Review
Medicine, General & Internal
Stefan K. Zoellner, James E. Amatruda, Sebastian Bauer, Stephane Collaud, Enrique de Alava, Steven G. DuBois, Jendrik Hardes, Wolfgang Hartmann, Heinrich Kovar, Markus Metzler, David S. Shulman, Arne Streitbuerger, Beate Timmermann, Jeffrey A. Toretsky, Yasmin Uhlenbruch, Volker Vieth, Thomas G. P. Gruenewald, Uta Dirksen
Summary: Ewing sarcoma is a highly aggressive bone and soft-tissue cancer with a genetically simple yet specific therapeutic target. Current standard treatment involving systemic therapy and local treatment provides a realistic chance of cure for the majority of patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cell Biology
Ana Cristina Vargas, Nima M. Ardakani, Daniel D. Wong, Fiona M. Maclean, Joseph Kattampallil, Richard Boyle, Leonardo Santos, Anthony J. Gill
Summary: NTRK-rearranged sarcomas are a heterogeneous group of tumors with either relatively simple or complex karyotypes. Chromosomal copy number variations involve multiple chromosomes, with complex karyotypes associated with more aggressive clinical behavior. Gains at chromosome 6p and 1q were the most common recurrent genetic alterations.
Review
Biochemistry & Molecular Biology
Evangelos Koustas, Panagiotis Sarantis, Michalis V. Karamouzis, Philippe Vielh, Stamatios Theocharis
Summary: Ewing Sarcoma is a rare and aggressive cancer in children and young adults, with controversial role of autophagy being explored in clinical trials. Caution is recommended in the application of autophagy as a therapeutic target, and future studies are needed to identify which patients may benefit from autophagy modulators for more efficient treatment protocols.
Article
Oncology
Oxana Schmidt, Nadja Nehls, Carolin Prexler, Kristina von Heyking, Tanja Groll, Katharina Pardon, Heathcliff D. Garcia, Tim Hensel, Dennis Guergen, Anton G. Henssen, Angelika Eggert, Katja Steiger, Stefan Burdach, Guenther H. S. Richter
Summary: Histone deacetylases (HDACs) class I are continuously expressed in Ewing sarcoma (EwS), with patients having high levels of individual class I HDAC expression showing decreased overall survival. Knockout of HDAC1 and HDAC2 inhibited invasiveness in EwS cells and blocked tumor growth in xenograft mice. Treatment with HDAC inhibitors enhanced susceptibility to chemotherapeutics and mimicked the effects of EZH2 RNAi, suggesting potential for combination therapy in treating this malignant disease.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Review
Cell Biology
Maryne Dupuy, Francois Lamoureux, Mathilde Mullard, Anais Postec, Laura Regnier, Marc Baud'huin, Steven Georges, Benedicte Brounais-Le Royer, Benjamin Ory, Francoise Redini, Franck Verrecchia
Summary: Ewing sarcoma (ES) is the second most common primary malignant bone tumor in children, adolescents, and young adults in Europe, with a survival rate of 70% for localized forms using conventional treatment. However, resistance to chemotherapy and pulmonary metastases greatly reduce the survival rate. ES is characterized by a chromosomal translocation that leads to the fusion protein EWS-FLI1, which plays a crucial role in the development of ES. This review provides an overview of ES from a clinical and biological perspective.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Cell Biology
Dave N. T. Aryee, Valerie Fock, Utkarsh Kapoor, Branka Radic-Sarikas, Heinrich Kovar
Summary: Ewing sarcoma is a rare aggressive cancer characterized by chromosomal translocation and expression of the EWS-FLI1 fusion protein. Exploring the role of long non-coding RNAs (lncRNAs) in tumorigenesis and metastasis may provide potential biomarkers and therapeutic targets for this disease.
Article
Medicine, Research & Experimental
Tetsuo Ohnishi, Yuji Kiyama, Fumiko Arima-Yoshida, Mitsutaka Kadota, Tomoe Ichikawa, Kazuyuki Yamada, Akiko Watanabe, Hisako Ohba, Kaori Tanaka, Akihiro Nakaya, Yasue Horiuchi, Yoshimi Iwayama, Manabu Toyoshima, Itone Ogawa, Chie Shimamoto-Mitsuyama, Motoko Maekawa, Shabeesh Balan, Makoto Arai, Mitsuhiro Miyashita, Kazuya Toriumi, Yayoi Nozaki, Rumi Kurokawa, Kazuhiro Suzuki, Akane Yoshikawa, Tomoko Toyota, Toshihiko Hosoya, Hiroyuki Okuno, Haruhiko Bito, Masanari Itokawa, Shigehiro Kuraku, Toshiya Manabe, Takeo Yoshikawa
Summary: The study reveals the gene expression regulation mechanism related to mental disorders by conducting experiments on Ldb2 knockout mice, highlighting the association between Ldb2 and the EGR family genes, providing new insights into the pathogenesis of mental disorders.
EMBO MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Muhammad Yasir, Jinyoung Park, Eun-Taek Han, Won Sun Park, Jin-Hee Han, Yong-Soo Kwon, Hee-Jae Lee, Mubashir Hassan, Andrzej Kloczkowski, Wanjoo Chun
Summary: In this study, a three-dimensional structure of DAX1 was modeled, and network analysis and molecular docking were conducted to evaluate the association of DAX1 with Ewing Sarcoma. Flavonoid compounds were found to interact with the active region of DAX1 and could potentially be used as therapeutic agents against DAX1-mediated augmentation of ES.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pathology
Karen J. Fritchie, Baptiste Ameline, Vanghelita Andrei, Christopher Griffith, Akeesha A. Shah, Josephine K. Dermawan, Matteo Trucco, Thomas Budd, Judith J. Thangaiah, Jeremy Molligan, Rumeal D. Whaley, Kelly Magliocca, Elizabeth Azzato, Annemieke van Zante, Vickie Jo, Bin Xu, Justin A. Bishop, Lisa Rooper, Daniel Baumhoer
Summary: This study explored the relationship between Ewing sarcoma and ALES using DNA methylation profiling. The results showed that ALES has a distinct methylation signature from conventional Ewing sarcoma. This finding strengthens the understanding that ALES should be considered a separate entity from Ewing sarcoma.
Article
Biochemistry & Molecular Biology
Muhammad Yasir, Jinyoung Park, Eun-Taek Han, Won Sun Park, Jin-Hee Han, Yong-Soo Kwon, Hee-Jae Lee, Mubashir Hassan, Andrzej Kloczkowski, Wanjoo Chun
Summary: Ewing sarcoma (ES) is a highly malignant carcinoma prevalent in children, and a translocation-encoded fusion protein EWS/FLI is essential for ES formation. In this study, flavonoid compounds were selected to disrupt the RNA-binding motif of EWS, and molecular docking and dynamics simulations were performed to validate their binding interactions and stability. Daidzein, kaempferol, and genistein showed comparable results to ifosfamide and could be potential candidate compounds for further in vitro studies against ES.
Article
Biochemistry & Molecular Biology
Ziva Zajec, Jaka Dernovsek, Martin Distel, Martina Gobec, Tihomir Tomasic
Summary: In this article, a new class of allosteric Hsp90 C-terminal domain (CTD) inhibitors based on the virtual screening hit TVS24 is reported, which showed anti-proliferative activity in the SK-N-MC Ewing sarcoma cell line. The optimized compounds exhibited enhanced anticancer activity in the SK-N-MC cell line. Exposure to the most potent analogue 11c depleted critical Hsp90 client proteins involved in cancer pathways without inducing a heat shock response. This study highlights Hsp90 CTD inhibitors as promising new agents for the treatment of Ewing sarcoma.
BIOORGANIC CHEMISTRY
(2023)
Article
Oncology
Matthew T. T. Houdek, Mark J. J. Heidenreich, Safia K. K. Ahmed, Wendy Allen-Rhoades, Brittany L. L. Siontis, Steven I. I. Robinson, Ivy A. A. Petersen, Peter S. S. Rose
Summary: The study evaluated the treatment experience of EES patients and found that chemotherapy and surgery can achieve excellent local control.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Review
Oncology
Asle Charles Hesla, Andri Papakonstantinou, Panagiotis Tsagkozis
Summary: Ewing sarcoma is a highly aggressive malignancy primarily affecting children and adolescents, characterized by a pathognomonic chromosomal translocation resulting in a fusion transcript. Despite the known fusion transcript for decades, new molecular techniques have improved our understanding of this rare disease. Treatment involves multiagent chemotherapy, radiation treatment, and surgery, with significant side effects.
Article
Oncology
Logan G. Spector, Aubrey K. Hubbard, Brandon J. Diessner, Mitchell J. Machiela, Beau Webber, Joshua D. Schiffman
Summary: Ewing sarcoma is the second most common primary bone tumor in children and adolescents, with few known epidemiological or genetic risk factors. Studies show significant variation in ES incidence across different geographic regions, indicating potential ancestral influence on disease risk.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Review
Biochemistry & Molecular Biology
Joon Hyuk Choi, Jae Y. Ro
Summary: Soft tissue tumors are rare mesenchymal tumors with diverse differentiation. They are challenging to diagnose due to the variety of tumor types and histological overlap. Advances in molecular genetic techniques and the development of immunohistochemical markers have improved our understanding of the molecular pathogenesis of soft tissue tumors. This review provides updated information on recent molecular findings and novel immunohistochemical markers in selected soft tissue tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Yong Joon Kim, Sung Chul Lee, Sung Eun Kim, Seo Hee Kim, Sang Kyum Kim, Christopher Seungkyu Lee
SCIENTIFIC REPORTS
(2020)
Article
Dermatology
Jimyung Seo, Yeongjoo Oh, Sang Kyum Kim, Mi Ryung Roh, Kee Yang Chung
Summary: The study found that slow Mohs micrographic surgery is an effective alternative to wide local excision for acral melanomas at anatomically complex sites, resulting in superior outcomes and maximum tissue conservation compared to traditional methods.
DERMATOLOGIC SURGERY
(2021)
Article
Oncology
Sang Kyum Kim, Jang-Hee Kim, Jae Ho Han, Nam Hoon Cho, Se Joong Kim, Sun Il Kim, Seol Ho Choo, Ji Su Kim, Bumhee Park, Ji Eun Kwon
Summary: This study found that TERT-p mutations are common in penile squamous cell carcinomas, especially in non-HPV-related cases. TERT-p mutations are associated with low histologic grade, low mitotic count, and other clinical features.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Oncology
Sang Kyum Kim, Jee Hung Kim, Seung Hyun Kim, Young Han Lee, Jung Woo Han, Wooyeol Baek, Ha Young Woo, Min Kyung Jeon, Hyo Song Kim
Summary: Based on the evaluation of PD-L1 expression in tumor tissues from advanced STS patients treated with pazopanib, it was found that PD-L1 expression can help predict the clinical outcome of pazopanib therapy, with PD-L1 positive tumors showing poorer response to treatment.
Article
Multidisciplinary Sciences
Jiyeon An, Ha Young Woo, Younghan Lee, Hyo Song Kim, Juhyeon Jeong, Sang Kyum Kim
Summary: Desmoid-type fibromatosis (DF) is a locally aggressive neoplasm characterized by mutations in the CTNNB1 gene, with CTNNB1-mutant DF samples consistently displaying nuclear beta-catenin expression. Larger or excised DF tumors with CTNNB1 mutations tend to exhibit nuclear beta-catenin expression, and males show a higher frequency of T41A or T41I mutations.
Article
Endocrinology & Metabolism
Seunghyun Lee, Namki Hong, Sungjae Shin, Sun Il Kim, Mijin Yun, Sang Kyum Kim, Yumie Rhee
Summary: This study compared the performance of SSTR2A and FGF23 immunohistochemistry (IHC) in diagnosing tumor-induced osteomalacia (TIO). The results indicate that SSTR2A IHC with H-score quantification might be a more sensitive diagnostic tool for TIO than FGF23 IHC.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Cell Biology
Hyang-Joo Ryu, Sun-Il Kim, Hyung-Ook Jang, Se-Hoon Kim, Sang-Ho Oh, Sujin Park, Sang-Kyum Kim
Summary: The study found that CD5 and CD7 expression differed significantly between early MF and non-MF cases, and TCR-gamma and beta chain rearrangements were more frequently detected in early MF. These findings emphasize the importance of these factors in the diagnosis of early MF.
Article
Medicine, General & Internal
Ha Young Woo, Sang Kyum Kim
Summary: Nevus comedonicus is a rare hamartoma of the pilosebaceous unit. This report presents the first case of NC syndrome associated with mood disorder and ADHD. Psychiatric symptoms may represent a systemic manifestation of NCS.
Article
Oncology
Chang Gon Kim, Nam Suk Sim, Jeong Eun Kim, Kum -Hee Yun, Young Han Lee, Seung Hyun Kim, Wooyeol Baek, Yoon Dae Han, Sang Kyum Kim, Jee Hung Kim, Yoon Woo Koh, Inkyung Jung, Su-Jin Shin, Sun Young Rha, Jin-Hee Ahn, Hyo Song Kim
Summary: This study evaluated the efficacy and safety of eribulin-gemcitabine combination therapy in liposarcoma and leiomyosarcoma patients. The results showed promising activity and an acceptable safety profile for this combination treatment. Gene expression profiling and pathway enrichment analysis may have predictive value for survival outcome, but further investigation is needed.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Yeongjoo Oh, Zhenlong Zheng, Ki-Yeol Kim, Xiangshu Xu, Meiling Pei, Byungho Oh, Sang Kyem Kim, Kee Yang Chung, Mi Ryung Roh
Summary: A powerful risk prediction model for cSCC recurrence was constructed by combining clinical factors and biomarkers into a nomogram.
Article
Dermatology
Chang Gon Kim, Miso Kim, Jieon Hwang, Seung Tae Kim, Minkyu Jung, Kyoo Hyun Kim, Kyung Hwan Kim, Jee Suk Chang, Woong Sub Koom, Mi Ryung Roh, Kee Yang Chung, Tae Min Kim, Sang Kyum Kim, Jeeyun Lee, Sang Joon Shin
Summary: This study compared the outcomes of first-line pembrolizumab and dabrafenib/trametinib treatment for patients with advanced melanoma with BRAF mutations. The results showed that first-line pembrolizumab treatment resulted in longer overall survival, suggesting it may be a better treatment option.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Oncology
Jung Yong Hong, Hee Jin Cho, Kum-Hee Yun, Young Han Lee, Seung Hyun Kim, Wooyeol Baek, Sang Kyum Kim, Yurimi Lee, Yoon-La Choi, Minsuk Kwon, Hyo Song Kim, Jeeyun Lee
Summary: This study investigated the molecular determinants of pazopanib response in refractory soft tissue sarcoma patients. It identified CDK4 amplification as a predictor of poor response and shorter progression-free survival. Additionally, the combination of pazopanib and durvalumab showed efficacy in patients with high immune/stromal cell infiltration and increased CD19 expression.
CANCER RESEARCH AND TREATMENT
(2023)
Article
Medicine, General & Internal
Mi Youn Seol, Seo Hee Choi, Ik Jae Lee, Hyung Soon Park, Hye Ryun Kim, Sang Kyum Kim, Hong In Yoon
Summary: This study investigated whether selective inhibition of PI3K isoforms could enhance radiosensitivity in GBM. The results from cell experiments and a mouse model demonstrated that inhibition of PI3K-alpha isoform increased radiosensitivity in GBM cells, leading to tumor growth suppression and extended survival in vivo.
YONSEI MEDICAL JOURNAL
(2023)
Article
Medicine, Research & Experimental
Hyenguk Jang, Hyang Joo Ryu, Sang Kyum Kim
Summary: This study analyzed the genetic alterations of primary cutaneous melanomas in the Korean population and compared them to melanomas in Western populations. The results showed differences in genetic alterations between Asian and Western populations.
Article
Oncology
Kum-Hee Yun, Changhee Park, Hyang Joo Ryu, Chan-Young Ock, Young Han Lee, Wooyeol Baek, Hong In Yoon, Yoon Dae Han, Sang Kyum Kim, JooHee Lee, Seong-Jin Kim, Kyung-Min Yang, Seung Hyun Kim, Hyo Song Kim
Summary: This study identified gene sets related to the TGF-beta signaling pathway, suggesting the potential of TGF-beta inhibitors as a treatment option for desmoid tumors. Preclinical models validated the anti-tumor effect of combination therapy.
