Article
Radiology, Nuclear Medicine & Medical Imaging
Monika Gloor, Michaela Andelova, Laura Gaetano, Athina Papadopoulou, Federico Burguet Villena, Till Sprenger, Ernst-Wilhelm Radue, Ludwig Kappos, Oliver Bieri, Meritxell Garcia
Summary: This study analyzed the potential of magnetization transfer imaging (MTI) and diffusion tensor imaging (DTI) for the detection and evolution of new multiple sclerosis (MS) lesions. The results showed that MTI provides more information than DTI and can detect tissue changes 2 to 4 months prior to their appearance on MRI.
EUROPEAN RADIOLOGY
(2023)
Article
Multidisciplinary Sciences
Naila Rahman, Kathy Xu, Matthew D. D. Budde, Arthur Brown, Corey A. A. Baron
Summary: Multimodal microstructural MRI has increased sensitivity and specificity in detecting changes in brain diseases and injuries. This article presents an in vivo longitudinal dataset, including a subset of ex vivo data, for studying microstructural changes in healthy mouse brains. The dataset includes various MRI methods and techniques for analyzing microstructural changes. The sharing of this dataset can contribute to the development of biophysical models and methods for studying temporal brain dynamics.
Article
Radiology, Nuclear Medicine & Medical Imaging
Nan Meng, Xuejia Wang, Jing Sun, Zhun Huang, Zhen Yang, Jie Shang, Yan Bai, Wei Wei, Dongming Han, Hui Han, Kaiyu Wang, Fengmin Shao, Meiyun Wang
Summary: Both DKI- and APTWI-related parameters have potential as imaging markers in estimating the histological features of EC, while DKI shows better performance than APTWI in this study.
EUROPEAN RADIOLOGY
(2021)
Article
Geriatrics & Gerontology
Stephanie Matijevic, Lee Ryan
Summary: The study found that age and sex have an impact on the cerebral white matter integrity of older adults, with a more significant effect on certain white matter tracts. Females exhibited lower global FA compared to males, but had higher MD in the anterior cingulum and superior longitudinal fasciculus. Age influenced both global FA and specific tract FA, while APOE epsilon 4 status did not show predictive power.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Neurosciences
Fanny Munsch, Gopal Varma, Manuel Taso, Olivier Girard, Arnaud Guidon, Guillaume Duhamel, David C. Alsop
Summary: The study implemented a 3D ihMT acquisition and analysis to characterize cortical gray matter myeloarchitecture, finding qualitative agreement between cortical ihMTsat and dual MTsat maps with previous work and cortical T(1)w map, but with important regional differences. The research demonstrated that ihMTsat shows unique contrast between cortical regions.
Article
Geriatrics & Gerontology
Emma L. Ducca, Gabriela T. Gomez, Priya Palta, Kevin J. Sullivan, Clifford R. Jack, David S. Knopman, Rebecca F. Gottesman, Jeremy Walston, B. Gwen Windham, Keenan A. Walker
Summary: The study found a strong association between cerebral white matter structure and current and future frailty. Specifically, white matter hyperintensity volume was significantly associated with frailty. However, measures of white matter microstructure were not generally associated with progression from nonfrail to frail status.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Review
Neurosciences
Alberto Lazari, Ilona Lipp
Summary: The study conducted a systematic review and meta-analysis on MRI-based myelin markers, finding correlations between various myelin histology metrics and markers from different MRI modalities, but no single most sensitive strategy to measure myelin with MRI. The authors provided a detailed characterization of the evaluated studies and 12 recommendations for future research.
Article
Cell Biology
Donnie Cameron, David A. Reiter, Fatemeh Adelnia, Ceereena Ubaida-Mohien, Christopher M. Bergeron, Seongjin Choi, Kenneth W. Fishbein, Richard G. Spencer, Luigi Ferrucci
Summary: Diffusion-tensor magnetic resonance imaging (DT-MRI) can objectively measure muscle characteristics and provide insights into age-related changes. In this study, DT-MRI was used to examine the microstructure and architecture of skeletal muscle in a large healthy aging cohort. The results showed age-related differences in muscle structure and differences in microstructure among different muscles.
Article
Medicine, General & Internal
Jeong-Pyo Seo, Heun Jae Ryu
Summary: Using diffusion tensor tractography (DTT), this study explored the aging of the mesolibic tract (MLT) in normal human participants and found a significant negative correlation between age and the voxel number (VN) of MLT, as well as a positive correlation between age and the apparent diffusion coefficient (ADC). Aging of MLT was observed to begin in the 20s or 30s and steadily progress throughout life until significant degeneration occurred in the 60s. This may play a role in the decline of memory and social interaction with aging in normal participants.
Article
Radiology, Nuclear Medicine & Medical Imaging
Shichao Li, Kangwen He, Guanjie Yuan, Xingwang Yong, Xiaoyan Meng, Cui Feng, Yi Zhang, Ihab R. Kamel, Zhen Li
Summary: ZOOMit DKI and CEST imaging can be valuable in predicting the WHO/ISUP grade and pathological T stage in ccRCC. Tumors with higher WHO/ISUP grades and pT stages tend to have lower ADC, MD, and S-sat (3.5 ppm)/S-0 values, while higher MK and MTRasym (3.5 ppm) values. The combination of MTRasym (3.5 ppm) and MD showed the best diagnostic performance for WHO/ISUP grading.
EUROPEAN RADIOLOGY
(2023)
Article
Neurosciences
Shannon Kelley, John Plass, Andrew R. Bender, Thad A. Polk
Summary: This study investigated age-related white matter differences using fixel-based analysis (FBA). The results revealed that age-related differences in FA were strongly associated with differences in multi-fiber complexity, indicating differences in crossing fibers and individual fiber segments. FBA also provided insights into distinct microstructural changes underlying age-related effects in specific brain regions.
Article
Neuroimaging
Jayachandra M. Raghava, Rene C. W. Mandl, Mette O. Nielsen, Birgitte Fagerlund, Birte Y. Glenthoj, Egill Rostrup, Bjorn H. Ebdrup
Summary: The study investigated cerebral white matter integrity in antipsychotic-naive, first-episode schizophrenia patients using diffusion tensor imaging (DTI) and magnetization transfer imaging (MTI. The results suggest disorganized white matter microstructure in patients, potentially related to neuroinflammation based on higher extracellular free-water concentrations in substance-free patients. Psychopathology was not significantly associated with the observed patterns, highlighting the importance of considering recreational substance use as a confounding factor in future white matter studies.
BRAIN IMAGING AND BEHAVIOR
(2021)
Article
Neurosciences
Alexandrine Morand, Shailendra Segobin, Gregory Lecouvey, Julie Gonneaud, Francis Eustache, Geraldine Rauchs, Beatrice Desgranges
Summary: This study found that older participants had lower gray matter volumes in several brain areas, but these did not correlate with TBPM performance. On the other hand, a decline in white matter integrity was correlated with TBPM performance, indicating a disconnection process that occurs in aging and contributes to cognitive decline.
Article
Computer Science, Artificial Intelligence
Alexis Reymbaut, Alex Valcourt Caron, Guillaume Gilbert, Filip Szczepankiewicz, Markus Nilsson, Simon K. Warfield, Maxime Descoteaux, Benoit Scherrer
Summary: Diffusion tensor imaging provides increased sensitivity to microstructural tissue changes compared to conventional anatomical imaging, but presents limited specificity. To address this issue, the DIAMOND model subdivides voxel content into diffusion compartments and estimates compartmental non-central matrix-variate Gamma distributions of diffusion tensors. Incorporating tensor-valued diffusion encoding, the Magic DIAMOND model demonstrates improved accuracy in estimating brain microstructural features, particularly in regions of fiber crossing.
MEDICAL IMAGE ANALYSIS
(2021)
Article
Multidisciplinary Sciences
Lipeng Ning, Filip Szczepankiewicz, Markus Nilsson, Yogesh Rathi, Carl-Fredrik Westin
Summary: The study introduces a new approach for analyzing diffusion MRI data using tensor-valued encoding technique, which can better characterize tissue microstructure. Novel imaging indices are derived to distinguish different ensembles of diffusion processes. The effectiveness of the proposed method is demonstrated using synthetic data and in vivo data from the human brain.
SCIENTIFIC REPORTS
(2021)
Review
Neurosciences
Shanti Van Malderen, Melina Hehl, Stefanie Verstraelen, Stephan P. Swinnen, Koen Cuypers
Summary: This paper reviews and summarizes the research on the inter- and intra-hemispheric interactions of dual-site transcranial magnetic stimulation (ds-TMS) and discusses its applicability and contributions to motor control. However, there is variability in the experimental context and stimulation parameters, calling for more systematic studies to address these issues.
REVIEWS IN THE NEUROSCIENCES
(2023)
Article
Oncology
Michelle Melis, Gwen Schroyen, Nicolas Leenaerts, Ann Smeets, Stefan Sunaert, Katleen Van der Gucht, Sabine Deprez
Summary: This study investigated the potential of a mindfulness-based intervention to reduce cancer-related cognitive impairment (CRCI) in breast cancer survivors. Results showed that all groups reported an improvement in cognitive complaints over time, and both mindfulness-based intervention and physical training can improve psychological well-being of breast cancer survivors with cognitive complaints.
Article
Neurosciences
P. Van Ruitenbeek, T. Santos Monteiro, S. Chalavi, B. R. King, K. Cuypers, S. Sunaert, R. Peeters, S. P. Swinnen
Summary: The study proposes the Compensation Related Utilization of Neural Circuits Hypothesis (CRUNCH) to explain the brain activity changes in healthy aging and task complexity. The findings suggest that all adults show increased brain activation with task complexity, older adults have more brain activation compared to younger adults at low complexity levels, and older adults are able to increase neural resources as task demands increase. These results indicate that older adults exhibit compensatory brain activation and maintain the capacity to adapt to task demands.
Article
Clinical Neurology
Elena M. Bonke, Amanda Clauwaert, Stefan M. Hillmann, Uta Tacke, Caroline Seer, Eukyung Yhang, Yorghos Tripodis, Stian B. Sandmo, Tim L. T. Wiegand, David Kaufmann, Elisabeth Kaufmann, Sutton B. Richmond, Malo Gaubert, Johanna Seitz-Holland, Alexander Leemans, Stephan P. Swinnen, Roald Bahr, Ofer Pasternak, Florian Heinen, Inga K. Koerte, Michaela V. Bonfert, Jolien Gooijers
Summary: This study investigates the relationship between neurological soft signs (NSS) and postural control in adolescent athletes, and suggests that force plate measures can provide relevant quantitative information in addition to qualitative assessments.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Article
Neurosciences
Geraldine Rodriguez-Nieto, Oron Levin, Lize Hermans, Akila Weerasekera, Anca Croitor Sava, Astrid Haghebaert, Astrid Huybrechts, Koen Cuypers, Dante Mantini, Uwe Himmelreich, Stephan P. Swinnen
Summary: Aging is associated with structural and metabolic changes in the brain. Previous research has focused on individual brain regions, but the relationship among metabolites across the brain has been less studied. Using 1H-MRS, this study investigated the relationship among metabolite concentrations in different brain regions in young and older adults. The results showed age-related differences in metabolite concentrations and revealed associative patterns between metabolites across brain regions, which differed between age groups.
Article
Computer Science, Information Systems
Eric Cito Becman, Larissa Driemeier, Oron Levin, Stephan Swinnen, Arturo Forner-Cordero
Summary: This study investigates the impact of training and testing condition differences on the predictions of a convolutional neural network (CNN) for myoelectric simultaneous and proportional control (SPC). A dataset of electromyogram (EMG) signals and joint angular accelerations recorded during a star drawing task was utilized. CNNs were trained using specific combinations of motion amplitude and frequency and tested under different combinations. The predictive performance was evaluated using normalized root mean squared error (NRMSE), correlation, and linear regression slope. The results showed that the predictive performance declined differently depending on the increase or decrease of confounding factors. Correlation decreased as the factors decreased, while slope deteriorated when the factors increased. NRMSE worsened in both increasing and decreasing factor scenarios. The study suggests that differences in EMG signal-to-noise ratio (SNR) between training and testing may affect the noise robustness of the CNNs' learned internal features, leading to worse correlations. Additionally, the inability of the networks to predict accelerations outside the training range may contribute to slope deterioration. These findings provide opportunities for developing strategies to mitigate the negative impact of confounding factors on myoelectric SPC devices.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2023)
Article
Neurosciences
Ahmed Radwan, Lisa Decraene, Patrick Dupont, Nicolas Leenaerts, Cristina Simon-Martinez, Katrijn Klingels, Els Ortibus, Hilde Feys, Stefan Sunaert, Jeroen Blommaert, Lisa Mailleux
Summary: This study explored the structural brain connectomes in children with spastic unilateral cerebral palsy (uCP) and its relationship to sensory-motor function using graph theory. The results showed a hyperconnectivity pattern in the CDGM-lesion group compared to the PWM-lesion group, with higher clustering coefficient, characteristic path length, and local efficiency. The CST-wiring pattern was found to be the strongest predictor for motor function. The findings highlight the potential of structural connectomics in understanding disease severity and brain development in children with uCP.
HUMAN BRAIN MAPPING
(2023)
Article
Physiology
Wilhelmina E. Radstake, Steven Jillings, Steven Laureys, Athena Demertzi, Stefan Sunaert, Angelique Van Ombergen, Floris L. Wuyts
Summary: This study aimed to investigate whether fighter pilots, who are exposed to frequent g-level transitions and high g-levels, show differential functional characteristics compared to matched controls, indicative of neuroplasticity. The results showed altered functional connectivity in the brains of fighter pilots, suggesting adaptive coping strategies to altered sensorimotor demands during flight.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Nastasia Marinus, Veronique Cornelissen, Raf Meesen, Karin Coninx, Dominique Hansen
Summary: This study examines whether exercise prescriptions by physiotherapists to patients with cardiovascular disease are in line with European recommendations. The results show a wide variability in exercise prescriptions among physiotherapists, with many prescriptions not aligning with the recommendations.
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
(2023)
Correction
Multidisciplinary Sciences
Elke Lathouwers, Ahmed Radwan, Jeroen Blommaert, Lara Stas, Bruno Tassignon, Sabine D. Allard, Filip De Ridder, Elisabeth De Waele, Nicole Hoornaert, Patrick Lacor, Rembert Mertens, Maarten Naeyaert, Hubert Raeymaekers, Lucie Seyler, Anne-Marie Vanbinst, Lien Van Liedekerke, Jeroen Van Schependom, Peter Van Schuerbeek, Steven Provyn, Bart Roelands, Marie Vandekerckhove, Romain Meeusen, Stefan Sunaert, Guy Nagels, Johan De Mey, Kevin De Pauw
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Elke Lathouwers, Ahmed Radwan, Jeroen Blommaert, Lara Stas, Bruno Tassignon, Sabine D. Allard, F. De Ridder, E. De Waele, N. Hoornaert, P. Lacor, R. Mertens, Maarten Naeyaert, Hubert Raeymaekers, Lucie Seyler, A. M. Vanbinst, Lien Van Liedekerke, Jeroen Van Schependom, Peter Van Schuerbeek, Steven Provyn, Bart Roelands, Marie Vandekerckhove, R. Meeusen, Stefan Sunaert, G. Nagels, J. De Mey, Kevin De Pauw
Summary: COVID-19 can have negative impacts on the quality of life and induce neurological sequelae. This study reveals differences in structural brain connectivity and cognitive performance between former hospitalised COVID-19 patients and healthy controls.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Michelle Melis, Gwen Schroyen, Jeroen Blommaert, Nicolas Leenaerts, Ann Smeets, Katleen Van Der Gucht, Stefan Sunaert, Sabine Deprez
Summary: Cognitive impairment is a common issue after cancer treatment, and it negatively affects the quality of life for cancer survivors. This study investigated the potential of a mindfulness-based intervention to impact the mechanisms of cancer-related cognitive impairment (CRCI). Breast cancer survivors with cognitive complaints were assigned to a mindfulness, physical training, or waitlist control group. The results showed that physical training had the most pronounced effects on functional network organization and biomarkers of inflammation, which are believed to be involved in CRCI.
Meeting Abstract
Neurosciences
Thomas Vande Casteele, Maarten Laroy, Margot Van Cauwenberge, Michel Koole, Patrick Dupont, Stefan Sunaert, Jan Van den Stock, Filip Bouckaert, Koen Van Laere, Louise Emsell, Mathieu Vandenbulcke
BIOLOGICAL PSYCHIATRY
(2023)
Meeting Abstract
Urology & Nephrology
Anugrah Santoso, Stefan Sunaert, Dirk De Ridder
JOURNAL OF UROLOGY
(2023)
Meeting Abstract
Urology & Nephrology
A. D. Santoso, S. Sunaert, D. De Ridder
