Can MRI measure myelin? Systematic review, qualitative assessment, and meta-analysis of studies validating microstructural imaging with myelin histology

Preservation of a remote fear memory requires new myelin formation

(2020) Simon Pan et al.   NATURE NEUROSCIENCE

Combined Diffusion Tensor Imaging and Quantitative Susceptibility Mapping Discern Discrete Facets of White Matter Pathology Post-injury in the Rodent Brain

(2020) Neha Soni et al.   Frontiers in Neurology

Mapping Human Laryngeal Motor Cortex during Vocalization

(2020) Nicole Eichert et al.   CEREBRAL CORTEX

Multiparameter mapping of relaxation ( R1 , R2 *), proton density and magnetization transfer saturation at 3 T : A multicenter dual‐vendor reproducibility and repeatability study

(2020) Tobias Leutritz et al.   HUMAN BRAIN MAPPING

Myelin plasticity: sculpting circuits in learning and memory

(2020) Wendy Xin et al.   NATURE REVIEWS NEUROSCIENCE

An interactive meta-analysis of MRI biomarkers of myelin

(2020) Matteo Mancini et al.   eLife

Relationship of Iron Metabolism and Short-Term Cuprizone Treatment of C57BL/6 Mice

(2019) Edina Pandur et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Formalin tissue fixation biases myelin‐sensitive MRI

(2019) Alan C. Seifert et al.   MAGNETIC RESONANCE IN MEDICINE

Compulsivity and impulsivity traits linked to attenuated developmental frontostriatal myelination trajectories

(2019) Gabriel Ziegler et al.   NATURE NEUROSCIENCE

Correlative study using structural MRI and super-resolution microscopy to detect structural alterations induced by long-term optogenetic stimulation of striatal medium spiny neurons

(2019) Yoshifumi Abe et al.   NEUROCHEMISTRY INTERNATIONAL

Validating the sensitivity of inhomogeneous magnetization transfer (ihMT) MRI to myelin with fluorescence microscopy

(2019) G. Duhamel et al.   NEUROIMAGE

White matter changes in the perforant path area in patients with amyotrophic lateral sclerosis

(2019) J. Mollink et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Iron, Myelin, and the Brain: Neuroimaging Meets Neurobiology

(2019) Harald E. Möller et al.   TRENDS IN NEUROSCIENCES

Correlations of quantitative MRI metrics with myelin basic protein (MBP) staining in a murine model of demyelination

(2019) Lucas Soustelle et al.   NMR IN BIOMEDICINE

Matching ex vivo MRI With Iron Histology: Pearls and Pitfalls

(2019) Amaury De Barros et al.   Frontiers in Neuroanatomy

White matter mean diffusivity correlates with myelination in tuberous sclerosis complex

(2019) Jurriaan M. Peters et al.   Annals of Clinical and Translational Neurology

Optimization of ultrastructural preservation of human brain for transmission electron microscopy after long post-mortem intervals

(2019) Mariella Sele et al.   Acta Neuropathologica Communications

Disruption of Oligodendrogenesis Impairs Memory Consolidation in Adult Mice

(2019) Patrick E. Steadman et al.   NEURON

Comparing meta-analyses and preregistered multiple-laboratory replication projects

(2019) Amanda Kvarven et al.   Nature Human Behaviour

Molecular composition of the human primary visual cortex profiled by multimodal mass spectrometry imaging

(2018) Estibaliz González de San Román et al.   Brain Structure & Function

A Survey of Methods for 3D Histology Reconstruction

(2018) Jonas Pichat et al.   MEDICAL IMAGE ANALYSIS

Microstructural imaging in the spinal cord and validation strategies

(2018) J. Cohen-Adad   NEUROIMAGE

Microstructural imaging of human neocortex in vivo

(2018) Luke J. Edwards et al.   NEUROIMAGE

Inferring brain tissue composition and microstructure via MR relaxometry

(2018) Mark D. Does   NEUROIMAGE

The influence of brain iron and myelin on magnetic susceptibility and effective transverse relaxation - A biochemical and histological validation study

(2018) Simon Hametner et al.   NEUROIMAGE

Untangling the R2* contrast in multiple sclerosis: A combined MRI-histology study at 7.0 Tesla

(2018) Francesca Bagnato et al.   PLoS One

Test-retest reliability of myelin imaging in the human spinal cord: Measurement errors versus region- and aging-induced variations

(2018) Simon Lévy et al.   PLoS One

Brain region-specific enhancement of remyelination and prevention of demyelination by the CSF1R kinase inhibitor BLZ945

(2018) Nicolau Beckmann et al.   Acta Neuropathologica Communications

Teriflunomide's Effect on Glia in Experimental Demyelinating Disease: A Neuroimaging and Histologic Study

(2018) Suyog Pol et al.   JOURNAL OF NEUROIMAGING

The choice of embedding media affects image quality, tissue R2 * , and susceptibility behaviors in post-mortem brain MR microscopy at 7.0T

(2018) Petr Dusek et al.   MAGNETIC RESONANCE IN MEDICINE

On the scaling behavior of water diffusion in human brain white matter

(2018) Jelle Veraart et al.   NEUROIMAGE

Quantifying brain microstructure with diffusion MRI: Theory and parameter estimation

(2018) Dmitry S. Novikov et al.   NMR IN BIOMEDICINE

Combined fetal inflammation and postnatal hypoxia causes myelin deficits and autism-like behavior in a rat model of diffuse white matter injury

(2017) Erik van Tilborg et al.   GLIA

Sound-Evoked Activity Influences Myelination of Brainstem Axons in the Trapezoid Body

(2017) James L. Sinclair et al.   JOURNAL OF NEUROSCIENCE

On Myelinated Axon Plasticity and Neuronal Circuit Formation and Function

(2017) Rafael G. Almeida et al.   JOURNAL OF NEUROSCIENCE

Accuracy, repeatability, and interplatform reproducibility of T1 quantification methods used for DCE-MRI: Results from a multicenter phantom study

(2017) Octavia Bane et al.   MAGNETIC RESONANCE IN MEDICINE

Best practices in data analysis and sharing in neuroimaging using MRI

(2017) Thomas E Nichols et al.   NATURE NEUROSCIENCE

Quantitative temporal changes in DTI values coupled with histological properties in cuprizone-induced demyelination and remyelination

(2017) Ryutaro Yano et al.   NEUROCHEMISTRY INTERNATIONAL

Validating myelin water imaging with transmission electron microscopy in a rat spinal cord injury model

(2017) Henry Szu-Meng Chen et al.   NEUROIMAGE

The role of myelination in measures of white matter integrity: Combination of diffusion tensor imaging and two-photon microscopy of CLARITY intact brains

(2017) Eric H. Chang et al.   NEUROIMAGE

Promise and pitfalls of g-ratio estimation with MRI

(2017) Jennifer S.W. Campbell et al.   NEUROIMAGE

Decoding the microstructural correlate of diffusion MRI

(2017) Svenja Caspers et al.   NMR IN BIOMEDICINE

Lysophosphatidyl Choline Induced Demyelination in Rat Probed by Relaxation along a Fictitious Field in High Rank Rotating Frame

(2017) Lauri J. Lehto et al.   Frontiers in Neuroscience

Neurite dispersion: a new marker of multiple sclerosis spinal cord pathology?

(2017) Francesco Grussu et al.   Annals of Clinical and Translational Neurology

Histological validation of fast macromolecular proton fraction mapping as a quantitative myelin imaging method in the cuprizone demyelination model

(2017) Marina Yu Khodanovich et al.   Scientific Reports

Radiological-pathological correlation of diffusion tensor and magnetization transfer imaging in a closed head traumatic brain injury model

(2016) Tsang-Wei Tu et al.   ANNALS OF NEUROLOGY

Comparing dependent robust correlations

(2016) Rand R. Wilcox   BRITISH JOURNAL OF MATHEMATICAL & STATISTICAL PSYCHOLOGY

Repair strategies for multiple sclerosis

(2016) Bruno Stankoff et al.   CURRENT OPINION IN NEUROLOGY

Non-parametric combination and related permutation tests for neuroimaging

(2016) Anderson M. Winkler et al.   HUMAN BRAIN MAPPING

Test-retest reliability and concurrent validity of in vivo myelin content indices: Myelin water fraction and calibrated T1 w/T2 w image ratio

(2016) Muzamil Arshad et al.   HUMAN BRAIN MAPPING

Myelination of parvalbumin interneurons: a parsimonious locus of pathophysiological convergence in schizophrenia

(2016) J Stedehouder et al.   MOLECULAR PSYCHIATRY

Temperature dependence of water diffusion pools in brain white matter

(2016) Bibek Dhital et al.   NEUROIMAGE

Myelin volume fraction imaging with MRI

(2016) Kathryn L. West et al.   NEUROIMAGE

Multi-compartment microscopic diffusion imaging

(2016) Enrico Kaden et al.   NEUROIMAGE

In vivo quantification of demyelination and recovery using compartment-specific diffusion MRI metrics validated by electron microscopy

(2016) Ileana O. Jelescu et al.   NEUROIMAGE

Evaluation of diffusion kurtosis imaging in ex vivo hypomyelinated mouse brains

(2016) Nathaniel D. Kelm et al.   NEUROIMAGE

Oligodendroglial NMDA Receptors Regulate Glucose Import and Axonal Energy Metabolism

(2016) Aiman S. Saab et al.   NEURON

Myelin plasticity in the central nervous system

(2016) David Purger et al.   NEUROPHARMACOLOGY

Effects of formalin fixation and temperature on MR relaxation times in the human brain

(2016) Christoph Birkl et al.   NMR IN BIOMEDICINE

Activity-Dependent and Experience-Driven Myelination Provide New Directions for the Management of Multiple Sclerosis

(2016) Samuel K. Jensen et al.   TRENDS IN NEUROSCIENCES

AxonSeg: Open Source Software for Axon and Myelin Segmentation and Morphometric Analysis

(2016) Aldo Zaimi et al.   Frontiers in Neuroinformatics

Differentiation and quantification of inflammation, demyelination and axon injury or loss in multiple sclerosis

(2015) Yong Wang et al.   BRAIN

CombinedEx Vivo9.4T MRI and Quantitative Histopathological Study in Normal and Pathological Neocortical Resections in Focal Epilepsy

(2015) Cheryl Reeves et al.   BRAIN PATHOLOGY

Advances in MRI-based computational neuroanatomy

(2015) Nikolaus Weiskopf et al.   CURRENT OPINION IN NEUROLOGY

Modeling T 1 and T 2 relaxation in bovine white matter

(2015) R. Barta et al.   JOURNAL OF MAGNETIC RESONANCE

MRI relaxation in the presence of fictitious fields correlates with myelin content in normal rat brain

(2015) Hanne Hakkarainen et al.   MAGNETIC RESONANCE IN MEDICINE

Magnetization transfer ratio does not correlate to myelin content in the brain in the MOG-EAE mouse model

(2015) Sveinung Fjær et al.   NEUROCHEMISTRY INTERNATIONAL

Multivariate combination of magnetization transfer, T 2 * and B0 orientation to study the myelo-architecture of the in vivo human cortex

(2015) G. Mangeat et al.   NEUROIMAGE

Quantitative MRI in a non-surgical model of cervical spinal cord injury

(2015) Wendy Oakden et al.   NMR IN BIOMEDICINE

In vivoquantitative magnetization transfer imaging correlates with histology during de- and remyelination in cuprizone-treated mice

(2015) Laura Turati et al.   NMR IN BIOMEDICINE

Histological validation of high-resolution DTI in human post mortem tissue

(2015) Arne Seehaus et al.   Frontiers in Neuroanatomy

The Extent and Consequences of P-Hacking in Science

(2015) Megan L. Head et al.   PLOS BIOLOGY

In vivo longitudinal Myelin Water Imaging in rat spinal cord following dorsal column transection injury

(2014) Piotr Kozlowski et al.   MAGNETIC RESONANCE IMAGING

On the accuracy of T1mapping: Searching for common ground

(2014) Nikola Stikov et al.   MAGNETIC RESONANCE IN MEDICINE

MRI-based myelin water imaging: A technical review

(2014) Eva Alonso-Ortiz et al.   MAGNETIC RESONANCE IN MEDICINE

Widespread age-related differences in the human brain microstructure revealed by quantitative magnetic resonance imaging

(2014) Martina F. Callaghan et al.   NEUROBIOLOGY OF AGING

Myelin and iron concentration in the human brain: A quantitative study of MRI contrast

(2014) Carsten Stüber et al.   NEUROIMAGE

Motor skill learning requires active central myelination

(2014) I. A. McKenzie et al.   SCIENCE

Lifespan maturation and degeneration of human brain white matter

(2014) Jason D. Yeatman et al.   Nature Communications

Iron and neurodegeneration in the multiple sclerosis brain

(2013) Simon Hametner et al.   ANNALS OF NEUROLOGY

Motor Skill Learning Induces Changes in White Matter Microstructure and Myelination

(2013) C. Sampaio-Baptista et al.   JOURNAL OF NEUROSCIENCE

Quantifying the local tissue volume and composition in individual brains with magnetic resonance imaging

(2013) Aviv Mezer et al.   NATURE MEDICINE

Power failure: why small sample size undermines the reliability of neuroscience

(2013) Katherine S. Button et al.   NATURE REVIEWS NEUROSCIENCE

The radial diffusivity and magnetization transfer pool size ratio are sensitive markers for demyelination in a rat model of type III multiple sclerosis (MS) lesions

(2013) Vaibhav A. Janve et al.   NEUROIMAGE

Why diffusion tensor MRI does well only some of the time: Variance and covariance of white matter tissue microstructure attributes in the living human brain

(2013) Silvia De Santis et al.   NEUROIMAGE

What can we learn from T2* maps of the cortex?

(2013) J. Cohen-Adad   NEUROIMAGE

Quantitative magnetic susceptibility of the developing mouse brain reveals microstructural changes in the white matter

(2013) Ioannis Argyridis et al.   NEUROIMAGE

Quantitative MRI and ultrastructural examination of the cuprizone mouse model of demyelination

(2013) Jonathan D. Thiessen et al.   NMR IN BIOMEDICINE

Deep Gray Matter Demyelination Detected by Magnetization Transfer Ratio in the Cuprizone Model

(2013) Sveinung Fjær et al.   PLoS One

Lipidome and proteome map of myelin membranes

(2012) Gopakumar Gopalakrishnan et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Oligodendroglia metabolically support axons and contribute to neurodegeneration

(2012) Youngjin Lee et al.   NATURE

Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity

(2012) Ursula Fünfschilling et al.   NATURE

Plasticity in gray and white: neuroimaging changes in brain structure during learning

(2012) Robert J Zatorre et al.   NATURE NEUROSCIENCE

Impaired adult myelination in the prefrontal cortex of socially isolated mice

(2012) Jia Liu et al.   NATURE NEUROSCIENCE

NODDI: Practical in vivo neurite orientation dispersion and density imaging of the human brain

(2012) Hui Zhang et al.   NEUROIMAGE

A Critical Period for Social Experience-Dependent Oligodendrocyte Maturation and Myelination

(2012) M. Makinodan et al.   SCIENCE

Correlating Quantitative MR Imaging with Histopathology in X-Linked Adrenoleukodystrophy

(2011) J.P. van der Voorn et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Multiple sclerosis normal-appearing white matter: Pathology-imaging correlations

(2011) Natalia M. Moll et al.   ANNALS OF NEUROLOGY

Quantification of increased cellularity during inflammatory demyelination

(2011) Yong Wang et al.   BRAIN

In vivo Magnetization Transfer MRI Shows Dysmyelination in an Ischemic Mouse Model of Periventricular Leukomalacia

(2011) Ali Fatemi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Mapping Human Cortical Areas In Vivo Based on Myelin Content as Revealed by T1- and T2-Weighted MRI

(2011) M. F. Glasser et al.   JOURNAL OF NEUROSCIENCE

In vivo assessment of myelination by phase imaging at high magnetic field

(2011) Gregory A. Lodygensky et al.   NEUROIMAGE

Magnetic resonance imaging and histological evidence for the blockade of cuprizone-induced demyelination in C57BL/6 mice

(2011) P. Chandran et al.   NEUROSCIENCE

Inflammatory Cortical Demyelination in Early Multiple Sclerosis

(2011) Claudia F. Lucchinetti et al.   NEW ENGLAND JOURNAL OF MEDICINE

High field (9.4 Tesla) magnetic resonance imaging of cortical grey matter lesions in multiple sclerosis

(2010) Klaus Schmierer et al.   BRAIN

Behavioural relevance of variation in white matter microstructure

(2010) Heidi Johansen-Berg   CURRENT OPINION IN NEUROLOGY

Changes in Prefrontal Axons May Disrupt the Network in Autism

(2010) B. Zikopoulos et al.   JOURNAL OF NEUROSCIENCE

In Vivo Longitudinal MRI and Behavioral Studies in Experimental Spinal Cord Injury

(2010) Laura M. Sundberg et al.   JOURNAL OF NEUROTRAUMA

Pathological basis of diffusely abnormal white matter: insights from magnetic resonance imaging and histology

(2010) Cornelia Laule et al.   Multiple Sclerosis Journal

Fast bound pool fraction imaging of the in vivo rat brain: Association with myelin content and validation in the C6 glioma model

(2010) Hunter R. Underhill et al.   NEUROIMAGE

Layer-specific variation of iron content in cerebral cortex as a source of MRI contrast

(2010) Masaki Fukunaga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mild Hypoxic-Ischemic Injury in the Neonatal Rat Brain: Longitudinal Evaluation of White Matter Using Diffusion Tensor MR Imaging

(2009) S. Wang et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Diffusely Abnormal White Matter in Chronic Multiple Sclerosis

(2009) Alexandra Seewann et al.   ARCHIVES OF NEUROLOGY

Characterizing healthy and diseased white matter using quantitative magnetization transfer and multicomponentT2relaxometry: A unified view via a four-pool model

(2009) Ives R. Levesque et al.   MAGNETIC RESONANCE IN MEDICINE

Postmortem MRI of human brain hemispheres:T2relaxation times during formaldehyde fixation

(2009) Robert J. Dawe et al.   MAGNETIC RESONANCE IN MEDICINE

Aldehyde fixative solutions alter the water relaxation and diffusion properties of nervous tissue

(2009) Timothy M. Shepherd et al.   MAGNETIC RESONANCE IN MEDICINE

Neurite density from magnetic resonance diffusion measurements at ultrahigh field: Comparison with light microscopy and electron microscopy

(2009) Sune N. Jespersen et al.   NEUROIMAGE

A defect of sphingolipid metabolism modifies the properties of normal appearing white matter in multiple sclerosis

(2008) David Wheeler et al.   BRAIN

Introducing Black-Gold II, a highly soluble gold phosphate complex with several unique advantages for the histochemical localization of myelin

(2008) Larry Schmued et al.   BRAIN RESEARCH

A correlative light and electron microscopic study of postnatal myelination in the murine corpus callosum

(2008) András Vincze et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Maturational changes in diffusion anisotropy in the rat corpus callosum: Comparison with quantitative histological evaluation

(2008) Junya Jito et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Characterizing White Matter Damage in Rat Spinal Cord with Quantitative MRI and Histology

(2008) Piotr Kozlowski et al.   JOURNAL OF NEUROTRAUMA

Quantitative magnetic resonance of postmortem multiple sclerosis brain before and after fixation

(2008) Klaus Schmierer et al.   MAGNETIC RESONANCE IN MEDICINE

Visualization of peripheral nerve degeneration and regeneration: Monitoring with diffusion tensor tractography

(2008) Takehiko Takagi et al.   NEUROIMAGE

MR Relaxation in Multiple Sclerosis

(2008) A.L. MacKay et al.   NEUROIMAGING CLINICS OF NORTH AMERICA

Complementary information from multi-exponential T2 relaxation and diffusion tensor imaging reveals differences between multiple sclerosis lesions

(2007) Shannon H. Kolind et al.   NEUROIMAGE

Myelin water imaging of multiple sclerosis at 7 T: Correlations with histopathology

(2007) Cornelia Laule et al.   NEUROIMAGE