Rutin Mediated Apoptotic Cell Death in Caski Cervical Cancer Cells via Notch-1 and Hes-1 Downregulation

Elucidation of rutin’s role in inducing caspase-dependent apoptosis via HPV-E6 and E7 down-regulation in cervical cancer HeLa cells

(2021) Pratibha Pandey et al.   BIOSCIENCE REPORTS

Role of Rutin Nanoemulsion in Ameliorating Oxidative Stress: Pharmacokinetic and Pharmacodynamics Studies

(2020) Shrestha Sharma et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Molecular and Immunological Mechanisms Underlying the Various Pharmacological Properties of the Potent Bioflavonoid, Rutin

(2020) David Ong Cherk Yong et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Moringa oleifera methanolic leaves extract induces apoptosis and G0/G1 cell cycle arrest via downregulation of Hedgehog Signaling Pathway in human prostate PC‐3 cancer cells

(2020) Fahad Khan et al.   JOURNAL OF FOOD BIOCHEMISTRY

Rutin ameliorates copper sulfate‐induced brain damage via antioxidative and anti‐inflammatory activities in rats

(2020) Jeremiah Arowoogun et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Jab1 Inhibition by Methanolic Extract of Moringa Oleifera Leaves in Cervical Cancer Cells: A Potent Targeted Therapeutic Approach

(2020) Pratibha Pandey et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Targeting Multiple Signaling Pathways in Cancer: The Rutin Therapeutic Approach

(2020) Zeinab Nouri et al.   Cancers

Targeting Notch in oncology: the path forward

(2020) Samarpan Majumder et al.   NATURE REVIEWS DRUG DISCOVERY

Therapeutic potential of hesperidin and its aglycone hesperetin: cell cycle regulation and apoptosis induction in cancer models

(2019) José Miguel P. Ferreira de Oliveira et al.   PHYTOMEDICINE

Notch pathway in ependymoma RELA-fused subgroup: upregulation and association with cancer stem cells markers expression

(2019) Taciani de Almeida Magalhães et al.   CANCER GENE THERAPY

Anticancerous effect of rutin against HPV- C33A cervical cancer cells via G0/G1 cell cycle arrest and apoptotic induction

(2019) Fahad Khan et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Carvacrol Induced Program Cell Death and Cell Cycle Arrest in Androgen-Independent Human Prostate Cancer Cells via Inhibition of Notch Signaling

(2019) Fahad Khan et al.   Anti-Cancer Agents in Medicinal Chemistry

Notch signalling in cervical cancer

(2019) Calvin Rodrigues et al.   EXPERIMENTAL CELL RESEARCH

Global burden of cancer attributable to infections in 2018: a worldwide incidence analysis

(2019) Catherine de Martel et al.   Lancet Global Health

Glycyrrhizin induces reactive oxygen species-dependent apoptosis and cell cycle arrest at G 0 /G 1 in HPV18 + human cervical cancer HeLa cell line

(2018) Arshi Farooqui et al.   BIOMEDICINE & PHARMACOTHERAPY

Eurogin roadmap 2017: Triage strategies for the management of HPV-positive women in cervical screening programs

(2018) Kate Cuschieri et al.   INTERNATIONAL JOURNAL OF CANCER

Kaempferol suppresses proliferation and induces cell cycle arrest, apoptosis, and DNA damage in breast cancer cells

(2018) Li Zhu et al.   ONCOLOGY RESEARCH

Bioactive flavonoids in medicinal plants: Structure, activity and biological fate

(2018) Tian-yang Wang et al.   Asian Journal of Pharmaceutical Sciences

FLI-06 suppresses proliferation, induces apoptosis and cell cycle arrest by targeting LSD1 and Notch pathway in esophageal squamous cell carcinoma cells

(2018) Zhaoming Lu et al.   BIOMEDICINE & PHARMACOTHERAPY

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Health impact of delayed implementation of cervical cancer screening programs in India: A modelling analysis

(2018) Nicole G. Campos et al.   INTERNATIONAL JOURNAL OF CANCER

Flavonoids inhibit cell proliferation and induce apoptosis and autophagy through downregulation of PI3Kγ mediated PI3K/AKT/mTOR/p70S6K/ULK signaling pathway in human breast cancer cells

(2018) Hong-Wei Zhang et al.   Scientific Reports

A novel rutin-fucoidan complex based phytotherapy for cervical cancer through achieving enhanced bioavailability and cancer cell apoptosis

(2018) Murugesan Sathiya Deepika et al.   BIOMEDICINE & PHARMACOTHERAPY

Flavonoids: biological activities and therapeutic potential

(2018) Mércia Marques Jucá et al.   NATURAL PRODUCT RESEARCH

Rutin and orlistat produce antitumor effects via antioxidant and apoptotic actions

(2018) Amira Saleh et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Dietary supplementation with rutin has pro-/anti-inflammatory effects in the liver of juvenile GIFT tilapia, Oreochromis niloticus

(2017) Yao Zheng et al.   FISH & SHELLFISH IMMUNOLOGY

Molecular and immunohistochemical expression of apoptotic proteins Bax, Bcl-2 and Caspase 3 in infantile hemangioma tissues as an effect of propranolol treatment

(2017) Aneta Wnęk et al.   IMMUNOLOGY LETTERS

Molecular Mechanisms and Pathways as Targets for Cancer Prevention and Progression with Dietary Compounds

(2017) Nagisa Nosrati et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Understanding the Effectiveness of Natural Compound Mixtures in Cancer through Their Molecular Mode of Action

(2017) Thazin Aung et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bax/Bak-independent mitochondrial depolarization and reactive oxygen species induction by sorafenib overcome resistance to apoptosis in renal cell carcinoma

(2017) Bernhard Gillissen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Natural compounds targeting major cell signaling pathways: a novel paradigm for osteosarcoma therapy

(2017) Pablo Angulo et al.   Journal of Hematology & Oncology

Inhibiting CDK in Cancer Therapy: Current Evidence and Future Directions

(2017) Smruthi Vijayaraghavan et al.   Targeted Oncology

Rutin: A review on extraction, identification and purification methods, biological activities and approaches to enhance its bioavailability

(2017) Beatriz Gullón et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

The Pharmacological Potential of Rutin

(2017) Aditya Ganeshpurkar et al.   SAUDI PHARMACEUTICAL JOURNAL

Bisphenol A induces cell cycle arrest in primary and prostate cancer cells through EGFR/ERK/p53 signaling pathway activation

(2017) Antonio Bilancio et al.   Oncotarget

Mitochondria and Mitochondrial ROS in Cancer: Novel Targets for Anticancer Therapy

(2016) Yuhui Yang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cell death mechanisms of plant-derived anticancer drugs: beyond apoptosis

(2015) Hala Gali-Muhtasib et al.   APOPTOSIS

MiR-139-5p inhibits the biological function of breast cancer cells by targeting Notch1 and mediates chemosensitivity to docetaxel

(2015) He-da Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting Apoptosis and Multiple Signaling Pathways with Icariside II in Cancer Cells

(2015) Muhammad Khan et al.   International Journal of Biological Sciences

Clinical Impact of De-Regulated Notch-1 and Notch-3 in the Development and Progression of HPV-Associated Different Histological Subtypes of Precancerous and Cancerous Lesions of Human Uterine Cervix

(2014) Richa Tripathi et al.   PLoS One

Notch-driven carcinogenesis: The merging of hepatocellular cancer and cholangiocarcinoma into a common molecular liver cancer subtype

(2013) Nataliya Razumilava et al.   JOURNAL OF HEPATOLOGY

Targeting Cell Signaling and Apoptotic Pathways by Dietary Agents: Role in the Prevention and Treatment of Cancer

(2011) Muthu Shanmugam et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Grape Proanthocyanidins Induce Apoptosis by Loss of Mitochondrial Membrane Potential of Human Non-Small Cell Lung Cancer Cells In Vitro and In Vivo

(2011) Tripti Singh et al.   PLoS One

Combined Inhibition of Notch Signaling and Bcl-2/Bcl-xL Results in Synergistic Antimyeloma Effect

(2010) M. Li et al.   MOLECULAR CANCER THERAPEUTICS

Plant-derived compounds in clinical trials

(2007) A SAKLANI et al.   DRUG DISCOVERY TODAY