Prostaglandin E2promotes hepatic bile acid synthesis by an E prostanoid receptor 3-mediated hepatocyte nuclear receptor 4α/cholesterol 7α-hydroxylase pathway in mice

Loss of Function of GALNT2 Lowers High-Density Lipoproteins in Humans, Nonhuman Primates, and Rodents

(2016) Sumeet A. Khetarpal et al.   Cell Metabolism

The PGE2EP3 Receptor Regulates Diet-Induced Adiposity in Male Mice

(2016) Ryan P. Ceddia et al.   ENDOCRINOLOGY

Farnesoid X receptor activation increases reverse cholesterol transport by modulating bile acid composition and cholesterol absorption in mice

(2016) Yang Xu et al.   HEPATOLOGY

EP3 receptor deficiency attenuates pulmonary hypertension through suppression of Rho/TGF-β1 signaling

(2015) Ankang Lu et al.   JOURNAL OF CLINICAL INVESTIGATION

The receptor EP3 to PGE2: A rational target to prevent atherothrombosis without inducing bleeding

(2015) Marie-Anne Mawhin et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus

(2015) Daqian Xu et al.   Nature Communications

The Arachidonic Acid Metabolome Serves as a Conserved Regulator of Cholesterol Metabolism

(2014) Egon Demetz et al.   Cell Metabolism

Cytoplasmic Tyrosine Phosphatase Shp2 Coordinates Hepatic Regulation of Bile Acid and FGF15/19 Signaling to Repress Bile Acid Synthesis

(2014) Shuangwei Li et al.   Cell Metabolism

I Prostanoid Receptor-Mediated Inflammatory Pathway Promotes Hepatic Gluconeogenesis Through Activation of PKA and Inhibition of AKT

(2014) S. Yan et al.   DIABETES

Blocking the EP3 receptor for PGE2 with DG-041 decreases thrombosis without impairing haemostatic competence

(2013) Peggy Tilly et al.   CARDIOVASCULAR RESEARCH

Cyclooxygenase-2–Derived Prostaglandin E 2 Promotes Injury-Induced Vascular Neointimal Hyperplasia Through the E-prostanoid 3 Receptor

(2013) Jian Zhang et al.   CIRCULATION RESEARCH

Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice

(2012) Bo Kong et al.   HEPATOLOGY

Disruption of the 5-lipoxygenase pathway attenuates atherogenesis consequent to COX-2 deletion in mice

(2012) Z. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prostaglandins and Inflammation

(2011) Emanuela Ricciotti et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Celecoxib, a selective cyclooxygenase-2 inhibitor, lowers plasma cholesterol and attenuates hepatic lipid peroxidation during carbon-tetrachloride–associated hepatotoxicity in rats

(2011) Martins Ekor et al.   DRUG AND CHEMICAL TOXICOLOGY

Liver receptor homolog-1 is critical for adequate up-regulation of Cyp7a1 gene transcription and bile salt synthesis during bile salt sequestration

(2011) Carolien Out et al.   HEPATOLOGY

Inflammatory stress exacerbates hepatic cholesterol accumulation via increasing cholesterol uptake and de novo synthesis

(2011) Lei Zhao et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Emotion Recollected in Tranquility: Lessons Learned from the COX-2 Saga

(2010) Tilo Grosser et al.   Annual Review of Medicine

The acute phase response inhibits reverse cholesterol transport

(2010) Kenneth R. Feingold et al.   JOURNAL OF LIPID RESEARCH

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Prostaglandin F2  elevates blood pressure and promotes atherosclerosis

(2009) Y. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased Inflammatory Gene Expression in ABC Transporter–Deficient Macrophages

(2008) Laurent Yvan-Charvet et al.   CIRCULATION

Prostaglandin E2Via Steroidogenic Factor-1 Coordinately Regulates Transcription of Steroidogenic Genes Necessary for Estrogen Synthesis in Endometriosis

(2008) Erkut Attar et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Cellular cholesterol trafficking and compartmentalization

(2008) Elina Ikonen   NATURE REVIEWS MOLECULAR CELL BIOLOGY