GluN2D NMDA Receptors Gate Fear Extinction Learning and Interneuron Plasticity

BNST GluN2D-Containing NMDA Receptors Influence Anxiety- and Depressive-like Behaviors and ModulateCell-Specific Excitatory/Inhibitory Synaptic Balance

(2020) Gregory J. Salimando et al.   JOURNAL OF NEUROSCIENCE

Bidirectional control of fear memories by cerebellar neurons projecting to the ventrolateral periaqueductal grey

(2020) Jimena Laura Frontera et al.   Nature Communications

Inhibitory neurotransmission drives endocannabinoid degradation to promote memory consolidation

(2020) Christophe J. Dubois et al.   Nature Communications

Neurochemical and molecular mechanisms underlying the retrieval-extinction effect

(2019) Emma N. Cahill et al.   PSYCHOPHARMACOLOGY

The glycine site of NMDA receptors: A target for cognitive enhancement in psychiatric disorders

(2019) Bahareh Peyrovian et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Differential effect of NMDA receptor GluN2C and GluN2D subunit ablation on behavior and channel blocker-induced schizophrenia phenotypes

(2019) Gajanan P. Shelkar et al.   Scientific Reports

The cerebellum is involved in processing of predictions and prediction errors in a fear conditioning paradigm

(2019) Thomas Michael Ernst et al.   eLife

In the Telencephalon, GluN2C NMDA Receptor Subunit mRNA is Predominately Expressed in Glial Cells and GluN2D mRNA in Interneurons

(2018) Hassan A. Alsaad et al.   NEUROCHEMICAL RESEARCH

Rodent models of impaired fear extinction

(2018) Nicolas Singewald et al.   PSYCHOPHARMACOLOGY

Role of NMDA receptor GluN2D subunit in the antidepressant effects of enantiomers of ketamine

(2017) Soichiro Ide et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Identification of AICP as a GluN2C-Selective N -Methyl-d-Aspartate Receptor Superagonist at the GluN1 Glycine Site

(2017) Maja Jessen et al.   MOLECULAR PHARMACOLOGY

Synaptic Plasticity, Engrams, and Network Oscillations in Amygdala Circuits for Storage and Retrieval of Emotional Memories

(2017) Marco Bocchio et al.   NEURON

Loss of GluN2D subunit results in social recognition deficit, social stress, 5-HT2C receptor dysfunction, and anhedonia in mice

(2017) Hideko Yamamoto et al.   NEUROPHARMACOLOGY

Activation of Nigrostriatal Dopamine Neurons during Fear Extinction Prevents the Renewal of Fear

(2017) Courtney A Bouchet et al.   NEUROPSYCHOPHARMACOLOGY

Enhancement of Psychosocial Treatment With D-Cycloserine: Models, Moderators, and Future Directions

(2016) Michael W. Otto et al.   BIOLOGICAL PSYCHIATRY

The key role of extinction learning in anxiety disorders

(2016) Andre Pittig et al.   CURRENT OPINION IN PSYCHIATRY

Presynaptic GluN2D receptors detect glutamate spillover and regulate cerebellar GABA release

(2016) Christophe J. Dubois et al.   JOURNAL OF NEUROPHYSIOLOGY

Fear Memory

(2016) Ivan Izquierdo et al.   PHYSIOLOGICAL REVIEWS

Extinction and Retrieval + Extinction of Conditioned Fear Differentially Activate Medial Prefrontal Cortex and Amygdala in Rats

(2016) Hongjoo J. Lee et al.   Frontiers in Behavioral Neuroscience

An Overview of Translationally Informed Treatments for Posttraumatic Stress Disorder: Animal Models of Pavlovian Fear Conditioning to Human Clinical Trials

(2015) Mallory E. Bowers et al.   BIOLOGICAL PSYCHIATRY

Mechanisms regulating spill-over of synaptic glutamate to extrasynaptic NMDA receptors in mouse substantia nigra dopaminergic neurons

(2015) A. R. Wild et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Neuronal circuits for fear and anxiety

(2015) Philip Tovote et al.   NATURE REVIEWS NEUROSCIENCE

Neuronal circuits for fear and anxiety — the missing link

(2015) Richard Apps et al.   NATURE REVIEWS NEUROSCIENCE

Rethinking Extinction

(2015) Joseph E. Dunsmoor et al.   NEURON

The anatomy of fear learning in the cerebellum: A systematic meta-analysis

(2015) Iris Lange et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Cerebellar vermis contributes to the extinction of conditioned fear

(2015) A. Utz et al.   NEUROSCIENCE LETTERS

GluN2D-containing NMDA receptors-mediate synaptic currents in hippocampal interneurons and pyramidal cells in juvenile mice

(2015) Jakob von Engelhardt et al.   Frontiers in Cellular Neuroscience

Opposing Role of NMDA Receptor GluN2B and GluN2D in Somatosensory Development and Maturation

(2014) M. Yamasaki et al.   JOURNAL OF NEUROSCIENCE

Mg2+block properties of triheteromeric GluN1-GluN2B-GluN2D NMDA receptors on neonatal rat substantia nigra pars compacta dopaminergic neurones

(2014) Zhuo Huang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Extinction, applied after retrieval of auditory fear memory, selectively increases zinc-finger protein 268 and phosphorylated ribosomal protein S6 expression in prefrontal cortex and lateral amygdala

(2014) Vincenzo Tedesco et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Cerebellar Contributions to Different Phases of Visceral Aversive Extinction Learning

(2013) Joswin Kattoor et al.   CEREBELLUM

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

(2013) Pierre Paoletti et al.   NATURE REVIEWS NEUROSCIENCE

Potentiation of GluN2C/D NMDA Receptor Subtypes in the Amygdala Facilitates the Retention of Fear and Extinction Learning in Mice

(2013) Kevin K Ogden et al.   NEUROPSYCHOPHARMACOLOGY

Emerging roles of metaplasticity in behaviour and disease

(2013) Sarah R. Hulme et al.   TRENDS IN NEUROSCIENCES

Involvement of the N-methyl-d-aspartate receptor GluN2D subunit in phencyclidine-induced motor impairment, gene expression, and increased Fos immunoreactivity

(2013) Hideko Yamamoto et al.   Molecular Brain

Sex-Dependent Behavioral Functions of the Purkinje Cell-Specific Gαi/o Binding Protein, Pcp2(L7)

(2012) James C. Walton et al.   CEREBELLUM

Synaptic plasticity of NMDA receptors: mechanisms and functional implications

(2012) David L Hunt et al.   CURRENT OPINION IN NEUROBIOLOGY

Unconditioned responses and functional fear networks in human classical conditioning

(2011) Clas Linnman et al.   BEHAVIOURAL BRAIN RESEARCH

Behavioral analysis of NR2C knockout mouse reveals deficit in acquisition of conditioned fear and working memory

(2011) Brandon G. Hillman et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

NMDA GluN2A and GluN2B receptors play separate roles in the induction of LTP and LTD in the amygdala and in the acquisition and extinction of conditioned fear

(2011) Gemma L. Dalton et al.   NEUROPHARMACOLOGY

Effect of d-cycloserine and valproic acid on the extinction of reinstated fear-conditioned responses and habituation of fear conditioning in healthy humans: a randomized controlled trial

(2011) Kenichi Kuriyama et al.   PSYCHOPHARMACOLOGY

Structural Determinants of D-Cycloserine Efficacy at the NR1/NR2C NMDA Receptors

(2010) S. M. Dravid et al.   JOURNAL OF NEUROSCIENCE

Calcium-Permeable AMPA Receptor Dynamics Mediate Fear Memory Erasure

(2010) R. L. Clem et al.   SCIENCE

The human cerebellum contributes to motor, emotional and cognitive associative learning. A review

(2009) D. Timmann et al.   CORTEX

Glutamatergic Modulation of Cerebellar Interneuron Activity Is Mediated by an Enhancement of GABA Release and Requires Protein Kinase A/RIM1  Signaling

(2009) P. M. Lachamp et al.   JOURNAL OF NEUROSCIENCE

A single fear-inducing stimulus induces a transcription-dependent switch in synaptic AMPAR phenotype

(2009) Yu Liu et al.   NATURE NEUROSCIENCE

Extinction-Reconsolidation Boundaries: Key to Persistent Attenuation of Fear Memories

(2009) M.-H. Monfils et al.   SCIENCE

Learning-related long-term potentiation of inhibitory synapses in the cerebellar cortex

(2008) B. Scelfo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NR2B- and NR2D-containing synaptic NMDA receptors in developing rat substantia nigra pars compacta dopaminergic neurones

(2007) S. L. C. Brothwell et al.   JOURNAL OF PHYSIOLOGY-LONDON