Journal
COMMUNICATIONS BIOLOGY
Volume 4, Issue 1, Pages -Publisher
NATURE RESEARCH
DOI: 10.1038/s42003-021-02149-3
Keywords
-
Categories
Funding
- Research Committee of the Medical Faculty of the Heinrich Heine University Dusseldorf [2020-70/9772617]
- German Research Foundation (Deutsche Forschungsgemeinschaft or DFG) [AH 92/8-1]
- European Network on Noonan Syndrome and Related Disorders (NSEuroNet) [01GM1621B]
- German Federal Ministry of Education and Research (BMBF)-German Network of RASopathy Research (GeNeRARe) [01GM1902C]
- German Research Foundation (Deutsche Forschungsgemeinschaft or DFG) through the International Research Training Group 'Intra- and interorgan communication of the cardiovascular system' [IRTG 1902-p6]
Ask authors/readers for more resources
Health and disease are directly related to the RTK-RAS-MAPK signalling cascade, but understanding its spatiotemporal features is afflicted with major conceptual shortcomings. Compiling a vast array of accessory proteins could help resolve some puzzles in this field.
Health and disease are directly related to the RTK-RAS-MAPK signalling cascade. After more than three decades of intensive research, understanding its spatiotemporal features is afflicted with major conceptual shortcomings. Here we consider how the compilation of a vast array of accessory proteins may resolve some parts of the puzzles in this field, as they safeguard the strength, efficiency and specificity of signal transduction. Targeting such modulators, rather than the constituent components of the RTK-RAS-MAPK signalling cascade may attenuate rather than inhibit disease-relevant signalling pathways.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
