One-Pot Three-Component Synthesis of 2-Methyl-3-aminobenzofurans Using Calcium Carbide as a Concise Solid Alkyne Source

Main observation and conclusion A one-pot three-component method for the synthesis of 2-methyl-3-aminobenzofurans using calcium carbide as a concise solid alkyne source, and salicylaldehydes and secondary amines as starting materials is described. This protocol has salient feature of the use of inexpensive, abundant and easy-to-handle alkyne source, avoiding the use of inflammable and explosive acetylene gas as an original alkyne source. In addition, step economy, satisfactory yield, and simple work-up procedure are also advantages of this route.

Automated summary

The method utilizes calcium carbide as a solid alkyne source to efficiently synthesize 2-methyl-3-aminobenzofurans, avoiding the use of flammable and explosive acetylene gas. It offers the advantages of being cost-effective, abundant, and easy to handle.