Präklinische Modelle für Kopf-Hals-Tumoren

Short-term culture of tumour slices reveals the heterogeneous sensitivity of human head and neck squamous cell carcinoma to targeted therapies

(2016) Jérôme Donnadieu et al.   BMC CANCER

Targeting irradiation-induced mitogen-activated protein kinase activation in vitro and in an ex vivo model for human head and neck cancer

(2016) Annette Affolter et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Studienergebnisse zur Primärtherapie von Kopf-Hals-Tumoren

(2016) A. Gliese et al.   HNO

Präklinische Modelle zur Etablierung innovativer Therapiestrategien

(2016) G. Wichmann et al.   HNO

Immuntherapeutische Studien bei Kopf-Hals-Tumoren

(2016) C.-J. Busch et al.   HNO

Cetuximab and Radiotherapy Versus Cisplatin and Radiotherapy for Locally Advanced Head and Neck Cancer: A Randomized Phase II Trial

(2016) Stefano Maria Magrini et al.   JOURNAL OF CLINICAL ONCOLOGY

Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): an open-label, multicentre, phase 1b trial

(2016) Tanguy Y Seiwert et al.   LANCET ONCOLOGY

Maintaining Tumor Heterogeneity in Patient-Derived Tumor Xenografts

(2015) J. W. Cassidy et al.   CANCER RESEARCH

Radiation Enhancement of Head and Neck Squamous Cell Carcinoma by the Dual PI3K/mTOR Inhibitor PF-05212384

(2015) A. J. Leiker et al.   CLINICAL CANCER RESEARCH

Taselisib (GDC-0032), a Potent  -Sparing Small Molecule Inhibitor of PI3K, Radiosensitizes Head and Neck Squamous Carcinomas Containing Activating PIK3CA Alterations

(2015) Z. S. Zumsteg et al.   CLINICAL CANCER RESEARCH

Evaluation of individual sensitivity of head and neck squamous cell carcinoma to cetuximab by short-term culture of tumor slices

(2015) Marine Peria et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications

(2015) Francesco Perri et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Immuntherapie von Kopf-Hals-Karzinomen

(2015) S. Laban et al.   HNO

Therapie der rezidivierten und fernmetastasierten Plattenepithelkarzinome des Kopf-Hals-Bereichs

(2015) L. Bußmann et al.   HNO

Die wichtigsten Studienergebnisse zur nichtchirurgischen Primärtherapie lokal fortgeschrittener Kopf‑Hals‑Tumoren

(2015) A. Gliese et al.   HNO

Current Treatment Options for Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

(2015) Assuntina G. Sacco et al.   JOURNAL OF CLINICAL ONCOLOGY

Proteomic Characterization of Head and Neck Cancer Patient-Derived Xenografts

(2015) H. Li et al.   MOLECULAR CANCER RESEARCH

XactMice: humanizing mouse bone marrow enables microenvironment reconstitution in a patient-derived xenograft model of head and neck cancer

(2015) J J Morton et al.   ONCOGENE

Spherical Cancer Models in Tumor Biology

(2015) Louis-Bastien Weiswald et al.   NEOPLASIA

Feasibility of Primary Tumor Culture Models and Preclinical Prediction Assays for Head and Neck Cancer: A Narrative Review

(2015) Amy Dohmen et al.   Cancers

Lessons from patient-derived xenografts for better in vitro modeling of human cancer

(2014) Stephen Yiu Chuen Choi et al.   ADVANCED DRUG DELIVERY REVIEWS

Three-dimensional models of cancer for pharmacology and cancer cell biology: Capturing tumor complexity in vitro/ex vivo

(2014) John A. Hickman et al.   Biotechnology Journal

Phosphorylation of AKT(Ser473) serves as an independent prognostic marker for radiosensitivity in advanced head and neck squamous cell carcinoma

(2014) Christian Freudlsperger et al.   INTERNATIONAL JOURNAL OF CANCER

A comprehensively characterized large panel of head and neck cancer patient-derived xenografts identifies the mTOR inhibitor everolimus as potential new treatment option

(2014) Konrad Klinghammer et al.   INTERNATIONAL JOURNAL OF CANCER

Genomic Analysis of Head and Neck Squamous Cell Carcinoma Cell Lines and Human Tumors: A Rational Approach to Preclinical Model Selection

(2014) Hua Li et al.   MOLECULAR CANCER RESEARCH

Slice cultures from head and neck squamous cell carcinoma: a novel test system for drug susceptibility and mechanisms of resistance

(2013) M M Gerlach et al.   BRITISH JOURNAL OF CANCER

Characterization of squamous cell carcinoma in an organotypic culture via subsurface non-linear optical molecular imaging

(2013) Christina S Scanlon et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Tumor grafts derived from patients with head and neck squamous carcinoma authentically maintain the molecular and histologic characteristics of human cancers

(2013) Shaohua Peng et al.   Journal of Translational Medicine

Exploiting the Head and Neck Cancer Oncogenome: Widespread PI3K-mTOR Pathway Alterations and Novel Molecular Targets

(2013) R. Iglesias-Bartolome et al.   Cancer Discovery

The molecular pathogenesis of head and neck squamous cell carcinoma

(2012) S. Michael Rothenberg et al.   JOURNAL OF CLINICAL INVESTIGATION

Long-Term Results of RTOG 91-11: A Comparison of Three Nonsurgical Treatment Strategies to Preserve the Larynx in Patients With Locally Advanced Larynx Cancer

(2012) Arlene A. Forastiere et al.   JOURNAL OF CLINICAL ONCOLOGY

Patient-derived tumour xenografts as models for oncology drug development

(2012) John J. Tentler et al.   Nature Reviews Clinical Oncology

Integrating Macrophages into Organotypic Co-Cultures: A 3D In Vitro Model to Study Tumor-Associated Macrophages

(2012) Nina Linde et al.   PLoS One

Development of tissue-engineered models of oral dysplasia and early invasive oral squamous cell carcinoma

(2011) H E Colley et al.   BRITISH JOURNAL OF CANCER

Evidence for Epithelial-Mesenchymal Transition in Cancer Stem Cells of Head and Neck Squamous Cell Carcinoma

(2011) Chao Chen et al.   PLoS One

Pro-survival AKT and ERK signaling from EGFR and mutant EGFRvIII enhances DNA double-strand break repair in human glioma cells

(2010) Sarah E. Golding et al.   CANCER BIOLOGY & THERAPY

Activation of mitogen-activated protein kinase extracellular signal-related kinase in head and neck squamous cell carcinomas after irradiation as part of a rescue mechanism

(2010) Annette Affolter et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

A Primary Xenograft Model of Small-Cell Lung Cancer Reveals Irreversible Changes in Gene Expression Imposed by Culture In vitro

(2009) V. C. Daniel et al.   CANCER RESEARCH

In vitro and In vivo Radiosensitization with AZD6244 (ARRY-142886), an Inhibitor of Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase 1/2 Kinase

(2009) E. J. Chung et al.   CLINICAL CANCER RESEARCH

A novel mechanism for anti-EGFR antibody action involves chemokine-mediated leukocyte infiltration

(2009) Thomas K. Hoffmann et al.   INTERNATIONAL JOURNAL OF CANCER

Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival

(2009) James A Bonner et al.   LANCET ONCOLOGY

From Human to Mouse and Back: 'Tumorgraft' Models Surge in Popularity

(2008) K. Garber   JNCI-Journal of the National Cancer Institute

Fibroblast growth factor receptor-mediated signals contribute to the malignant phenotype of non-small cell lung cancer cells: therapeutic implications and synergism with epidermal growth factor receptor inhibition

(2008) Hendrik Fischer et al.   MOLECULAR CANCER THERAPEUTICS

Platinum-Based Chemotherapy plus Cetuximab in Head and Neck Cancer

(2008) Jan B. Vermorken et al.   NEW ENGLAND JOURNAL OF MEDICINE

Co-culture of Head and Neck Squamous Cell Carcinoma Spheroids with Autologous Monocytes Predicts Prognosis

(2008) K. W. Kross et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY