Absence of alsin function leads to corticospinal motor neuron vulnerability via novel disease mechanisms

The receptor proteins: pivotal roles in selective autophagy

(2015) Zhijie Xu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Corticospinal Motor Neurons Are Susceptible to Increased ER Stress and Display Profound Degeneration in the Absence of UCHL1 Function

(2015) Javier H. Jara et al.   CEREBRAL CORTEX

Expanding the ubiquitin code through post-translational modification

(2015) L. Herhaus et al.   EMBO REPORTS

Rho guanine nucleotide exchange factors involved in cyclic-stretch-induced reorientation of vascular endothelial cells

(2015) H. Abiko et al.   JOURNAL OF CELL SCIENCE

Parkin‐independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain

(2014) Yusuke Kageyama et al.   EMBO JOURNAL

A novel homozygous mutation in ALS2 gene in four siblings with infantile-onset ascending hereditary spastic paralysis

(2014) Hatice Koçak Eker et al.   European Journal of Medical Genetics

A novel SOD1-ALS mutation separates central and peripheral effects of mutant SOD1 toxicity

(2014) Peter I. Joyce et al.   HUMAN MOLECULAR GENETICS

Delayed Disease Onset and Extended Survival in the SOD1G93A Rat Model of Amyotrophic Lateral Sclerosis after Suppression of Mutant SOD1 in the Motor Cortex

(2014) G. M. Thomsen et al.   JOURNAL OF NEUROSCIENCE

Retrograde labeling, transduction, and genetic targeting allow cellular analysis of corticospinal motor neurons: implications in health and disease

(2014) Javier H. Jara et al.   Frontiers in Neuroanatomy

Infantile-onset ascending hereditary spastic paraplegia with bulbar involvement due to the novel ALS2 mutation c.2761C>T

(2013) Salma M. Wakil et al.   GENE

Abnormal mitochondrial transport and morphology are common pathological denominators in SOD1 and TDP43 ALS mouse models

(2013) Jordi Magrané et al.   HUMAN MOLECULAR GENETICS

eGFP Expression under UCHL1 Promoter Genetically Labels Corticospinal Motor Neurons and a Subpopulation of Degeneration-Resistant Spinal Motor Neurons in an ALS Mouse Model

(2013) M. V. Yasvoina et al.   JOURNAL OF NEUROSCIENCE

Are alsin and spartin novel interaction partners?

(2012) Gönenç Çobanoğlu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

AAV2 mediated retrograde transduction of corticospinal motor neurons reveals initial and selective apical dendrite degeneration in ALS

(2012) Javier H. Jara et al.   NEUROBIOLOGY OF DISEASE

Simple Neurite Tracer: open source software for reconstruction, visualization and analysis of neuronal processes

(2011) M. H. Longair et al.   BIOINFORMATICS

p62/SQSTM1 in autophagic clearance of a non-ubiquitylated substrate

(2011) Y. Watanabe et al.   JOURNAL OF CELL SCIENCE

Corticospinal Motor Neurons and Related Subcerebral Projection Neurons Undergo Early and Specific Neurodegeneration in hSOD1G93A Transgenic ALS Mice

(2011) P. H. Ozdinler et al.   JOURNAL OF NEUROSCIENCE

p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both

(2010) Derek Narendra et al.   Autophagy

Parkin-mediated selective mitochondrial autophagy, mitophagy: Parkin purges damaged organelles from the vital mitochondrial network

(2010) Atsushi Tanaka   FEBS LETTERS

Sublayer-specific microcircuits of corticospinal and corticostriatal neurons in motor cortex

(2010) Charles T Anderson et al.   NATURE NEUROSCIENCE

Modelling neurodegeneration in Saccharomyces cerevisiae: why cook with baker's yeast?

(2010) Vikram Khurana et al.   NATURE REVIEWS NEUROSCIENCE

Genetic background and gender effects on gross phenotypes in congenic lines of ALS2/alsin-deficient mice

(2010) Shinji Hadano et al.   NEUROSCIENCE RESEARCH

ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import

(2010) Q. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of endosomal motility and degradation by amyotrophic lateral sclerosis 2/alsin

(2009) Chen Lai et al.   Molecular Brain

Descending Pathways in Motor Control

(2008) Roger N. Lemon   Annual Review of Neuroscience

ALS2/alsin deficiency in neurons leads to mild defects in macropinocytosis and axonal growth

(2008) Asako Otomo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

ALS2/Alsin Knockout Mice and Motor Neuron Diseases

(2008) Huaibin Cai et al.   Neurodegenerative Diseases

Molecular interaction of neurocalcin α with alsin (ALS2)

(2008) Toshinori Masutani et al.   NEUROSCIENCE LETTERS