Mutually exclusive extracellular signal-regulated kinase pathway mutations are present in different stages of multi-focal pulmonary Langerhans cell histiocytosis supporting clonal nature of the disease

Common cancer-associated PIK3CA activating mutations rarely occur in Langerhans cell histiocytosis

(2015) S. Heritier et al.   BLOOD

MAP2K1andMAP3K1mutations in langerhans cell histiocytosis

(2015) David S. Nelson et al.   GENES CHROMOSOMES & CANCER

BRAF V600E Expression in Langerhans Cell Histiocytosis

(2014) Anja C. Roden et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Somatic activating ARAF mutations in Langerhans cell histiocytosis

(2014) D. S. Nelson et al.   BLOOD

High prevalence of somatic MAP2K1 mutations in BRAF V600E-negative Langerhans cell histiocytosis

(2014) N. A. Brown et al.   BLOOD

Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis

(2014) R. Chakraborty et al.   BLOOD

ERK Mutations Confer Resistance to Mitogen-Activated Protein Kinase Pathway Inhibitors

(2014) E. M. Goetz et al.   CANCER RESEARCH

BRAF/KRAS gene sequencing of sebaceous neoplasms after mismatch repair protein analysis

(2014) Kristine M. Cornejo et al.   HUMAN PATHOLOGY

Pulmonary Langerhans Cell Histiocytosis

(2013) Samuel A. Yousem et al.   CHEST

Clonal Status and Clinicopathological Features of Langerhans Cell Histiocytosis

(2013) L Gong et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

High prevalence of MAP2K1 mutations in variant and IGHV4-34–expressing hairy-cell leukemias

(2013) Joshua J Waterfall et al.   NATURE GENETICS

Dramatic efficacy of vemurafenib in both multisystemic and refractory Erdheim-Chester disease and Langerhans cell histiocytosis harboring the BRAF V600E mutation

(2012) J. Haroche et al.   BLOOD

Pulmonary langerhans cell histiocytosis

(2012) Harpreet S Suri et al.   Orphanet Journal of Rare Diseases

Immunohistochemical testing of BRAF V600E status in 1,120 tumor tissue samples of patients with brain metastases

(2011) David Capper et al.   ACTA NEUROPATHOLOGICA

Langerhans cell histiocytosis and Erdheim–Chester disease

(2011) Marta Wilejto et al.   CURRENT OPINION IN RHEUMATOLOGY

Recurrent BRAF mutations in Langerhans cell histiocytosis

(2010) G. Badalian-Very et al.   BLOOD

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

(2010) S. A. Forbes et al.   NUCLEIC ACIDS RESEARCH

Histiocytic Disorders: Recent Insights into Pathophysiology and Practical Guidelines

(2009) Alexandra Filipovich et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

MEK1 mutations confer resistance to MEK and B-RAF inhibition

(2009) C. M. Emery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Noonan, Costello and cardio–facio–cutaneous syndromes: dysregulation of the Ras–MAPK pathway

(2008) William E. Tidyman et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

No genomic aberrations in Langerhans cell histiocytosis as assessed by diverse molecular technologies

(2008) Cristiana E. T. da Costa et al.   GENES CHROMOSOMES & CANCER

The RAS/MAPK syndromes: novel roles of the RAS pathway in human genetic disorders

(2008) Yoko Aoki et al.   HUMAN MUTATION