Angiopoietin-like protein 1 antagonizes MET receptor activity to repress sorafenib resistance and cancer stemness in hepatocellular carcinoma

Cancer statistics, 2015

(2015) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Expression of pERK and VEGFR-2 in advanced hepatocellular carcinoma and resistance to sorafenib treatment

(2015) Francesca V. Negri et al.   LIVER INTERNATIONAL

Thirty Years of Research on Met Receptor to Move a Biomarker from Bench to Bedside

(2014) A. Furlan et al.   CANCER RESEARCH

Cabozantinib Suppresses Tumor Growth and Metastasis in Hepatocellular Carcinoma by a Dual Blockade of VEGFR2 and MET

(2014) Q. Xiang et al.   CLINICAL CANCER RESEARCH

Label-retaining liver cancer cells are relatively resistant to sorafenib

(2013) Hong-Wu Xin et al.   GUT

αB-crystallin complexes with 14-3-3ζ to induce epithelial-mesenchymal transition and resistance to sorafenib in hepatocellular carcinoma

(2013) Xiao-Yong Huang et al.   HEPATOLOGY

MicroRNA-216a/217-induced epithelial-mesenchymal transition targets PTEN and SMAD7 to promote drug resistance and recurrence of liver cancer

(2013) Hongping Xia et al.   HEPATOLOGY

Leukocyte cell-derived chemotaxin 2 antagonizes MET receptor activation to suppress hepatocellular carcinoma vascular invasion by protein tyrosine phosphatase 1B recruitment

(2013) Chi-Kuan Chen et al.   HEPATOLOGY

Angiopoietin-like protein 1 suppresses SLUG to inhibit cancer cell motility

(2013) Tsang-Chih Kuo et al.   JOURNAL OF CLINICAL INVESTIGATION

Cancer stem cells in the development of liver cancer

(2013) Taro Yamashita et al.   JOURNAL OF CLINICAL INVESTIGATION

Met as a therapeutic target in HCC: Facts and hopes

(2013) Silvia Giordano et al.   JOURNAL OF HEPATOLOGY

The Enhanced Metastatic Potential of Hepatocellular Carcinoma (HCC) Cells with Sorafenib Resistance

(2013) Ariel Ka-Man Chow et al.   PLoS One

Long-term exposure to sorafenib of liver cancer cells induces resistance with epithelial-to-mesenchymal transition, increased invasion and risk of rebound growth

(2012) Hannah van Malenstein et al.   CANCER LETTERS

Fas Ligand Enhances Malignant Behavior of Tumor Cells through Interaction with Met, Hepatocyte Growth Factor Receptor, in Lipid Rafts

(2012) Huan-Ching Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tivantinib for second-line treatment of advanced hepatocellular carcinoma: a randomised, placebo-controlled phase 2 study

(2012) Armando Santoro et al.   LANCET ONCOLOGY

Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development

(2012) Junke Zheng et al.   NATURE

Egr-1 mediates epidermal growth factor-induced downregulation of E-cadherin expression via Slug in human ovarian cancer cells

(2012) J-C Cheng et al.   ONCOGENE

Comparison of tumor response by Response Evaluation Criteria in Solid Tumors (RECIST) and modified RECIST in patients treated with sorafenib for hepatocellular carcinoma

(2011) Julien Edeline et al.   CANCER

Angiopoietin-like 4 Protein Elevates the Prosurvival Intracellular O2−:H2O2 Ratio and Confers Anoikis Resistance to Tumors

(2011) Pengcheng Zhu et al.   CANCER CELL

Combining Clinical, Pathology, and Gene Expression Data to Predict Recurrence of Hepatocellular Carcinoma

(2011) Augusto Villanueva et al.   GASTROENTEROLOGY

Hypoxia-inducible factor 1 alpha-activated angiopoietin-like protein 4 contributes to tumor metastasis via vascular cell adhesion molecule-1/integrin β1 signaling in human hepatocellular carcinoma

(2011) Hong Li et al.   HEPATOLOGY

Activation of Phosphatidylinositol 3-Kinase/Akt Signaling Pathway Mediates Acquired Resistance to Sorafenib in Hepatocellular Carcinoma Cells

(2011) K.-F. Chen et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Interactions between cancer stem cells and their niche govern metastatic colonization

(2011) Ilaria Malanchi et al.   NATURE

Twist expression promotes migration and invasion in hepatocellular carcinoma

(2009) Noriyuki Matsuo et al.   BMC CANCER

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Angiopoietin-like Protein 2 Promotes Chronic Adipose Tissue Inflammation and Obesity-Related Systemic Insulin Resistance

(2009) Mitsuhisa Tabata et al.   Cell Metabolism

Comprehensive analysis of the independent effect of twist and snail in promoting metastasis of hepatocellular carcinoma

(2009) Muh-Hwa Yang et al.   HEPATOLOGY

Diagnosis and Treatment of Hepatocellular Carcinoma

(2008) Hashem B. El-Serag et al.   GASTROENTEROLOGY

Sorafenib in Advanced Hepatocellular Carcinoma

(2008) Josep M. Llovet et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hepatocyte growth factor and Met in tumor biology and therapeutic approach with NK4

(2008) Kunio Matsumoto et al.   PROTEOMICS

The Role of Angiopoietin-Like Proteins in Angiogenesis and Metabolism

(2008) Tai Hato et al.   TRENDS IN CARDIOVASCULAR MEDICINE