Journal
COMMUNICATIONS BIOLOGY
Volume 4, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s42003-021-02447-w
Keywords
-
Categories
Funding
- Austrian Science Fund (FWF), PhD Programme Imaging the Mind: Connectivity and Higher Cognitive Function [W 1233-G17]
- Single Investigator Project [P28261]
- European Research Council (ERC) [850953]
- Australian Research Council [DE170100128, DP200100757]
- Australian Research Council [DE170100128, DP200100757] Funding Source: Australian Research Council
- European Research Council (ERC) [850953] Funding Source: European Research Council (ERC)
Ask authors/readers for more resources
Hidalgo-Lopez et al. utilized spectral dynamic causal modelling to investigate changes in effective connectivity related to menstrual phase and hormonal levels in healthy women. Their findings provide additional insights into how the brain responds to hormone fluctuations throughout the menstrual cycle.
Longitudinal menstrual cycle studies allow to investigate the effects of ovarian hormones on brain organization. Here, we use spectral dynamic causal modelling (spDCM) in a triple network model to assess effective connectivity changes along the menstrual cycle within and between the default mode, salience and executive control networks (DMN, SN, and ECN). Sixty healthy young women were scanned three times along their menstrual cycle, during early follicular, pre-ovulatory and mid-luteal phase. Related to estradiol, right before ovulation the left insula recruits the ECN, while the right middle frontal gyrus decreases its connectivity to the precuneus and the DMN decouples into anterior/posterior parts. Related to progesterone during the mid-luteal phase, the insulae (SN) engage to each other, while decreasing their connectivity to parietal ECN, which in turn engages the posterior DMN. When including the most confident connections in a leave-one out cross-validation, we find an above-chance prediction of the left-out subjects' cycle phase. These findings corroborate the plasticity of the female brain in response to acute hormone fluctuations and may help to further understand the neuroendocrine interactions underlying cognitive changes along the menstrual cycle. Hidalgo-Lopez et al. use dynamic causal modelling to investigate changes in effective connectivity related to menstrual phase and hormonal levels in healthy women. Their results provide further insight into how the brain responds to hormone fluctuations throughout the menstrual cycle.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available