Article
Clinical Neurology
Brian Fiani, Juliana Runnels, James Brazdzionis, Dan Miulli
Summary: Intracranial germ cell tumors are rare and can present with a variety of symptoms. Rarely, these tumors can transform into alternative malignancies, leading to challenging treatment options. This article reports a rare case of metastatic adenosquamous carcinoma transformed from a yolk sac tumor in atypical locations of the brain.
ACTA NEUROCHIRURGICA
(2022)
Review
Medical Laboratory Technology
Preetha Ramalingam
Summary: Ovarian germ cell tumors are a diverse group of neoplasms that can be either benign or malignant and occur in a wide age range, with a preference for younger age group. Diagnosis can sometimes be challenging due to overlapping morphology with other tumors, but immunohistochemical stains can help facilitate the correct diagnosis. This review article discusses the clinicopathologic findings and relevant studies of both common and uncommon germ cell tumors of the ovary.
SEMINARS IN DIAGNOSTIC PATHOLOGY
(2023)
Article
Pathology
Khaleel Al-Obaidy, Sean R. Williamson, Nathan Shelman, Muhammad T. Idrees, Thomas M. Ulbright
Summary: Rare hepatoid teratomas (HTs) in testicular germ cell tumor patients present distinct histological features and immunohistochemical profiles compared to hepatoid yolk sac tumor (HYST) and hepatocellular carcinoma (HCC).
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Margaretha A. Skowron, Mara Kotthoff, Felix Bremmer, Katja Ruhnke, Fatma Parmaksiz, Annika Richter, Stefan Kueffer, Kirsten Reuter-Jessen, Stella Pauls, Anja Stefanski, Philipp Stroebel, Kai Stuehler, Daniel Nettersheim
Summary: This study identified a novel CLDN6-ADC for targeting germ cell tumors (GCT) and discovered pharmacological inhibitors that block FGF, VGF, PDGF, mTOR, CHEK1, AURKA, or PARP signaling for the treatment of refractory yolk-sac tumors (YST). Furthermore, the study shed light on the mechanisms of therapy resistance in YST.
MOLECULAR MEDICINE
(2023)
Article
Pathology
Yan Zhou, Aimi Rothrock, Paari Murugan, Faqian Li, Lihong Bu
Summary: PRAME preferentially expresses in pure seminomas or the seminomatous component of mixed GCT, making it a potential diagnostic marker for seminomas.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2022)
Article
Pathology
Yao Li, Xiang Huang, Xue Meng, Yuqing Luo, Shuai Luo, Jinjing Wang
Summary: This report presents a rare case of primary mixed extragonadal germ cell tumor in the shoulder. The patient underwent surgery and chemotherapy, and showed no signs of recurrence during follow-up. The importance of further research on this rare disease to develop effective treatment strategies is emphasized.
DIAGNOSTIC PATHOLOGY
(2023)
Article
Medicine, General & Internal
Shih-Hsiang Chen, Chia-Jui Du, Jin-Yao Lai, Tsung-Yen Chang, Chao-Ping Yang, Iou-Jih Hung, Tang-Her Jaing, Yung-Ching Ming, Chuen Hsueh
Summary: This study analyzed data from 15 children with malignant sacrococcygeal germ cell tumors (MSGCTs) in Taiwan. Some patients were found to have sacrococcygeal tumors present at birth. All patients presented with a bulging mass at the buttock region and normal alpha-fetoprotein levels. The main treatment approach was primary excision of the tumor.
Article
Pathology
Andres M. Acosta, Khaleel Al-Obaidy, Lynette M. Sholl, Brendan C. Dickson, Neal Lindeman, Michelle S. Hirsch, Katrina Collins, Christopher D. Fletcher, Muhammad T. Idrees
Summary: This study found that 60% of SYST tumors in TGCTs carry rare somatic oncogenic mutations, and the presence of these mutations is associated with aggressive clinical progression. High-grade SYST tumors have a higher risk of disease-specific death compared to low-grade tumors, and the presence of somatic mutations increases the risk of disease-specific mortality.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2022)
Review
Medicine, General & Internal
Taiki Isaji, Kenichiro Iwami, Fuminori Ato, Tadashi Watanabe, Emiko Takahashi, Shigeru Miyachi
Summary: Yolk sac tumor (YST) is a rare brain tumor that mainly affects patients under 30 years old, with the most common sites being the pineal and suprasellar regions. YSTs in the medulla oblongata are extremely rare and can be difficult to diagnose due to their uncommon growth patterns. They have a poor prognosis, but this case study presents a 50-year-old woman who remained tumor-free during an 18-month follow-up.
Article
Medical Laboratory Technology
Kenneth A. Iczkowski
Summary: Germ cell neoplasia in situ (GCNIS) is the precursor of both seminomatous and non-seminomatous germ cell tumors. It consists of distended tubules that may have either intratubular seminoma or intratubular embryonal carcinoma cells. The classification of tumor types and the use of immunostains for diagnosis are reviewed. Changes in classification in the AJCC (8th edition) in 2016 are discussed, and other differential diagnoses for germ cell neoplasms are mentioned.
SEMINARS IN DIAGNOSTIC PATHOLOGY
(2023)
Review
Pathology
Vladimir Samal, Tomas Jirasek, Vit Paldus, Igor Richter, Ondrej Hes
Summary: This case report presents a rare case of urachal yolk sac tumor with glandular and hepatoid structures in a male patient presenting with macroscopic hematuria. Immunohistochemistry confirmed the presence of these structures, supporting the diagnosis.
DIAGNOSTIC PATHOLOGY
(2022)
Article
Oncology
Dimitrios Nasioudis, Melissa K. Frey, Eloise Chapman-Davis, Thomas A. Caputo, Kevin M. Holcomb
Summary: A surveillance only strategy for patients with stage I malignant ovarian germ cell tumors is associated with excellent survival outcomes for patients with grade 2 or 3 immature teratoma or mixed germ cell tumors. Patients with yolk sac tumors who received chemotherapy had better overall survival compared to those who did not receive chemotherapy.
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
(2021)
Article
Cell Biology
Felix Bremmer, Lena Lubk, Philipp Stroebel, Daniel Nettersheim
Summary: Testicular germ cell tumours are common malignancies in young men. They are thought to arise from a defective germ cell development. This study found evidence of a subpopulation of yolk-sac tumour cells in seminomas, which may contribute to the aggressive nature of the tumour. The findings suggest the need for an adjustment in therapeutic approach and the inclusion of FOXA2 detection in the diagnosis of seminomas.
Editorial Material
Critical Care Medicine
Eline G. M. Steenhuis, Maaike M. Brus, Nils A. 't Hart, Liudmila L. Kodach, Jacqueline Nijboer-Oosterveld, Benjamin Tomlow
Summary: A 20-year-old woman presented with dry cough, right-sided thoracic pain, and gradually progressive dyspnea on exertion. Laboratory testing showed significantly increased levels of D-dimer and lactate dehydrogenase, as well as elevated C-reactive protein.
Review
Oncology
Xiaochen Yang, Yubo Wang, Geng Chen, Xinyu Hong
Summary: This report presents a case of multifocal primary intracranial yolk sac tumor in an adult patient. The patient underwent surgery and received whole-brain radiotherapy, but unfortunately succumbed to the disease 11 months after the operation.
TRANSLATIONAL CANCER RESEARCH
(2022)