Cardiovascular risk stratification in familial hypercholesterolaemia

Inhibition of PCSK9 with evolocumab in homozygous familial hypercholesterolaemia (TESLA Part B): a randomised, double-blind, placebo-controlled trial

(2015) Frederick J Raal et al.   LANCET

PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled trial

(2015) Frederick J Raal et al.   LANCET

Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society

(2014) M. Cuchel et al.   EUROPEAN HEART JOURNAL

Identifying genetic risk variants for coronary heart disease in familial hypercholesterolemia: an extreme genetics approach

(2014) Jorie Versmissen et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Ten-Year Follow-up After Initiation of Statin Therapy in Children With Familial Hypercholesterolemia

(2014) D. Meeike Kusters et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Carotid Plaque Burden as a Measure of Subclinical Coronary Artery Disease in Patients With Heterozygous Familial Hypercholesterolemia

(2013) Gerrit L. ten Kate et al.   AMERICAN JOURNAL OF CARDIOLOGY

Coronary Computed Tomographic Angiographic Findings in Asymptomatic Patients With Heterozygous Familial Hypercholesterolemia and Null Allele Low-Density Lipoprotein Receptor Mutations

(2013) David Viladés Medel et al.   AMERICAN JOURNAL OF CARDIOLOGY

The effect of LDLR-negative genotype on CT coronary atherosclerosis in asymptomatic statin treated patients with heterozygous familial hypercholesterolemia

(2013) Gert-Jan R. ten Kate et al.   ATHEROSCLEROSIS

Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: Consensus Statement of the European Atherosclerosis Society

(2013) B. G. Nordestgaard et al.   EUROPEAN HEART JOURNAL

Use of low-density lipoprotein cholesterol gene score to distinguish patients with polygenic and monogenic familial hypercholesterolaemia: a case-control study

(2013) Philippa J Talmud et al.   LANCET

Detection of subclinical atherosclerosis in familial hypercholesterolemia using non-invasive imaging modalities

(2012) Paloma Caballero et al.   ATHEROSCLEROSIS

European Guidelines on cardiovascular disease prevention in clinical practice (version 2012)

(2012) Joep Perk et al.   ATHEROSCLEROSIS

Homozygous familial hypercholesterolemia: Current perspectives on diagnosis and treatment

(2012) Frederick J. Raal et al.   ATHEROSCLEROSIS

Statin treatment of children with familial hypercholesterolemia – Trying to balance incomplete evidence of long-term safety and clinical accountability: Are we approaching a consensus?

(2012) Alpo Vuorio et al.   ATHEROSCLEROSIS

European Guidelines on cardiovascular disease prevention in clinical practice (version 2012): The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts) * Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR)

(2012) et al.   EUROPEAN HEART JOURNAL

Common Carotid Intima-Media Thickness Measurements in Cardiovascular Risk Prediction

(2012) Hester M. Den Ruijter et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Familial Hypercholesterolemia in the Danish General Population: Prevalence, Coronary Artery Disease, and Cholesterol-Lowering Medication

(2012) Marianne Benn et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Measurements of Carotid Intima-Media Thickness and of Interadventitia Common Carotid Diameter Improve Prediction of Cardiovascular Events

(2012) Damiano Baldassarre et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Lipoprotein(a) levels in coronary heart disease-susceptible and -resistant patients with familial hypercholesterolemia

(2011) Marit S. Nenseter et al.   ATHEROSCLEROSIS

Accelerated subclinical coronary atherosclerosis in patients with familial hypercholesterolemia

(2011) Lisan A. Neefjes et al.   ATHEROSCLEROSIS

CT coronary plaque burden in asymptomatic patients with familial hypercholesterolaemia

(2011) L. A. Neefjes et al.   HEART

Grosor íntima-media carotídeo en sujetos sin factores de riesgo cardiovascular

(2011) Estíbaliz Jarauta et al.   REVISTA ESPANOLA DE CARDIOLOGIA

Evaluation of subclinical atherosclerosis by computed tomography coronary angiography and its association with risk factors in familial hypercholesterolemia

(2010) Marcio H. Miname et al.   ATHEROSCLEROSIS

Lipoprotein(a) as a cardiovascular risk factor: current status

(2010) Børge G. Nordestgaard et al.   EUROPEAN HEART JOURNAL

Sudden Death in a 4-Year-Old Boy: A Near-Complete Occlusion of the Coronary Artery Caused by an Aggressive Low-Density Lipoprotein Receptor Mutation (W556R) in Homozygous Familial Hypercholesterolemia

(2010) Kurt Widhalm et al.   JOURNAL OF PEDIATRICS

Endothelial activation, inflammation and premature atherosclerosis in children with familial dyslipidemia

(2009) Ornella Guardamagna et al.   ATHEROSCLEROSIS

Impact of low-density lipoprotein receptor mutational class on carotid atherosclerosis in patients with familial hypercholesterolemia

(2009) Mireia Junyent et al.   ATHEROSCLEROSIS

Mutation detection rate and spectrum in familial hypercholesterolaemia patients in the UK pilot cascade project

(2009) A Taylor et al.   CLINICAL GENETICS

Effect of rosuvastatin therapy on carotid plaque morphology and composition in moderately hypercholesterolemic patients: A high-resolution magnetic resonance imaging trial

(2008) Hunter R. Underhill et al.   AMERICAN HEART JOURNAL

No correlation and low agreement of imaging and inflammatory atherosclerosis’ markers in familial hypercholesterolemia

(2008) Lilton R.C. Martinez et al.   ATHEROSCLEROSIS

Development of sensitive and specific age- and gender-specific low-density lipoprotein cholesterol cutoffs for diagnosis of first-degree relatives with familial hypercholesterolaemia in cascade testing

(2008) Brian Starr et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Reductions in all-cause, cancer, and coronary mortality in statin-treated patients with heterozygous familial hypercholesterolaemia: a prospective registry study

(2008) A. Neil et al.   EUROPEAN HEART JOURNAL

Diagnostic Accuracy of 64-Slice Computed Tomography Coronary Angiography

(2008) W. Bob Meijboom et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Quantitative 3T MR Imaging of the Descending Thoracic Aorta: Patients with Familial Hypercholesterolemia Have an Increased Aortic Plaque Burden Despite Long-Term Lipid-lowering Therapy

(2008) Stephan A. Schmitz et al.   JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY