Article
Biochemistry & Molecular Biology
Vanessa Bianconi, Giacomo Cafaro, Massimo Raffaele Mannarino, Carlo Perricone, Elena Cosentini, Onelia Bistoni, Rita Paltriccia, Rita Lombardini, Roberto Gerli, Matteo Pirro, Elena Bartoloni
Summary: This study found that patients with primary Sjogren's syndrome (pSS) have significantly higher plasma PCSK9 levels compared to healthy controls (HCs), despite having a lower prevalence of dyslipidaemia. However, the relationship between PCSK9 and cardiovascular (CV) risk in pSS patients requires further investigation.
Review
Biochemistry & Molecular Biology
Guzel Bikbova, Toshiyuki Oshitari, Mukharram Bikbov
Summary: There is a clear connection between diabetes and atherosclerotic cardiovascular disease, necessitating therapeutic approaches that target both diseases. Ongoing clinical trials are examining the roles of obesity, adipose tissue, gut microbiota, and pancreatic beta cell function in diabetes. Inflammation plays a crucial role in diabetes pathophysiology and associated metabolic disorders, leading to increased interest in targeting inflammation for diabetes prevention and control. Diabetic retinopathy, a neurodegenerative and vascular disease that develops after poorly controlled diabetes, is also increasingly linked to inflammation. Molecular pathways such as oxidative stress and advanced glycation end-products contribute to the inflammatory response in diabetes-related complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Agnieszka Krupa, Weronika Gonciarz, Paulina Rusek-Wala, Tomasz Rechcinski, Adrian Gajewski, Zuzanna Samsel, Anna Dziuba, Agnieszka Smiech, Magdalena Chmiela
Summary: Chronic Helicobacter pylori infections and a high-fat diet may synergistically contribute to the development of proatherogenic conditions, as evidenced by the infiltration of inflammatory cells into the vascular endothelium and the decreased elasticity of arteries observed in animal models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Max Lenz, Manuel Salzmann, Cosmin Ciotu, Christoph Kaun, Konstantin A. Krychtiuk, Andreja Rehberger Likozar, Miran Sebestjen, Laura Goederle, Sabine Rauscher, Zoriza Krivaja, Christoph J. Binder, Kurt Huber, Christian Hengstenberg, Bruno K. Podesser, Michael J. M. Fischer, Johann Wojta, Philipp J. Hohensinner, Walter S. Speidl
Summary: This study demonstrates the importance of Na+ influx modulation in cellular response to inflammation. Ranolazine, a known antianginal drug, reduces intracellular Na+ levels and shows anti-inflammatory effects in both human patients and a mouse atherosclerotic disease model.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Hematology
Yao Wei Lu, Nina Martino, Brennan D. Gerlach, John M. Lamar, Peter A. Vincent, Alejandro P. Adam, John J. Schwarz
Summary: MEF2 is a critical regulator of vascular homeostasis with downstream effects on gene expression programs involved in atherosclerosis development and the promotion of an anti-inflammatory and antithrombotic endothelium. Its deficiency leads to systemic inflammation, hemorrhage, thrombocytopenia, leukocytosis, and rapid lethality. MEF2 also plays a role in regulating multiple pathways, including the expression of Klf2 and Klf4 for anti-inflammatory and antithrombotic endothelium, as well as Notch family genes for atheroprotection.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Elham Hasheminasabgorji, Jay C. Jha
Summary: Diabetes prevalence is increasing rapidly, leading to various complications and premature mortality. Atherosclerosis, a major macro-vascular complication of diabetes, can be mitigated by controlling dyslipidemia and reducing inflammation and oxidative stress with pharmacological agents.
Review
Biochemistry & Molecular Biology
Helen Williams, Corinne D. Mack, Stephen C. H. Li, John P. Fletcher, Heather J. Medbury
Summary: Monocytes play a crucial role in cardiovascular disease by infiltrating vessel walls to form atherosclerotic plaques. Different subsets of monocytes, including intermediate and nonclassical, have been associated with CVD and changes in inflammatory markers. Dyslipidemia can impact monocyte proportion and function, with lipid lowering medication showing some effect in reversing these changes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Selin Gencer, Yvonne Doering, Yvonne Jansen, Soyolmaa Bayasgalan, Yi Yan, Mariaelvy Bianchini, Ismail Cimen, Madeleine Mueller, Linsey J. F. Peters, Remco T. A. Megens, Philipp von Hundelshausen, Johan Duchene, Patricia Lemnitzer, Oliver Soehnlein, Christian Weber, Emiel P. C. van der Vorst
Summary: Arterial endothelial ACKR3 plays an important role in the development of atherosclerosis by mediating endothelium-immune cell adhesion, most likely through inflammatory MAPK and NF-kB pathways.
BASIC RESEARCH IN CARDIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Ling Xu, Chaoxiang Xu, Xiaoxin Lin, Huiyao Lu, Yinlian Cai
Summary: The study demonstrated that silencing LPAR5 alleviated ox-LDL-induced HUVECs injury by inhibiting NLRP3 inflammasome signaling, leading to improved endothelium function.
Article
Pediatrics
Joanna Sordyl, Ilona Kopyta, Beata Sarecka-Hujar, Pawel Matusik, Tomasz Francuz, Ewa Malecka-Tendera
Summary: No clear clinical changes indicative of atherosclerosis were found in children with primary headaches in this study. However, some trends were observed, with primary headaches more often related to a family history of cardiovascular diseases, and IMT associated with TG levels and BMI z-score.
Review
Biochemistry & Molecular Biology
Panagiotis Theofilis, Marios Sagris, Alexios S. Antonopoulos, Evangelos Oikonomou, Costas Tsioufis, Dimitris Tousoulis
Summary: In the context of dysfunctional vascular endothelium, platelet activation occurs due to structural alterations like endothelial glycocalyx thinning or functional modifications through impaired NO bioavailability. Additionally, neutrophil-derived mediators and neutrophil extracellular traps formation contribute to platelet activation and platelet-leukocyte aggregation. Pro-inflammatory cytokines and their receptors in platelets, along with factors like TNF-alpha, play critical roles in inducing inflammatory responses and affecting platelet activation. Furthermore, new concepts linking inflammation and platelet activation, such as toll-like receptors, myeloperoxidase, and platelet factor-4, have been explored. The evidence is particularly relevant in the context of COVID-19, where excessive inflammation leads to thrombotic complications partially mediated by platelet activation. Advances in anti-inflammatory therapies have shown promise in reducing platelet activation and its thrombotic effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medical Laboratory Technology
Zhe-Bin Cheng, Liang Huang, Xuan Xiao, Jia-Xiang Sun, Zi-Kai Zou, Jie-Feng Jiang, Cong Lu, Hai-Ya Zhang, Chi Zhang
Summary: Irisin is a novel exercise-induced myokine that plays important roles in increasing white adipose tissue browning, regulating energy metabolism, improving insulin resistance, and preventing atherosclerosis. It has the potential to be a therapeutic target and predictive marker for cardiovascular diseases.
CLINICA CHIMICA ACTA
(2021)
Article
Biochemistry & Molecular Biology
Nathan J. Martin, Belal Chami, Abigail Vallejo, Albaraa A. Mojadadi, Paul K. Witting, Gulfam Ahmad
Summary: Intracellular redox imbalance in endothelial cells can lead to cardiovascular diseases, and 4-MetT can ameliorate endothelial dysfunction by inhibiting inflammation induced by SAA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Paul-Mihai Boarescu, Ioana Boarescu, Raluca Maria Pop, Stefan Horia Rosian, Ioana Corina Bocsan, Vasile Rus, Razvan Olimpiu Mada, Iulia Diana Popa, Nicholas Neagu, Adriana Elena Bulboaca, Anca Dana Buzoianu, Sorana D. Bolboaca
Summary: This study aimed to compare the oxidative stress biomarkers, pro-inflammatory cytokines, and histological changes induced by three cardiovascular risk factors. The results showed that hypertension, dyslipidemia, and type 1 diabetes mellitus all increased oxidative stress and inflammation, with type 1 diabetes mellitus having the most significant irreversible changes on the arterial wall.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Min-chun Jiang, Huan-yu Ding, Yu-hong Huang, Chak Kwong Cheng, Chi Wai Lau, Yin Xia, Xiao-qiang Yao, Li Wang, Yu Huang
Summary: Atherosclerotic diseases are a major cause of adult mortality and strain healthcare systems worldwide. A study found that the drug thioridazine can inhibit YAP activity and alleviate endothelial inflammation and atherosclerosis. Thioridazine was shown to have anti-inflammatory effects mediated by inhibiting YAP and regulating RhoA. Furthermore, thioridazine reduced atherosclerosis in two mouse models. This research suggests the potential of repurposing thioridazine for treating atherosclerotic diseases.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Hematology
Roberto Cangemi, Camilla Calvieri, Marco Falcone, Francesco Cipollone, Giancarlo Ceccarelli, Pasquale Pignatelli, Damiano D'Ardes, Matteo Pirro, Francesco Alessandri, Miriam Lichtner, Gabriella D'Ettorre, Alessandra Oliva, Raissa Aronica, Monica Rocco, Mario Venditti, Giulio Francesco Romiti, Giusy Tiseo, Gloria Taliani, Francesco Menichetti, Francesco Pugliese, Claudio Maria Mastroianni, Francesco Violi
Summary: Compared with CAP, COVID-19 is associated with a higher burden of thrombotic events, different types of thrombosis, and a higher risk of thrombosis-related in-hospital mortality.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Peripheral Vascular Disease
Massimo Volpe, Giovanna Gallo, Maria Grazia Modena, Claudio Ferri, Giovambattista Desideri, Giuliano Tocci
Summary: This executive document reflects and updates the key points of a Consensus document on Cardiovascular Prevention. It analyzes and discusses the new recommendations introduced by international guidelines and highlights the importance of effective CV prevention strategies during the COVID-19 outbreak.
HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION
(2022)
Review
Medicine, General & Internal
Amir Vahedian-Azimi, Massimo R. Mannarino, Sajad Shojaie, Farshid Rahimibashar, Hadi Esmaeili Gouvarchin Galeh, Maciej Banach, Vanessa Bianconi, Matteo Pirro, Amirhossein Sahebkar
Summary: The meta-analysis showed that ongoing statin treatment can reduce the prevalence of influenza virus infection and improve survival rates associated with influenza.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Article
Pathology
Vanessa Bianconi, Massimo R. Mannarino, Filippo Figorilli, Elena Cosentini, Giuseppe Batori, Ettore Marini, Maciej Banach, Amirhossein Sahebkar, Matteo Pirro
Summary: This study evaluated the impact of serum ferritin-to-iron ratio (FIR) on the prognosis of hospitalized patients with COVID-19. The findings showed that higher FIR values were associated with more severe symptoms and increased risk of ICU admission/in-hospital death.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2022)
Article
Hematology
Francesco Violi, Pasquale Pignatelli, Anna Rita Vestri, Alessandra Spagnoli, Francesco Cipollone, Giancarlo Ceccarelli, Alessandra Oliva, Maria Amitrano, Matteo Pirro, Gloria Taliani, Roberto Cangemi, Miriam Lichtner, Francesco Pugliese, Marco Falcone, Damiano D'Ardes, Mario Venditti, Claudio Maria Mastroianni, Lorenzo Loffredo
Summary: This study found that a new score (ADA score) combining age, D-dimer, and albumin can be used to predict the risk of thrombosis in patients with SARS-CoV-2. The ADA score can help identify high-risk patients.
THROMBOSIS AND HAEMOSTASIS
(2022)
Review
Geriatrics & Gerontology
Peter E. Penson, Eric Bruckert, David Marais, Zeljko Reiner, Matteo Pirro, Amirhossein Sahebkar, Gani Bajraktari, Erkin Mirrakhimov, Manfredi Rizzo, Dimitri P. Mikhailidis, Alexandros Sachinidis, Dan Gaita, Gustavs Latkovskis, Mohsen Mazidi, Peter P. Toth, Daniel Pella, Fahad Alnouri, Arman Postadzhiyan, Hung- Yeh, G. B. John Mancini, Stephan von Haehling, Maciej Banach
Summary: Statin intolerance is a clinical syndrome that may lead to the discontinuation of therapy and an increased risk of adverse cardiovascular outcomes. Clear guidance is needed to manage perceived adverse effects and improve long-term compliance with lipid-lowering therapy. The International Lipid Expert Panel has proposed a patient-centered approach to address these issues.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Medicine, General & Internal
Sebastiano Cicco, Marco D'Abbondanza, Marco Proietti, Vincenzo Zaccone, Chiara Pes, Federica Caradio, Massimo Mattioli, Salvatore Piano, Alberto Maria Marra, Alessandro Nobili, Pier Mannuccio Mannucci, Antonello Pietrangelo, Giorgio Sesti, Elena Buzzetti, Andrea Salzano, Antonio Cimellaro
Summary: This study investigated the determinants and outcomes of antihypertensive drug prescription in older hospitalized patients. The findings suggest that adherence to guideline-recommended antihypertensive treatment is associated with a lower risk of adverse clinical outcomes.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Medicine, General & Internal
Lorenzo Loffredo, Pasquale Pignatelli, Matteo Pirro, Giancarlo Ceccarelli, Alessandra Oliva, Enrico Maggio, Francesca Cancelli, Damiano D'Ardes, Maria Amitrano, Anna Maria Zicari, Bianca Laura Cinicola, Gloria Taliani, Roberto Cangemi, Miriam Lichtner, Marco Falcone, Federica Orlando, Francesco Pugliese, Mario Venditti, Claudio Maria Mastroianni, Francesco Violi
Summary: The P/F ratio is associated with thrombotic events in COVID-19 patients. A low P/F ratio is associated with thrombocytosis, which may lead to clot formation. This study suggests that the P/F ratio is closely related to thrombotic events in patients with COVID-19.
INTERNAL AND EMERGENCY MEDICINE
(2023)
Article
Medicine, Research & Experimental
Ilais Moreno Velasquez, Anders Malarstig, Damiano Baldassarre, Yan Borne, Ulf de Faire, Gunnar Engstrom, Per Eriksson, Philippe Giral, Steve E. Humphries, Sudhir Kurl, Karin Leander, Lars Lind, Anders Linden, Nicola Orsini, Matteo Pirro, Angela Silveira, Andries J. Smit, Elena Tremoli, Fabrizio Veglia, Rona J. Strawbridge, Bruna Gigante
Summary: The study found a causal relationship between plasma IL-8 and carotid intima-media thickness (c-IMT), a measure of sub-clinical atherosclerosis. The association was confirmed through quantile regression analysis in the multicenter European study IMPROVE, and genetic variants were identified to be associated with both IL-8 levels and c-IMT measures. Replication and meta-analysis further supported the effect of IL-8 on c-IMT.
CURRENT RESEARCH IN TRANSLATIONAL MEDICINE
(2023)
Article
Virology
Vanessa Bianconi, Massimo R. Mannarino, Elena Cosentini, Filippo Figorilli, Cecilia Colangelo, Giulia Cellini, Marco Braca, Rita Lombardini, Rita Paltriccia, Amirhossein Sahebkar, Matteo Pirro
Summary: This study found that preadmission statin therapy is associated with a reduced risk of intensive care unit admission or in-hospital death among patients with COVID-19 at high CV risk. Furthermore, statin therapy is associated with improved endothelial function. However, the interaction between endothelial function and statin therapy is not associated with in-hospital outcomes.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Pharmacology & Pharmacy
Manfredi Rizzo, Alessandro Colletti, Peter E. Penson, Niki Katsiki, Dimitri P. Mikhailidis, Peter P. Toth, Ioanna Gouni-Berthold, John Mancini, David Marais, Patrick Moriarty, Massimiliano Ruscica, Amirhossein Sahebkar, Dragos Vinereanu, Arrigo Francesco Giuseppe Cicero, Maciej Banach
Summary: Non-Alcoholic Fatty Liver Disease (NAFLD) is a common condition with a high prevalence in adults, children, and individuals with type 2 diabetes mellitus. It is a leading cause of liver-related morbidity and cardiovascular mortality. The use of nutraceuticals in managing NAFLD has been suggested, but there is currently insufficient evidence to support their routine use. Further rigorous trials are needed to evaluate their efficacy and safety.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Chemistry, Medicinal
Sahar Dadkhah Tehrani, Mehrnaz Shojaei, Mohammad Bagherniya, Matteo Pirro, Amirhossein Sahebkar
Summary: This systematic review aimed to evaluate the efficacy of phytochemicals on lipid parameters in patients with hypertriglyceridemia (HTG). Forty-eight RCTs including 53 arms and comprising 3,478 HTG patients met the eligibility criteria. Phytochemicals significantly reduced the serum levels of triglycerides, total cholesterol, low-density lipoprotein cholesterol, and apolipoprotein B, while increasing high-density lipoprotein cholesterol levels in HTG patients.
PHYTOTHERAPY RESEARCH
(2023)
Review
Cardiac & Cardiovascular Systems
Maciej Banach, Peter E. Penson, Michel Farnier, Zlatko Fras, Gustavs Latkovskis, Ulrich Laufs, Francesco Paneni, Paolo Parini, Matteo Pirro, Zeljko Reiner, Michal Vrablik, Carlos Escobar
Summary: Cardiovascular disease (CVD) is a chronic non-communicable disease and the leading cause of disability and mortality worldwide. The current lipid-lowering treatments need improvement, and bempedoic acid, as a new approach to reduce lipid levels, has the potential to lower the risk of CVD.
PROGRESS IN CARDIOVASCULAR DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Buamina Maitusong, Federica J. Laguzzi, Rona Strawbridge, Damiano Baldassarre, Fabrizio E. Veglia, Steve Humphries, Kai Savonen, Sudhir Kurl, Matteo J. Pirro, Andries Smit, Philippe Giral, Angela Silveira, Elena Tremoli, Anders Hamsten, Ulf de Faire, Bruna Gigante, Karin Leander, IMPROVE Study Grp
Summary: The study found that certain genetic variants may modify the effect of smoking on carotid intima-media thickness, increasing the risk of atherosclerosis.
CIRCULATION-GENOMIC AND PRECISION MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Filippo Figorilli, Massimo Raffaele Mannarino, Amirhossein Sahebkar, Matteo Pirro
Summary: Introduction: Atherosclerotic cardiovascular disease (ASCVD) is the main cause of morbidity and mortality worldwide. Dyslipidemia, especially elevation of LDL-cholesterol levels (LDL-C), is a major cardiovascular risk factor, but often goes undiagnosed due to its asymptomatic course. Strategies aimed at early identification of individuals with elevated LDL-C levels may allow for early intervention to prevent ASCVD development.
EXPERT REVIEW OF CARDIOVASCULAR THERAPY
(2023)