Minna M. Pulkki et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Integral role of GDF-9 and BMP-15 in ovarian function

(2010) Fumio Otsuka et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Analyses of growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) mutation in Chinese women with premature ovarian failure

(2009) Binbin Wang et al.   CLINICAL ENDOCRINOLOGY

BMP15 mutations associated with primary ovarian insufficiency cause a defective production of bioactive protein

(2009) Raffaella Rossetti et al.   HUMAN MUTATION

Primary ovarian insufficiency: X chromosome defects and autoimmunity

(2009) Luca Persani et al.   JOURNAL OF AUTOIMMUNITY

Bone Morphogenetic Protein 15 (BMP15) Acts as a BMP and Wnt Inhibitor during Early Embryogenesis

(2009) Elisa Di Pasquale et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oocyte peptides as paracrine tools for ovarian stimulation and oocyte maturation

(2009) D. G. Mottershead et al.   MOLECULAR HUMAN REPRODUCTION

Stable expression and characterization of N-terminal tagged recombinant human bone morphogenetic protein 15

(2009) Q. Li et al.   MOLECULAR HUMAN REPRODUCTION

Effects of active immunization against growth differentiation factor 9 and/or bone morphogenetic protein 15 on ovarian function in cattle

(2009) Jennifer L Juengel et al.   REPRODUCTION

Homozygosity for a single base-pair mutation in the oocyte-specific GDF9 gene results in sterility in Thoka sheep

(2009) Linda Nicol et al.   REPRODUCTION

Identification of Potential Markers of Oocyte Competence Expressed in Bovine Cumulus Cells Matured with Follicle-Stimulating Hormone and/or Phorbol Myristate Acetate In Vitro

(2008) Mourad Assidi et al.   BIOLOGY OF REPRODUCTION

The Proregion of Mouse BMP15 Regulates the Cooperative Interactions of BMP15 and GDF91

(2008) C. Joy McIntosh et al.   BIOLOGY OF REPRODUCTION

Oocyte-Specific Overexpression of Mouse Bone Morphogenetic Protein-15 Leads to Accelerated Folliculogenesis and an Early Onset of Acyclicity in Transgenic Mice

(2008) Heather E. McMahon et al.   ENDOCRINOLOGY

Variation in bone morphogenetic protein 15 is not associated with spontaneous human dizygotic twinning

(2008) Z. Z. Zhao et al.   HUMAN REPRODUCTION

Oocyte-secreted factors: regulators of cumulus cell function and oocyte quality

(2008) Robert B. Gilchrist et al.   HUMAN REPRODUCTION UPDATE

Characterization of the post-translational modification of recombinant human BMP-15 mature protein

(2008) Seiji Saito et al.   PROTEIN SCIENCE

BMP15 mutations in XX gonadal dysgenesis and premature ovarian failure

(2007) Susanne Ledig et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Association of genetic markers within the BMP15 gene with anovulation and infertility in women with polycystic ovary syndrome

(2007) Alejandro Gónzalez et al.   FERTILITY AND STERILITY